1.
Eksp Klin Farmakol
; 67(2): 51-4, 2004.
Artículo
en Ruso
| MEDLINE
| ID: mdl-15188763
RESUMEN
Investigation of the effect of mebavin on the model of adjuvant arthritis showed that this drug administered in a dose of 100 mg/kg exhibits immunomodulant and anti-inflammatory activity without negative influence on the nonspecific response of the organism. Combined administration of mebavin with prednisolone provides for a more effective and nontoxic treatment of adjuvant arthritis.
Asunto(s)
Adyuvantes Inmunológicos/uso terapéutico , Antiinflamatorios/uso terapéutico , Artritis Experimental/tratamiento farmacológico , Bencimidazoles/farmacología , Gosipol/análogos & derivados , Gosipol/uso terapéutico , Adyuvantes Inmunológicos/efectos adversos , Animales , Antiinflamatorios/efectos adversos , Artritis Experimental/inmunología , Quimioterapia Combinada , Gosipol/efectos adversos , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos CBA , Prednisolona/efectos adversos , Prednisolona/uso terapéutico , Ratas , Ratas Wistar , Solubilidad , Agua
2.
Eksp Klin Farmakol
; 66(6): 48-9, 2003.
Artículo
en Ruso
| MEDLINE
| ID: mdl-14743712
RESUMEN
Investigation of the effect of mebavin on the adjuvant arthritis showed that this water-soluble derivative of gossypol possesses an antiinflammatory activity comparable with that of prednisolone.