RESUMEN
OBJECTIVES: To test the hypotheses that estimated mean pulmonary arterial pressure (MPAP) decreases and pulmonary vascular maturation, assessed by the ratio of pulmonary arterial flow acceleration time to ejection time (AT/ET ratio), increases after reversal of fetal ductus arteriosus constriction by reducing maternal intake of the causal agent (prostaglandin inhibitors, such as polyphenol-rich foods or non-steroidal anti-inflammatory drugs), and that these effects are independent of gestational age, which are inferences not yet demonstrated in the clinical setting. METHODS: This was a prospective cohort study comparing Doppler echocardiographic ductal flow dynamics, MPAP and pulmonary arterial flow AT/ET ratio in third-trimester fetuses (≥ 28 weeks' gestation) with ductus arteriosus constriction, at the time of diagnosis and after 2 weeks of reduced maternal intake of prostaglandin inhibitors either by suspending the use of pharmacological agents with potential for prostaglandin inhibition or by restricting the consumption of polyphenol-rich foods. MPAP was estimated using the Dabestani equation (MPAP = 90 - (0.62 × AT)), and pulmonary vascular maturity was assessed using the AT/ET ratio, according to reported validation studies. Student's t-test was used for comparison of variables at diagnosis with those after reversal of ductal constriction. Change in MPAP and pulmonary AT/ET ratio between the two assessments was compared with the expected change in the same gestational period in normal fetuses based on reference curves of MPAP and pulmonary AT/ET ratio constructed in normal fetuses from healthy pregnant women at 19-37 weeks' gestation, encompassing the same gestational age range as the study group (28-37 weeks). RESULTS: Seventy pregnancies with fetal ductus arteriosus constriction were included in the study. After 2 weeks of reduced maternal intake of prostaglandin inhibitors, normalization of mean systolic (change from 1.86 ± 0.34 m/s at diagnosis to 1.38 ± 0.41 m/s; P < 0.001) and diastolic (change from 0.41 ± 0.11 m/s to 0.21 ± 0.065 m/s; P < 0.001) ductal velocities and of mean pulsatility index (change from 1.99 ± 0.20 to 2.55 ± 0.42; P < 0.001) was demonstrated. MPAP decreased between the assessments (change from 66.7 ± 6.90 mmHg at diagnosis to 54.5 ± 6.70 mmHg after 2 weeks; P < 0.001) and mean pulmonary AT/ET ratio increased (change from 0.20 ± 0.06 to 0.33 ± 0.07; P < 0.001). Change in MPAP between diagnosis and after 2 weeks of reduced maternal intake of prostaglandin inhibitors was -12.2 ± 0.30 mmHg, which was 5.3-times higher than that in 305 normal fetuses over 2 weeks during the same gestational period (-2.3 ± 0.19 mmHg) (P < 0.001), and change in pulmonary AT/ET ratio between the two assessments was 0.13 ± 0.08, which was 8.7-times higher than that in normal fetuses in the same gestational period (0.015 ± 0.08) (P < 0.001). CONCLUSIONS: Resolution of fetal ductal constriction is followed by a fall in MPAP and by an increase in pulmonary vascular maturity, to a significantly greater degree than is observed in normal fetuses in the same gestational-age period. © 2021 International Society of Ultrasound in Obstetrics and Gynecology.
Asunto(s)
Conducto Arterial/patología , Feto/irrigación sanguínea , Hipertensión Pulmonar/embriología , Atención Prenatal/métodos , Adulto , Presión Arterial , Velocidad del Flujo Sanguíneo , Constricción Patológica/inducido químicamente , Constricción Patológica/embriología , Conducto Arterial/efectos de los fármacos , Conducto Arterial/embriología , Ecocardiografía Doppler , Femenino , Desarrollo Fetal/efectos de los fármacos , Feto/embriología , Edad Gestacional , Humanos , Hipertensión Pulmonar/etiología , Polifenoles/efectos adversos , Embarazo , Estudios Prospectivos , Antagonistas de Prostaglandina/efectos adversos , Arteria Pulmonar/embriología , Arteria Pulmonar/crecimiento & desarrollo , Arteria Pulmonar/fisiopatología , Flujo Pulsátil , Volumen Sistólico , Ultrasonografía PrenatalRESUMEN
Sporotrichosis is a subacute or chronic fungal infection caused by Sporothrix schenckii, which is commonly acquired by traumatic inoculation of the fungus carried in a contaminated material into the skin. Joint involvement is the most frequent extracutaneous manifestation in immunosuppressed patients. We report the case of an immunocompetent woman who acquired sporotrichosis through the scratch of a sick cat. She presented skin lesions and arthritis possibly because of a hypersensitivity reaction. Treatment resulted in complete cure up to 13 months of clinical and serological follow-up.
Asunto(s)
Artritis/inmunología , Artritis/microbiología , Hipersensibilidad/microbiología , Hipersensibilidad/patología , Sporothrix/aislamiento & purificación , Esporotricosis/complicaciones , Esporotricosis/transmisión , Zoonosis/transmisión , Adulto , Animales , Anticuerpos Antifúngicos/sangre , Antifúngicos/uso terapéutico , Artritis/patología , Enfermedades de los Gatos/microbiología , Enfermedades de los Gatos/transmisión , Gatos , Dermatomicosis/inmunología , Dermatomicosis/microbiología , Dermatomicosis/patología , Femenino , Estudios de Seguimiento , Humanos , Inmunoglobulina G/sangre , Esporotricosis/inmunología , Esporotricosis/patología , Resultado del Tratamiento , Zoonosis/microbiologíaRESUMEN
A 10% sample of patients who attended two Primary Health Care Units (PHCU) in Pelotas, RS (Brazil) was studied cross-sectionally for the purpose of measuring qualitatively the attention being offered to the population. According to domicilliar interviews, 15 days after their appointments, a solution (cure or improvement) was achieved in 87.9% of the patients. Patients or parents satisfaction (in the case of pediatric patients) was observed in nearly 90% of the sample. Patient satisfaction and solution were statistically associated (p = 0.04). Association between the solution and the availability of medicines in the PHCU was observed. Patients who had received the whole or a part of their treatment had 33% greater probability of solving their problem. Professional satisfaction was linearly associated with both perception of a better professional-patient relationship (PR = 3.48; CI95%2.17-5.59) and the expectation of a better patient prognosis (PR = 1.99; CI95%1.36-2.91).