RESUMEN
OBJECTIVE: The objective of this clinical study was to evaluate and compare the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride (from sodium fluoride) in a silica base (test dentifrice) to a control dentifrice containing 1450 ppm fluoride (from sodium fluoride) in a silica base, to reduce dentin hypersensitivity immediately after a single dab-on self-application, and after subsequent twice-daily brushing for three days. METHODS: This was a randomized, examiner-blind, two-arm parallel group, three-day clinical study with seventy-nine subjects, stratified based on baseline tooth sensitivity. Tooth sensitivity was determined through subject responses to both evaporative (Schiff and Visual Analogue Scale [VAS]) and tactile stimuli (Yeaple probe), prior to and immediately after subjects self-applied a single pea-sized amount of either the test or control dentifrice to qualifying sensitive teeth, massaging the toothpaste onto the sensitive area for one minute. Tooth sensitivity was further assessed in response to the same stimuli after subjects brushed twice daily for an additional three days. Subject assessments were performed by the same examiner throughout the study. RESULTS: Seventy-nine subjects completed this clinical study. Both subject groups exhibited reductions in dentin hypersensitivity directly after a single dab-on application. These reductions were significant across all measures for the test dentifrice. Between-treatment analyses showed the test dentifrice to be significantly better at relieving subjects' sensitivity across all measures (Schiff p = 0.0003, tactile p = 0.0003, and VAS p = 0.0077) compared to the control. After the additional three days of twice-daily brushing, between-treatment analyses showed the test dentifrice to be significantly better at relieving subjects' sensitivity across all measures (Schiff p = 0.0102, tactile p = 0.0493, and VAS p = 0.0067) than the control dentifrice. CONCLUSION: The 8% strontium acetate, 1040 ppm fluoride dentifrice provided significant within-treatment reductions in dentin hypersensitivity for all measures at both time points (immediate and three-day brushing). Compared to the control dentifrice, significant between-treatment reductions in sensitivity were observed after a single dab-on application for all measures, and following the additional twice-daily brushing for three days in favor of the 8% strontium acetate, 1040 ppm fluoride dentifrice.
Asunto(s)
Acetatos/uso terapéutico , Dentífricos/uso terapéutico , Desensibilizantes Dentinarios/uso terapéutico , Sensibilidad de la Dentina/tratamiento farmacológico , Fluoruros/uso terapéutico , Estroncio/uso terapéutico , Administración Tópica , Adulto , Aire , Sensibilidad de la Dentina/clasificación , Método Doble Ciego , Femenino , Fluoruros/administración & dosificación , Estudios de Seguimiento , Humanos , Masculino , Estimulación Física , Dióxido de Silicio , Fluoruro de Sodio/administración & dosificación , Fluoruro de Sodio/uso terapéutico , Cepillado Dental/instrumentación , Tacto , Resultado del TratamientoRESUMEN
OBJECTIVES: To compare the effectiveness of dentifrice/mouthrinse regimens in a clinical in situ erosion remineralisation model. METHODS: Thirty-six subjects completed a randomised single-blind cross-over trial of five treatment regimens. R1: Dentifrice A [1450 ppm fluoride as the sodium salt (NaF), 50000 ppm potassium nitrate (KNO(3))] plus 450 ppm fluoride (NaF) rinse; R2: Dentifrice A plus sterile water rinse; R3: Dentifrice B (fluoride-free Dentifrice A) plus sterile water rinse; R4: Dentifrice B plus 450 ppm fluoride (NaF) rinse; R5: Dentifrice C (1000 ppm fluorine as sodium monofluorophosphate, 450 ppm fluoride as NaF) plus sterile water rinse. Subjects wore a palatal appliance holding eight pre-demineralised enamel blocks. A 60 min interval separated in vivo use of dentifrice and rinse with the appliance retained in situ for 4h. Efficacy endpoints were percentage surface microhardness recovery (%SMHR) following remineralisation, and percentage relative erosion resistance (%RER) of recovered specimens following a subsequent in vitro erosive challenge. Statistical analyses included ANOVA and selected twin-tailed t-tests. RESULTS: Mean %SMHR (±SE) was (a)42.14±1.39, (b)38.02±1.39, (c)30.57±1.39, (b)37.75±1.39 and (c)30.88±1.39 for regimens R1-R5 respectively (different superscripts denote statistically significant differences (p<0.05) between treatment regimens). Mean %RER (±SE) was (a)-2.88±2.16, (b)-14.54±2.16, (c)-40.05±2.16, (a)-3.76±2.16 and (d)-29.48±2.16 for regimens R1-R5 respectively. R1 elicited statistically significantly greater %SMHR versus all comparator regimens (p<0.01), and conferred statistically significantly greater %RER than comparator regimens (p<0.0001) except R4 (p=0.70). CONCLUSIONS: The combination treatment of dentifrice A containing 1450 ppm fluoride with the 450 ppm fluoride mouthrinse elicited significant enhancements in rehardening of incipient enamel erosive lesions, and significantly increased their subsequent resistance to a second erosive challenge.
Asunto(s)
Esmalte Dental/efectos de los fármacos , Dentífricos/uso terapéutico , Fluoruros Tópicos/administración & dosificación , Antisépticos Bucales/uso terapéutico , Erosión de los Dientes/prevención & control , Remineralización Dental/métodos , Adulto , Anciano , Análisis de Varianza , Terapia Combinada , Estudios Cruzados , Esmalte Dental/ultraestructura , Dentífricos/química , Sensibilidad de la Dentina/prevención & control , Combinación de Medicamentos , Sistemas de Liberación de Medicamentos/métodos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Antisépticos Bucales/química , Nitratos/administración & dosificación , Compuestos de Potasio/administración & dosificación , Valores de Referencia , Método Simple Ciego , Estadísticas no Paramétricas , Propiedades de Superficie , Adulto JovenRESUMEN
OBJECTIVE: To assess the extrinsic stain removal efficacy of a new sensitivity dentifrice containing sodium tripolyphosphate (STP) to marketed whitening toothpastes after six weeks of product use. METHODS: This was a single-center, double-blind, stratified, six-week clinical study comparing the reduction in stain area and intensity of Sensodyne Extra Whitening to Crest Maximum Strength Sensitivity Protection Whitening plus Scope and Colgate Tartar Control Plus Whitening Mint dentifrice, as measured by MacPherson's Modification of the Lobene Stain Index (MMLSI) in a forced stain model. RESULTS: Two-hundred and ninety-five subjects completed the study. Tooth stain MMSLI scores showed significant differences between Sensodyne and Crest dentifrices in favor of Sensodyne for all surface sites (p = 0.014), and individually for facial (p = 0.023), lingual (p = 0.027), and interproximal (p = 0.014) surfaces. No significant statistical differences between Sensodyne and Colgate dentifrices were observed for any of the surfaces. CONCLUSION: Results from this stain removal clinical study demonstrate significant extrinsic stain removal efficacy for all dentifrices relative to baseline. Significant differences between the two marketed sensitivity whitening dentifrices were demonstrated in favor of the new Sensodyne Sensitivity Whitening dentifrice.
Asunto(s)
Dentífricos/uso terapéutico , Decoloración de Dientes/tratamiento farmacológico , Adulto , Dentífricos/química , Desensibilizantes Dentinarios/uso terapéutico , Sensibilidad de la Dentina/complicaciones , Sensibilidad de la Dentina/tratamiento farmacológico , Método Doble Ciego , Femenino , Humanos , Masculino , Persona de Mediana Edad , Polifosfatos/uso terapéutico , Fumar , Decoloración de Dientes/complicacionesRESUMEN
OBJECTIVES: The aim of this study was to determine the effect on tooth colour (after 1 and 2 weeks use) of a self-applied tooth-whitening gel containing 6% hydrogen peroxide using a novel applicator, compared to a standard fluoride toothpaste. METHODS: A 2-week, examiner-blind, stratified, parallel design clinical trial was conducted. Efficacy was measured by comparing the Vita shade scores recorded at baseline and after 1 and 2 weeks of product application. To qualify for the study, subjects were required to have at least one upper incisor/canine tooth measuring Vita shade A3 or darker. All upper incisors/canines of qualifying subjects were evaluated for change in Vita shade irrespective of their level of whiteness at baseline, allowing for the whitening gel to be tested on the full range of Vita tooth shades. One hundred and seventeen subjects were divided into two groups, balanced according to their darkest tooth shade. One group followed a 2-week, twice-daily regimen of brushing with toothpaste followed by the application of the hydrogen peroxide whitening gel. The other group brushed twice daily with toothpaste for 2 weeks. RESULTS: Subjects using the whitening gel showed a statistically significant improvement, (p<0.05) in mean tooth shade score of 0.75 and 1.02 units after 1 and 2 weeks, compared to baseline. These improvements from baseline were significantly greater than those observed for the toothpaste only group (0.14 and 0.35 units change after 1 and 2 weeks). CONCLUSIONS: The self-applied tooth-whitening gel containing 6% hydrogen peroxide has been shown to significantly improve the whiteness of teeth after 1 and 2 weeks of product use, compared to the baseline and the toothpaste only group.
Asunto(s)
Cariostáticos/uso terapéutico , Fluoruros/uso terapéutico , Peróxido de Hidrógeno/uso terapéutico , Oxidantes/uso terapéutico , Blanqueamiento de Dientes/métodos , Pastas de Dientes/uso terapéutico , Adolescente , Adulto , Análisis de Varianza , Color , Diente Canino/patología , Femenino , Estudios de Seguimiento , Geles , Humanos , Peróxido de Hidrógeno/administración & dosificación , Incisivo/patología , Masculino , Persona de Mediana Edad , Oxidantes/administración & dosificación , Método Simple Ciego , Decoloración de Dientes/terapia , Resultado del TratamientoRESUMEN
OBJECTIVES: The aim of this study was to compare the effect on oral soft tissue of a self-applied tooth whitening gel containing 6% hydrogen peroxide (Xtra White) with a marketed paint-on whitening gel containing 18% carbamide peroxide (Colgate Simply White) after 2-weeks of using products four times daily. METHODS: A 2-week, examiner-blind, stratified, parallel design clinical trial was conducted. Twenty subjects were divided into two groups, balanced according to age and gender. Subjects followed a 2-week, twice-daily regimen of brushing with standard fluoride toothpaste and applied gel product to facial aspects of six upper and six lower incisors/canines, twice in succession with 30 min between applications. Soft tissue examinations were performed on Day 1, before the first application of the test products, and on Day 2, 5, 8 and 15. RESULTS: During the 2-week treatment period, twelve adverse reactions were recorded as potentially attributable to the study products, evenly split between the two test groups. All reports were mild in symptoms and resolved without the need of medical intervention. None of the subjects experiencing an adverse event requested to be withdrawn from the study. CONCLUSIONS: Under the exaggerated use conditions of this test, there was no evidence to suggest that either of the whitening gels produced irritation that was building or developing during the course of the study. It is concluded that both products are safe for their intended use.
Asunto(s)
Peróxido de Hidrógeno/uso terapéutico , Oxidantes/uso terapéutico , Peróxidos/uso terapéutico , Blanqueamiento de Dientes , Urea/análogos & derivados , Urea/uso terapéutico , Adolescente , Adulto , Anciano , Peróxido de Carbamida , Cariostáticos/uso terapéutico , Mezclas Complejas , Dentífricos/uso terapéutico , Combinación de Medicamentos , Femenino , Fluoruros/uso terapéutico , Estudios de Seguimiento , Geles , Humanos , Peróxido de Hidrógeno/administración & dosificación , Masculino , Persona de Mediana Edad , Mucosa Bucal/efectos de los fármacos , Oxidantes/administración & dosificación , Peróxidos/administración & dosificación , Seguridad , Método Simple Ciego , Cepillado Dental , Pastas de Dientes/uso terapéutico , Urea/administración & dosificaciónRESUMEN
A clinical trial was conducted with 25 subjects to evaluate the effects and safety of Zoom! Take-Home whitening gel, a 6% hydrogen peroxide gel for vital tooth bleaching. Tooth bleaching was accomplished using a tray system overnight for 6 nights. Over the 6 nights, a significant change (from darker to lighter) was seen in tooth shades as demonstrated by 3 assessment methods: VITA Shade Value Oriented Guide, Trubyte Bioform Color Ordered Shade Guide scoring system, and the Chroma Meter CR-321 assessments. VITA Shade scores showed a mean change of -6.49 shades (P = .0001) from baseline to day 4 and a -7.72 shades (P = .0001) from baseline to day 7. The Trubyte scores showed a mean change of -9.31 shades (P = .0001) from baseline to day 4 and a -10.77 shades (P = .0001) from baseline to day 7. The Chroma Meter was used to measure tooth color. Analysis of Chroma Meter data showed a significant change in color (delta E), 13.82 mean score change (P = .0001) from baseline to day 4 and a 7.25 mean score change (P = .0001) from baseline to day 7. At day 4 minor tooth sensitivity was reported, and all tooth sensitivity resolved within a few days after treatment.
Asunto(s)
Dispositivos para el Autocuidado Bucal , Blanqueamiento de Dientes/métodos , Adulto , Color/normas , Sensibilidad de la Dentina/etiología , Estudios de Evaluación como Asunto , Femenino , Geles , Humanos , Peróxido de Hidrógeno/administración & dosificación , Masculino , Evaluación de Resultado en la Atención de Salud/métodos , Oxidantes/administración & dosificación , Satisfacción del Paciente , Encuestas y Cuestionarios , Blanqueamiento de Dientes/efectos adversos , Blanqueamiento de Dientes/instrumentaciónRESUMEN
The objective of this clinical study was to compare the whitening/bleaching efficacy of two marketed in-office whitening systems: Discus Dental Zoom! Chairside System (25% hydrogen peroxide whitening gel) and Opalescence Xtra Boost Kit (38% hydrogen peroxide whitening gel), using the Vita Shade Guide and chromameter measurements. The study was an examiner-blind, parallel group, randomized and controlled clinical trial conducted in a dental setting. All subjects signed a study consent form prior to admission and were given Crest Regular Toothpaste and an Oral-B 40 straight-handle toothbrush to use during the study. Subjects received a supragingival prophylaxis followed by a screening eligibility Vita Shade assessment from which 22 subjects were selected. At baseline, all six maxillary anterior teeth were assessed with the Vita Shade Guide. Chromameter measurements were taken on either the right maxillary central or left maxillary central (tooth No. 8 or tooth No. 9). Subjects were assigned to one of two treatment groups, and had three applications of their assigned product. Following completion of the treatment phase, and on post-treatment Days 2 and 7, a visual examination of the condition of the oral soft tissues, together with a Vita Shade assessment on maxillary anterior teeth, a chromameter reading and a questionnaire regarding tooth sensitivity were completed. At the termination of the study, the statistical analysis of the Vita Shade scores indicated that both products significantly (p < 0.0001) lightened the color of the teeth. The average improvement was between 6 and 9 shade changes. Additionally, the Zoom! Chairside System was significantly better than the Opalescense Xtra Boost Kit at all time points: post-treatment (p < 0.0001); Day 2 (p < 0.004); Day 7 (p < 0.003). This difference was between 1 and 2 shade changes. The chromameter readings showed a significant difference in the overall color change (delta E) to a lighter color for both the Zoom! Chairside System and the Opalescence Xtra Boost Kit. Using delta E, the Zoom! Chairside System was directionally better than the Opalescense Xtra Boost Kit at Day 2 (p < 0.08), and significantly better at Day 7 (p < 0.025). Analysis of the composite parameters of delta E (L*, a*, b*) showed that no differences could be detected in the a* (redness) parameter. Changes were observed in the L* (brightness) and b* (yellow) parameters which paralleled the delta E differences. There were no significant differences in induced sensitivity between whitening systems at any time point.