RESUMEN

An adult patient had a syndrome associating the features of juvenile dermatomyositis and cutaneous polyarteritis nodosa that followed a cyclic course from childhood; recurrences were always associated with a rise of serum antistreptococcal antibodies. Regions of homology between streptococcal type 5 M protein and skeletal myosin were found. These findings suggest that streptococcal infection, possibly through a molecular mimicry mechanism, played a role in the pathogenesis of the disease in our patient.

Asunto(s)

Antígenos Bacterianos , Proteínas de la Membrana Bacteriana Externa , Proteínas Bacterianas/química , Proteínas Portadoras , Dermatomiositis/complicaciones , Miosinas/química , Poliarteritis Nudosa/complicaciones , Enfermedades Cutáneas Vasculares/complicaciones , Enfermedad Aguda , Adulto , Antiestreptolisina/análisis , Dermatomiositis/inmunología , Dermatomiositis/metabolismo , Dermatomiositis/microbiología , Humanos , Masculino , Necrosis , Poliarteritis Nudosa/inmunología , Poliarteritis Nudosa/metabolismo , Poliarteritis Nudosa/microbiología , Recurrencia , Homología de Secuencia de Aminoácido , Enfermedades Cutáneas Vasculares/inmunología , Enfermedades Cutáneas Vasculares/metabolismo , Enfermedades Cutáneas Vasculares/microbiología