RESUMEN
The emission of high-power broad-area semiconductor lasers inherently contains many lateral modes that increase the beam divergence and reduce the spatial coherence. Elimination of higher-order lateral modes from the output beams of commercially available broad-area lasers will be beneficial in many applications of these lasers. Experimental results obtained with a broad-area laser coupled to an anamorphic external cavity are presented and are compared with the predictions from our numerical model. We have predicted and observed with the anamorphic external cavity a greatly improved discrimination against high-order lateral modes. The measurement of the spectrally resolved near-field intensity patterns provides much more comprehensive information on their longitudinal- and lateral-mode content than do observations of near-field and far-field beam intensity profiles. With a broad-area laser of 100-mW nominal power, it has been possible to extract 40% of the maximal power in a stable single-lateral and single-longitudinal mode regime.
RESUMEN
The transmembrane serine aminopeptidase dipeptidyl peptidase IV (DPP IV) (also known as CD26) participates in several immunological functions and has a binding affinity for several molecules, including collagen, which may be an integral mechanism for T cells to traverse endothelial barriers. Since CD26 is phenotypically expressed in certain T-cell malignancies, this study utilized a novel four-color cytofluorographic procedure to measure DPP IV enzymatic activity concurrently with the expression of other surface markers in an aggressive hepatosplenic T-cell lymphoma. Immunophenotypic analysis by flow cytometry revealed the tumor to be CD2+, CD3+, CD5-, CD7+, TcR-gamma/delta+, CD4-, CD8+/-, CD56+, and CD11c+. The CD26 molecule was also expressed, and DPP IV activity was present, with the maximal activity detectable after 10 min of incubation. These results represent the initial description of enzymatically active CD26 in a T-cell malignancy, and raise the possibility that this molecule may be a participant in the pathogenetic mechanisms utilized by the neoplastic cells.
Asunto(s)
Dipeptidil Peptidasa 4/metabolismo , Neoplasias Hepáticas/metabolismo , Linfoma de Células T/metabolismo , Neoplasias del Bazo/metabolismo , Adolescente , Médula Ósea/patología , Resultado Fatal , Citometría de Flujo , Humanos , Neoplasias Hepáticas/patología , Linfoma de Células T/patología , Masculino , Neoplasias del Bazo/patologíaRESUMEN
Phase-conjugate reflectivity obtained by degenerate four-wave mixing are measured in different azo dye solutions. A reflectivity up to 80% was achieved. Values of the nonlinear susceptibility chi((3)) are calculated, and its origin is discussed.
RESUMEN
A pharmacokinetic study of 13-cis-retinoic acid was performed in nine patients following administration of a single oral dose of 80 mg. An average lag time of 1.2 hours was observed, followed by fast absorption, with a mean half-life of 0.5 hour. Peak plasmatic concentration of 733 ng/ml occurred at 2.3 hours. The disposition profile showed a rapid distribution half-life of 1.3 hours and a terminal elimination half-life of 24.7 hours. No 13-cis-retinoic acid was detected unchanged in urine. An important interpatient variability was noted.