RESUMEN
Pyoderma gangrenosum (PG) is a rare ulcerative skin condition. It can be associated with a number of systemic diseases. Association with monoclonal gammopathy of undetermined significance (MGUS) is uncommon, but prognosis may be different depending upon the type of MGUS. Cases of MGUS- related PG reported in the literature with data concerning evolution and treatment were identified through a PubMed search. A patient with recurrent PG in the setting of a MGUS-IgA-? in our department was also included. In total, 10 cases were identified. Only the two cases with Ig populations other than IgA improved without recurrence after treatment of the PG. All the patients with MGUS-IgA showed recurrences. Early multiple myeloma was proposed for three patients with MGUS-IgA-related PG. Second or third line treatments were necessary in some cases.
Asunto(s)
Glucocorticoides/uso terapéutico , Gammopatía Monoclonal de Relevancia Indeterminada/complicaciones , Prednisolona/uso terapéutico , Piodermia Gangrenosa/tratamiento farmacológico , Humanos , Masculino , Persona de Mediana Edad , Mieloma Múltiple/etiología , Piodermia Gangrenosa/complicaciones , RecurrenciaRESUMEN
Hidradenitis suppurativa is an inflammatory disease of the pilosebaceous unit with a chronic intermittent course and a devastating effect on quality of life. Rare reports of drug-induced hidradenitis suppurativa exist. We report on 2 women on follow-up for rheumatoid arthritis, who presented hidradenitis suppurativa after different periods of treatment with leflunomide and who improved few weeks after discontinuation of the medication.
Asunto(s)
Malformaciones Arteriovenosas/complicaciones , Epistaxis/complicaciones , Arteria Hepática/anomalías , Venas Hepáticas/anomalías , Sistema Porta/anomalías , Telangiectasia Hemorrágica Hereditaria/complicaciones , Malformaciones Arteriovenosas/diagnóstico por imagen , Arteria Hepática/diagnóstico por imagen , Venas Hepáticas/diagnóstico por imagen , Humanos , Masculino , Persona de Mediana Edad , Sistema Porta/diagnóstico por imagen , Telangiectasia Hemorrágica Hereditaria/diagnóstico por imagenRESUMEN
Tuberculous gummas are an unusual form of tuberculosis (TB) accounting for 1%-2% of all cutaneous TB cases. The aim of this article was to describe the epidemiological, clinical, bacteriological, immunological, and therapeutic features of this form upon a case report and a literature review. Forty-eight case reports were identified through a PubMed and Google Scholar search using the following keywords: "tuberculous gumma" and "metastatic tuberculous abscesse." Tuberculous gumma can occur at any age. Immunodepression is not a sine qua non condition to the development of the disease. Limbs are the most frequent site for gummas. Tuberculous gummas are associated to another location in only 73% of cases. The most frequent associated locations are lung, nodes, and musculoskeletal apparatus. Mantoux test is negative in 38% of cases. Skin stain is positive in 45% of cases and culture in 85% of cases. Giant epithelioid cell granuloma is present in 82.4% of cases. There is no universally accepted chemotherapy regimen for metastatic tuberculous abscesses. The classic 2RHZE/4RH is highly effective.