RESUMEN
An 11-year-old Quarter horse mare was presented for recurrent episodes of colic. A chronic intestinal pseudo-obstruction was diagnosed. Medical treatment and surgical resection of the colon were performed but the condition did not improve and the horse was euthanized. Histopathological examination revealed a myenteric ganglionitis of the small intestine and ascending colon.
Asunto(s)
Seudoobstrucción Colónica/veterinaria , Ganglios Simpáticos/patología , Enfermedades de los Caballos/diagnóstico , Seudoobstrucción Intestinal/veterinaria , Plexo Mientérico/patología , Animales , Enfermedad Crónica , Cólico/etiología , Cólico/veterinaria , Seudoobstrucción Colónica/etiología , Seudoobstrucción Colónica/patología , Seudoobstrucción Colónica/cirugía , Resultado Fatal , Femenino , Enfermedades de los Caballos/patología , Enfermedades de los Caballos/cirugía , Caballos , Seudoobstrucción Intestinal/etiología , Seudoobstrucción Intestinal/patología , Seudoobstrucción Intestinal/cirugíaRESUMEN
This retrospective study evaluated the efficacy and side effects of palatal sclerotherapy in standardbred racehorses suspected to have intermittent dorsal displacement of the soft palate (IDDSP). Fifty-one horses were treated with multiple endoscopically guided injections of 3% sodium tetradecyl sulfate in the soft palate. Two groups were identified: those that had respiratory noises during exercise (n = 27) and those that did not (n = 24). Treatment was well-tolerated. Furthermore, horses significantly reduced their racing times for the last 400 m compared with their times before treatment and even when their times were compared to the mean times for horses in the same race. In conclusion, palatal sclerotherapy appears to be a suitable alternative therapeutic option for horses suspected to have IDDSP.
Asunto(s)
Enfermedades de los Caballos/terapia , Paladar Blando/patología , Condicionamiento Físico Animal/fisiología , Escleroterapia/veterinaria , Tetradecil Sulfato de Sodio/uso terapéutico , Animales , Femenino , Enfermedades de los Caballos/patología , Caballos , Masculino , Paladar Blando/efectos de los fármacos , Ruidos Respiratorios/veterinaria , Estudios Retrospectivos , Escleroterapia/métodos , Resultado del TratamientoRESUMEN
The costochondral junction constitutes a potential site of infection in septic foals and it could be favored by thoracic trauma. Standard radiographs and ultrasonography are useful tools for diagnosis of this condition and ultrasound-guided needle aspiration could permit the definitive confirmation of infection.
Asunto(s)
Enfermedades de los Caballos/diagnóstico , Osteomielitis/veterinaria , Costillas , Animales , Animales Recién Nacidos , Antibacterianos/uso terapéutico , Diagnóstico Diferencial , Femenino , Enfermedades de los Caballos/diagnóstico por imagen , Caballos , Masculino , Osteomielitis/diagnóstico , Osteomielitis/diagnóstico por imagen , Radiografía , UltrasonografíaRESUMEN
Glanzmann thrombasthenia (GT) is characterized by a defect of platelet aggregation. This autosomal recessive genetic disorder is caused by an abnormality of the platelet glycoprotein receptors alpha IIb or beta III. Recently, we identified a horse with clinical and pathological features of GT. The aim of this study was to describe this case of GT at the molecular level. A point mutation from G to C in exon 2 of ITGA2B causing a substitution of the expected amino acid arginine 72 (Arg(72)) by a proline (Pro(72)) was encountered. This amino acid change may result in abnormal structural conformations that yield an inactive alpha IIb subunit. The genomic DNA analysis showed that this horse was homozygous for the missense mutation.
Asunto(s)
Enfermedades de los Caballos/genética , Integrina beta3/genética , Glicoproteína IIb de Membrana Plaquetaria/genética , Trombastenia/veterinaria , Animales , Secuencia de Bases , ADN Complementario/análisis , ADN Complementario/genética , Femenino , Homocigoto , Caballos , Datos de Secuencia Molecular , Mutación Missense , Mutación Puntual , Análisis de Secuencia de ADN/veterinaria , Trombastenia/genéticaRESUMEN
Eastern equine encephalomyelitis (EEE) was diagnosed in 19 horses and a flock of emus in the province of Quebec in fall 2008. The EEE virus caused unusual gross lesions in the central nervous system of one horse. This disease is not usually present in Quebec and the relation between the outbreak and favorable environmental conditions that summer are discussed.
Asunto(s)
Enfermedades de las Aves/epidemiología , Dromaiidae , Encefalomielitis Equina Oriental/veterinaria , Enfermedades de los Caballos/epidemiología , Animales , Enfermedades de las Aves/patología , Brotes de Enfermedades/veterinaria , Virus de la Encefalitis Equina del Este/inmunología , Encefalomielitis Equina Oriental/epidemiología , Encefalomielitis Equina Oriental/patología , Femenino , Enfermedades de los Caballos/patología , Caballos , Masculino , Prevalencia , Quebec/epidemiología , Estaciones del Año , Vacunación/veterinariaRESUMEN
This study was aimed at evaluating the tolerability and the efficacy of palatal sclerotherapy in juvenile standardbred racehorses with easily audible "snoring-like" respiratory noises suspected to be the result of intermittent dorsal displacement of the soft palate. The palate of 8 horses was injected with sodium tetradecyl sulfate under videoendoscopic guidance. Palatal sclerotherapy resulted in resolution of the respiratory noise in 7 horses, improvement of performance in 6 horses, and mild side effects in only 3 horses. This preliminary study suggests that palatal sclerotherapy is a safe, repeatable, inexpensive, and promising technique that should be considered as an alternative to existing treatments of intermittent dorsal displacement of the soft palate.
Asunto(s)
Enfermedades de los Caballos/terapia , Paladar Blando/patología , Condicionamiento Físico Animal/fisiología , Soluciones Esclerosantes/uso terapéutico , Escleroterapia/veterinaria , Tetradecil Sulfato de Sodio/uso terapéutico , Animales , Femenino , Enfermedades de los Caballos/patología , Caballos , Masculino , Paladar Blando/efectos de los fármacos , Complicaciones Posoperatorias/veterinaria , Ruidos Respiratorios/veterinaria , Escleroterapia/métodos , Deportes , Resultado del TratamientoRESUMEN
An 18-month-old Oldenbourg filly was presented with a bleeding diathesis. Laboratory testing included platelet count, gingival bleeding time, prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor (vWf) antigen, clottable fibrinogen, clot retraction time, PFA-100 closure time, platelet aggregometry (on platelet-rich plasma), and thrombelastography (TEG). TEG was performed by using kaolin and tissue factor as coagulation activators. Expression of the platelet receptor for fibrinogen was assessed by flow cytometry by using anti CD41 (alpha(IIb) or glycoprotein IIb)/CD61 (beta(III) or glycoprotein IIIa) and anti-CD41 antibodies. Abnormal laboratory findings included prolonged oral mucosal bleeding time (>12 hours), prolonged closure time with collagen/ADP (>300 seconds), and absence of clot retraction after 60 minutes. TEG reaction times were similar with kaolin and tissue factor in the patient and a control horse. However, maximum amplitudes in the patient were decreased with both kaolin (43.7 mm; control, 63.9 mm) and tissue factor (37.7 mm; control, 57.8 mm). Platelet aggregation responses to ADP and collagen were profoundly reduced in the affected horse compared with a control. Flow cytometry showed an absence of CD41 and decreased expression of CD41/CD61-reacting antigen on the patient's platelets compared with those from a control horse. The laboratory findings supported a diagnosis of Glanzmann thrombasthenia, likely caused by a mutation in the gene encoding the GPIIb subunit.