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RESUMO A alimentação adequada e saudável é crucial para o desenvolvimento infantil, principalmente nos primeiros mil dias de vida. Sendo a alimentação não saudável um fator de risco modificável para doenças e desnutrição, ações que promovam as orientações do 'Guia alimentar para crianças brasileiras menores de 2 anos' são necessárias. O presente relato compartilha o processo de planejamento, construção, divulgação, oferecimento e avaliação de uma oficina virtual para profissionais da Atenção Primária à Saúde no Acre, Amazônia Ocidental brasileira, com destaque para os desafios encontrados e as lições aprendidas. A oficina contou com 170 inscritos e foi assíncrona para facilitar o acesso dos participantes diante da baixa disponibilidade de tempo e instabilidade do sinal de internet na região. O uso de diferentes ferramentas virtuais favoreceu o diálogo entre os participantes e as coordenadoras da oficina. Participantes relataram preferir vídeos curtos com animações, e os conteúdos considerados mais importantes abordaram avaliação antropométrica, processamento e classificação de alimentos e desafios da alimentação. Ressalta-se a importância das parcerias com secretarias de saúde para o adequado planejamento e divulgação da oficina, e da colaboração de pesquisadoras e profissionais da área para a definição e elaboração de conteúdo relevante.

ABSTRACT Adequate and healthy nutrition is crucial for child development, especially in the first 1,000 days of life. Since unhealthy eating is a modifiable risk factor for diseases and malnutrition, actions that promote the guidelines of the 'Food guide for Brazilian children under 2 years old' are necessary. This report shares the process of planning, building, disseminating, offering, and evaluating a virtual workshop for professionals in Primary Health Care in Acre, Western Brazilian Amazon, highlighting the challenges encountered and lessons learned. The workshop had 170 participants and was asynchronous to facilitate access for participants given the low availability of time and instability of the internet signal in the region. The use of different virtual tools favored dialogue between the participants and the workshop coordinators. Participants reported preferring short videos with animations, and the content considered most important addressed anthropometric assessment, food processing and classification, and food challenges. The importance of partnerships with health departments is highlighted for the adequate planning and dissemination of the workshop, and the collaboration of researchers and professionals in the field for the definition and elaboration of relevant content.

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Low back pain (LBP) is a painful manifestation in the lower part of the spine which causes disabilities changing the sensitivity of sensory neurons resulting in weakness of postural muscles interfering with the balance. It is not already clear if LBP people's muscle changes affect the centre of pressure (CoP) recovery in challenging stance perturbations. The aim of this study was to identify differences in the muscle reactions of people with and without LBP to control CoP in challenging stance perturbations. We applied low (Vel1) and high (Vel2) magnitude stance perturbation by a movable platform and evaluated (a) the magnitude and latency time of trunk and lower limb muscle activation, (b) and the displacement and the latency time of the first CoP peak. The latency of trunk and hip muscle activation on Vel2 was lower for LBP group. The CoP latency and displacement did not change between groups and velocities indicating that the muscles took the same time to overcome the external forces. In conclusion, the maintenance of CoP latency at both velocities was not affected on Vel2, suggesting that such alterations have protective action and preservation of the pain on the LPB group in challenging stance perturbations.

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CONTEXT: Volleyball and handball players have usually been studied collectively as "overhead athletes," since throwing present similarities in the proximal to distal movement sequencing and upper limb joints ranges of motion. However, each sport presents specificities in the objectives when accelerating the ball and a variety of possible throwing techniques. Therefore, it is expected there may be differences in the shoulder and upper body physical performance between sports. OBJECTIVE: The aim of this study was to determine if there are differences in shoulder muscle strength and upper body field performance tests between volleyball and handball athletes. DESIGN: Cross-sectional. METHODS: Ninety-nine volleyball and handball female athletes aged between 13 and 20 years were evaluated for isometric shoulder abductor and rotator strength (handheld dynamometer) and upper body field performance tests: Y Balance Test-Upper Quarter, modified Closed Kinetic Chain Upper-Extremity Stability Test, and unilateral and bilateral Seated Medicine Ball Throw. RESULTS: Handball athletes presented greater shoulder internal rotation strength (between-group difference: 2.84; effect size 0.70), higher medial (between-group difference: 9.54; effect size 0.90), superolateral (between-group differences: 8.9; effect size 0.68), and composite scores (between-group difference 5.7; effect size 0.75) of the Y Balance Test-Upper Quarter and higher unilateral (between-group difference: 41.92; effect size 0.91) and bilateral (between-group difference: 46.11; effect size 0.83) Seated Medicine Ball Throw performance. Groups were not different for Closed Kinetic Chain Upper-Extremity Stability Test, external rotation, and abduction isometric strength. CONCLUSION: Our findings suggest that young female handball athletes present greater internal rotator strength and better performance in Y Balance Test-Upper Quarter and Seated Medicine Ball Throw compared to volleyball players. These differences may be related to the different demands required in the throwing movements performed in each sport and should be considered when assessing these populations.

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We sought to investigate the effects of resistance training (RT) combined with erythropoietin (EPO) and iron sulfate on the hemoglobin, hepcidin, ferritin, iron status, and inflammatory profile in older individuals with end-stage renal disease (ESRD). ESRD patients (n: 157; age: 66.8 ± 3.6; body mass: 73 ± 15; body mass index: 27 ± 3), were assigned to control (CTL; n: 76) and exercise groups (RT; n: 81). The CTL group was divided according to the iron treatment received: without iron treatment (CTL-none; n = 19), treated only with iron sulfate or EPO (CTL-EPO or IRON; n = 19), and treated with both iron sulfate and EPO (CTL-EPO + IRON; n = 76). The RT group followed the same pattern: (RT-none; n = 20), (RT-EPO or IRON; n = 18), and (RT-EPO + IRON; n = 86). RT consisted of 24 weeks/3 days per week at moderate intensity of full-body resistance exercises prior to the hemodialysis section. The RT group, regardless of the iron treatment, improved iron metabolism in older individuals with ESRD. These results provide some clues on the effects of RT and its combination with EPO and iron sulfate in this population, highlighting RT as an important coadjutant in ESRD-iron deficiency.

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OBJECTIVE: To assess how mothers classify foods and how their eating practices interact with these classifications, with special attention to meanings and uses given to ultra-processed foods. DESIGN: Qualitative research with in-depth interviews and pile sorts. SETTING: Urban Brazilian Amazon. PARTICIPANTS: A sample of 34 mothers were selected through theoretical sampling. ANALYSIS: Content analysis for in-depth interviews and multidimensional scaling and cluster analysis for pile sorts. PHENOMENON OF INTEREST: Food classification. RESULTS: Classifications were based on context (ie, a time or a situation in which the food is eaten) and foods' healthiness. Five food groupings based on mothers' classifications were defined: (1) main meal foods, (2) fruits and fruit juices, (3) convenient foods, (4) leisure foods, and (5) canned sardines. Ultra-processed foods were classified differently from non-ultra-processed foods and considered unhealthy, consumed on special occasions or when there was no time or desire to cook. CONCLUSIONS AND IMPLICATIONS: Results highlight the potential of incorporating context-based categories and personal experiences to guide nutrition interventions and the potential of pile sorts to tailor messages to target populations.

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Extensive testing of populations against COVID-19 has been suggested as a game-changer quest to control the spread of this contagious disease and to avoid further disruption in our social, healthcare and economical systems. Nonetheless, testing millions of people for a new virus brings about quite a few challenges. The development of effective tests for the new coronavirus has become a worldwide task that relies on recent discoveries and lessons learned from past outbreaks. In this work, we review the most recent publications on microfluidics devices for the detection of viruses. The topics of discussion include different detection approaches, methods of signalling and fabrication techniques. Besides the miniaturization of traditional benchtop detection assays, approaches such as electrochemical analyses, field-effect transistors and resistive pulse sensors are considered. For emergency fabrication of quick test kits, the local capabilities must be evaluated, and the joint work of universities, industries, and governments seems to be an unequivocal necessity.

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OBJECTIVE: To analyze the scientific literature produced on health education through mobile applications for surgical patients. METHOD: An integrative literature review performed through consultation in the following portals and/or databases: VHL; PubMed; Web of Science; Scopus; LILACS and CINAHL. The search was guided by the question: "What is the evidence on the use of mobile applications in the health education of surgical patients?" conducted from July to September 2017, including articles published from the year 2000 to 2017. RESULTS: Five articles published in international journals in English with varied methodological designs were selected. Among the studies found, 60% used an educational intervention through smartphone applications in the pre and postoperative periods, and 40% of the studies had an evidence level of 2B. CONCLUSION: The studies showed that the use of smartphone applications in educating and guiding surgical patients was effective. However, there is still a gap in studies which demonstrate surgical patient education through smartphone applications.

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Abstract OBJECTIVE To analyze the scientific literature produced on health education through mobile applications for surgical patients. METHOD An integrative literature review performed through consultation in the following portals and/or databases: VHL; PubMed; Web of Science; Scopus; LILACS and CINAHL. The search was guided by the question: "What is the evidence on the use of mobile applications in the health education of surgical patients?" conducted from July to September 2017, including articles published from the year 2000 to 2017. RESULTS Five articles published in international journals in English with varied methodological designs were selected. Among the studies found, 60% used an educational intervention through smartphone applications in the pre and postoperative periods, and 40% of the studies had an evidence level of 2B. CONCLUSION The studies showed that the use of smartphone applications in educating and guiding surgical patients was effective. However, there is still a gap in studies which demonstrate surgical patient education through smartphone applications.

Resumen OBJETIVO Analizar la literatura científica producida acerca de la educación en salud por medio de aplicaciones de teléfono celular para pacientes quirúrgicos. MÉTODO Revisión integrativa de la literatura, realizada mediante consulta en las páginas web y/o bases de datos: BVS; PubMed; Web of Science; Scopus; LILACS y CINAHL. La búsqueda fue orientada por la pregunta: "¿Cuáles son las evidencias del empleo de aplicaciones de teléfonos celulares en la educación en salud de pacientes quirúrgicos?" y llevada a cabo en el período de julio a septiembre de 2017, incluyéndose artículos publicados desde el año 2000 hasta el 2017. RESULTADOS Fueron seleccionados cinco artículos publicados en periódicos internacionales en inglés, con diseños metodológicos variados. Entre los estudios encontrados, el 60% utilizaron la intervención educativa mediante aplicaciones de smartphone en los períodos pre y posoperatorio. Se observó que el 40% de los estudios presentaron nivel de evidencia 2B. CONCLUSIÓN Los estudios mostraron que el empleo de aplicaciones de smartphone en la educación y orientación del paciente quirúrgico fue efectivo. Aun así existe una laguna de estudios que evidencien la práctica de educación del paciente quirúrgico mediante aplicaciones de smartphone.

Resumo OBJETIVO Analisar a literatura científica produzida sobre educação em saúde por meio de aplicativos de celular para pacientes cirúrgicos. MÉTODO Revisão integrativa da literatura, realizada por meio de consulta nos portais e/ou bases de dados: BVS; PubMed; Web of Science; Scopus; LILACS e CINAHL. A busca foi norteada pela pergunta: "Quais as evidências do uso de aplicativos em celulares na educação em saúde de pacientes cirúrgicos?" e realizada no período de julho a setembro de 2017, incluindo artigos publicados a partir do ano de 2000 até 2017. RESULTADOS Foram selecionados cinco artigos publicados em periódicos internacionais em inglês, com desenhos metodológicos variados. Entre os estudos encontrados, 60% utilizaram a intervenção educativa por meio de aplicativos de smartphone nos períodos pré e pós-operatório. Observou-se que 40% dos estudos tiveram nível de evidência 2B. CONCLUSÃO Os estudos mostraram que o uso de aplicativos de smartphone na educação e orientação do paciente cirúrgico foi efetivo. Ainda assim, há uma lacuna de estudos que evidenciem a prática de educação do paciente cirúrgico por meio de aplicativos de smartphone.

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Objetivo: avaliar os fatores aliviantes e agravantes do estresse relacionado ao trabalho da equipe de enfermagem. Metodologia: revisão integrativa de acordo com a declaração PRISMA a partir de artigos oriundos das bases de dados PubMed e Bireme. Foram analisados artigos de 2014 a 2018, em português ou língua estrangeira. Foi realizada estatística descritiva. Resultados: a proporção de estresse na equipe de enfermagem variou de 32% a 88%. Os fatores citados como causadores de estresse no ambiente de trabalho foram: conflitos com paciente, médico e outros profissionais 72,2% (n=13); sobrecarga de trabalho 66,7% (n=12); desvalorização profissional 38,9% (n=07), entre outros. Metade dos estudos 50% (n=4) detectaram dificuldade de dormir, enxaqueca, irritação, seguido por fadiga, perda da concentração e cansaço mental em 37,5% (n=3). A formas utilizadas pelos profissionais de enfermagem para alívio do estresse, o mais mencionado com 66,7% (n=4) foi momentos de distração, seguida de descanso e conversa 50% (n=3). Conclusões: o estresse é frequente entre trabalhadores de enfermagem. Os principais causadores de estresse são conflitos com paciente, médico e outros profissionais. Os sintomas mais comuns relacionados ao estresse são dificuldade de dormir, enxaqueca e irritação.

Objective: to evaluate the relieved and aggravating factors of stress related to the work of the nursing team. Methodology: this is an integrative review according to the PRISMA statement from articles of PubMed and Bireme databases. Articles from 2014 to 2018, in Portuguese or in a foreign language, were analyzed. Descriptive statistics were performed. Results: the proportion of stress in the nursing team ranged from 32% to 88%. Factors cited as causing stress in the work environment were: conflicts with patient, physician and other professionals 72.2% (n=13); work overload 66.7% (n=12); professional devaluation 38.9% (n=07), among others. Half of the studies 50% (n=4) detected difficulty sleeping, migraine, irritation, followed by fatigue, loss of concentration and mental fatigue in 37.5% (n=3). The forms used by nursing professionals for stress relief, the most mentioned with 66.7% (n=4) were moments of distraction, followed by rest and conversation 50% (n=3). Conclusions: stress is frequent among nursing workers. The main causes of stress are conflicts with patient, doctor and other professionals. The most common symptoms related to stress are difficulty sleeping, migraine and irritation.

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Objetivo: avaliar a formação dos discentes do último período do curso de Enfermagem quanto à avaliação da dor. Método: trata-se de um estudo quantitativo, descritivo, transversal, desenvolvido em uma instituição de ensino privada. Compôs-se a amostra por 169 graduandos do décimo período. Utilizou-se um formulário com questões objetivas. Realizou-se a análise descritiva univariada a partir de tabelas. Resultados: constata-se que a dor foi ensinada pelos docentes como o quinto sinal vital para 52,1% dos participantes; 76% afirmaram que, no estágio curricular obrigatório, não observaram o registro da dor nos prontuários; 68% não foram estimulados a utilizar as escalas para a avaliação da dor e 62,1% nunca utilizaram as escalas para a avaliação da dor. Entende-se que muitos acadêmicos de Enfermagem, no último semestre da graduação, não se sentem aptos a realizar a avaliação da dor. Conclusão: encontram-se falhas no conhecimento dos graduandos de Enfermagem no tocante à avaliação da dor, e é preocupante a formação desses enfermeiros, considerando que a avaliação da dor e o seu controle são princípios básicos para uma assistência de qualidade.(AU)

Objective: to evaluate the training of students from the last semester of the Nursing undergraduate course regarding pain assessment. Method: this is a quantitative, descriptive, cross-sectional study, developed in a private educational institution. The sample consisted of 169 students from the last semester, who answered a form with objective questions. The univariate descriptive analysis was performed from tables. Results: professors teah pain as the fifth vital sign for 52.1% of the participants; 76% stated not observing pain record on medical charts in the curricular mandatory internship; 68% were not encouraged to use the scales for pain assessment and 62.1% have never used the scales for pain assessment. Many Nursing undergraduate students, in the last semester, do not feel able to carry out pain assessment. Conclusion: Nursing graduates' knowledge present gaps in relation to pain assessment, whose training is worrying, considering pain assessment and control as basic principles for quality assistance.(AU)

Objetivo: evaluar la formación de los estudiantes del último período del curso de enfermería en la evaluación del dolor. Método: se trata de un estudio cuantitativo, descriptivo, transversal, desarrollado en una institución de enseñanza privada. La muestra estuvo compuesta por 169 estudiantes del 10º período. Se utilizó un formulario con preguntas objetivas. El análisis descriptivo univariado de tablas. Resultados: se observó que el dolor era enseñada por los profesores como el quinto signo vital para 52,1% de los participantes; 76% afirmaron que, en la práctica laboral curricular obligatoria, no observaron el registro del dolor en los cuadros; 68% no fueron estimulados a usar las escalas de evaluación del dolor y 62,1% nunca han utilizado las escalas para la evaluación del dolor. Se entiende que muchos universitarios de enfermería, en el último semestre de graduación, no se sienten capaces de llevar a cabo la evaluación del dolor. Conclusión: existen lagunas en el conocimiento de los graduados de enfermería en relación con la evaluación del dolor, y es preocupante la formación de estos enfermeros, mientras que la evaluación del dolor y su control son los principios básicos para la calidad de la asistencia.(AU)

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In view of the relevance of adequate pain management in the evolution of the clinical picture of children, this study aimsto emphasize, for health professionals, the importance of using the Analgesic Ladder and pain assessment scale andtheir recording. The objective of this study was to evaluate the therapeutic suitability of the analgesic used accordingto the Pain Management Index, to the intensity and to pain reported by children submitted to a surgical procedure.An exploratory and quantitative study was carried out in which the sample consisted of 31 children from 5 to 12years of age in the immediate postoperative period. The data collection instrument was composed of questions aboutsociodemographic and clinical data. Pain assessment occurred for 3 consecutive days. The univariate descriptiveanalysis was performed and the results were presented in the form of graphs and tables. A high prevalence of pain wasfound in the first (48%) and third (45%) postoperative days, with a greater pain intensity on the first day (moderate tointense - 49%). On the first day the children presented greater analgesic inadequacies and the registration of pain inthe medical records did not correspond to the amount of reports. These inadequacies constitute an important challengefor children’s postoperative success. This study serves as a subsidy for improvements in the quality of the postoperative care of children

Diante da relevância do manejo adequado da dor na evolução do quadro clínico da criança, este estudo visa ressaltarpara os profissionais da saúde a importância da utilização da escada analgésica, escala de avaliação da dor e deseu registro. O objetivo deste estudo foi avaliar a adequação terapêutica do analgésico de acordo com o Índice deManejo da Dor, a intensidade e o registro de dor em crianças submetidas a procedimento cirúrgico. Foi realizadoum estudo exploratório e quantitativo, cuja amostra foi constituída por 31 crianças de 5 a 12 anos em pós-operatóriomediato. O instrumento de coleta de dados foi composto por questões sobre dados sociodemográficos e clínicos. Aavaliação de dor ocorreu durante 3 dias consecutivos. Realizou-se a análise descritiva univariada e os resultados foramapresentados na forma de gráfico e tabelas. Constatou-se alta prevalência de dor no primeiro (48%) e terceiro (45%)dia de pós-operatório, com maior intensidade de dor no primeiro dia (moderada à intensa - 49%). No primeiro diaas crianças apresentaram maiores inadequações analgésicas e os registros de dor no prontuário não condiziam coma quantidade de relatos. Essas inadequações, constituindo um importante desafio para o sucesso no pós-operatórioinfantil. Este estudo serve de subsídio para melhorias na qualidade do cuidado pós-operatório de crianças

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OBJECTIVE: The aim of this article is to analyze the influence of the variability of the standard time in the simulation of the assembly operations of manufacturing systems. BACKGROUND: Discrete event simulation (DES) has been used to provide efficient analysis during the design of a process or scenario. However, the modeling activities of new configurations face the problem of data availability and reliability when it comes to seeking standard times that are effective in representing the actual process under analysis, especially when the process cannot be monitored. METHOD: The methods-time measurement (MTM) is used as a source of standard times for simulation. Assembly activities were performed at a Learning Factory facility, which provided the necessary structure for simulating real production processes. Simulation performances using different variability of standard times were analyzed to define the impact of data characteristics. RESULTS: The MTM standard time presented an error of approximately 5%. The definition of the data variability of standard times and the statistical distribution impacts were shown in the simulation results, with errors above 6% being observed, interfering with the model reliability. CONCLUSION: Based on the study, to increase the adherence of a simulation to represent a real process, it is recommended to use triangular distributions with central values greater than those established via the MTM for the representation of the standard times of new assembly processes or scenarios using DES. APPLICATION: The study contributions can be applied in assembly line design, providing a reliable model representing real processes and scenarios.

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O objetivo deste estudo foi avaliar os fatores sociodemográficos, clínicos e cirúrgicos relacionados com a intensidade da dor no pós-operatório de crianças. Estudo descritivo e exploratório com abordagem quantitativa, realizado com 31 crianças de cinco a 12 anos nas primeiras 72 horas de pós-operatório utilizou-se um questionário com perguntas clínicas, sociodemográficas e as escalas de faces e numérica de dor. Foram realizados os testes Qui-quadrado e Exato de Fisher para a análise dos resultados. Evidenciou-se que o tipo de cirurgia realizada influencia significativamente (p-valor= 0,036) na presença de dor nas 24h, após a cirurgia. A intensidade da dor com o tipo de cirurgia nos dois primeiros dias de pós-operatório apresentou valor significativo (p-valor=0,044) no primeiro dia e (p-valor=0,021) no segundo. No 2º dia de internação, a variável sexo (feminino) mostrou diferença significativa com relação à média de intensidade de dor (p-valor=0,032) e no 3º dia, a característica clínica que se fez significativa foram os antecedentes patológicos (p-valor=0,031) quando relacionado à intensidade da dor. Conclui-se que as variáveis sociodemográficas, clínica e cirúrgica interferem na presença e intensidade de dor em crianças no pós-operatório, principalmente tipo de cirurgia, sexo e antecedentes patológicos

The aim of this study is evaluating the socio-demographic, clinical and surgical factors related to the pain intensity in the children´s post-surgery. Descriptive and exploratory study with a quantitative approach conducted with 31 five to twelve-year-old children in the first 72 hours of the post-surgery, where it was applied a questionnaire with clinical and socio- demographic questions, and the face and numerical scales of pain. The Chi-square and the Fischer Exact tests were used for the analysis of the results. It was observed that the kind of surgery performed influences significantly (p-value= 0.036) in the presence of pain in the first 24 hours, after the surgery. The intensity of pain with the kind of surgery in the first two post-surgery days presented a significant value (p-value=0.044) in the first day and (p-value=0.021) in the second day. In the 2nd day of admission the variable sex (female) showed a significant difference in relation to the intensity of pain average (p-value=0.032), and in the 3rd day the significant characteristic was the pathological background (p-value=0.031) when related to the intensity of pain. It is concluded that socio-demographic, clinical and surgical variables interfere in the presence and intensity of pain in children in post-surgery, especially kind of surgery and pathological background

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ABSTRACT BACKGROUND AND OBJECTIVES: The difficulty of the nursing staff in assessing pain, the low adherence to the registry of pain and the quality reported in other studies brings the need to assess the related factors and one of them can be the lack of knowledge. The objective of this study was to evaluate the knowledge of nursing students about pain assessment. METHODS: A cross-sectional, descriptive and quantitative study, conducted in a Higher Education School in Aracaju, Brazil. The sample was composed of 169 nursing students over the last period of graduation. The data were obtained through a form that contained sociodemographic information, questions about pain assessment, and knowledge sources used. RESULTS: The scales to assess pain in children and in adults are known by 70 and 66% of the students, respectively. They reported that pain assessment and the incorrect pain treatment may impair the clinical picture and aggravate the disease, both in the child (17.2%) and the adult (15.4%). The rate of correct answers about pain assessment ranged from 26.6 to 87%. Most of them use articles to gain knowledge about pain (56.2%). The fact of having already used a scale to assess the patient's pain (p=0.045) showed significant differences in the average of hits. CONCLUSION: Nursing graduates are aware of the existence of scales to assess pain, but they do not have the ability to perform them. The prior use of scales promotes learning. The lack of knowledge about pain impacts on the patient's health.

RESUMO JUSTIFICATIVA E OBJETIVOS: A dificuldade da equipe de enfermagem em avaliar a dor, a baixa adesão ao registro de dor e a sua qualidade relatada em outros estudos, faz surgir a necessidade de avaliar os fatores relacionados, podendo ser um deles a deficiência de conhecimento. O objetivo deste estudo foi avaliar o conhecimento dos estudantes de enfermagem sobre a avaliação da dor. MÉTODOS: Estudo transversal, descritivo e quantitativo, desenvolvido em uma instituição de ensino superior em Aracaju, SE, Brasil. A amostra foi composta por 169 acadêmicos de enfermagem do último período da graduação. Os dados foram obtidos por meio de formulário que continha questões sociodemográficas, perguntas sobre a avaliação da dor e as fontes de conhecimento utilizadas. RESULTADOS: As escalas para avaliação da dor na criança e no adulto são conhecidas por 70 e 66% dos acadêmicos, respectivamente. Eles relataram que a avaliação e o tratamento inadequado da dor podem prejudicar o quadro clínico e agravar a doença tanto na criança (17,2%) quanto no adulto (15,4%). O índice de acertos sobre a avaliação da dor variou entre 26,6 e 87%. A maioria deles utiliza artigos para adquirir conhecimento sobre a dor (56,2%). Já ter utilizado escala para avaliação da dor do paciente (p=0,045) apresentou diferenças significativas na média de acertos. CONCLUSÃO: Os formandos de enfermagem sabem da existência das escalas para avaliação da dor, porém não possuem habilidade para executá-las. A utilização prévia de escalas favorece o aprendizado. O baixo conhecimento quanto à dor repercute na saúde do paciente.

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O estresse oxidativo está relacionado ao desenvolvimento de muitas enfermidades e atualmente tem-se utilizado a Diosmina visando reduzi-lo. O objetivo deste estudo é identificar através da literatura o efeito antioxidante da Diosmina. Trata-se de um estudo descritivo bibliográfico de revisão integrativa, realizada a partir artigos que abordassem o tema pesquisado publicados entre 2013 a 2017 oriundos das bases de dados eletrônicas PubMed e Bireme. Foram analisados 9 artigos. Os estudos avaliados evidenciam que com a utilização da Diosmina há uma elevação da quantidade no organismo de enzimas que combatem o estresse oxidativo como, catalase e outras. E também que ocorreu a redução do Malondialdeído. Conclui-se com esse estudo que a Diosmina contribui para o combate das lesões desencadeadas pelo desequilíbio no status redox que estimula o aumento de antioxidantes enzimáticos e inibe a formação de malondialdeído, assim colaborando para a diminuição de danos aos tecidos.

Oxidative stress is related to the development of multiple diseases and some studies objective to identify the effect of natural substances in lesions caused by it. One of these substances is Diosmin, a flavonoid found in citric fruits. The objective of this study was to identify through the literature the anti-oxidative effect of Diosmin. It is a descriptive and bibliographic study of integrative revision, based on articles which discussed the researched topic published between 2013 and 2017 using the electronic database PubMed and Bireme. 9 articles were analyzed. The studies evaluated show that the use of Diosmin rises the activity of enzymes which fight against oxidative stress, as catalase, superoxide dismutase and glutathione. There was reduction of the concentration of malondialdehyde. It was proved with this study that Diosmin contributes to the fight against lesions caused by the unbalance between the redox status, stimulating the rise of activity of enzymatic anti-oxidants and reducing the production of malondialdehyde, collaborating to the reduction of damage to tissues generated by stress oxidative.

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Electrochemotherapy is an anticancer treatment based on applying electric field pulses that reduce cell membrane selectivity, allowing chemotherapy drugs to enter the cells. In parallel to electrochemotherapy clinical tests, in silico experiments have helped scientists and clinicians to understand the electric field distribution through anatomically complex regions of the body. In particular, these in silico experiments allow clinicians to predict problems that may arise in treatment effectiveness. The current work presents a metastatic case of a mast cell tumor in a dog. In this specific treatment planning study, we show that using needle electrodes has a possible pitfall. The macroscopic consequence of the electroporation was assessed through a mathematical model of tissue electrical conductivity. Considering the electrical and geometrical characteristics of the case under study, we modeled an ellipsoidal tumor. Initial simulations were based on the European Standard Operating Procedures for electrochemotherapy suggestions, and then different electrodes' arrangements were evaluated. To avoid blind spots, multiple applications are usually required for large tumors, demanding electrode repositioning. An effective treatment electroporates all the tumor cells. Partially and slightly overlapping the areas increases the session's duration but also likely increases the treatment's effectiveness. It is worth noting that for a single application, the needles should not be placed close to the tumor's borders because effectiveness is highly likely to be lost.

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Rabdomiólise é uma condição aguda com lesão muscular esquelética e liberação de toxinas produzidas pelos miócitos. A apresentação clínica é variada (desde elevações assintomáticas de marcadores de injúria muscular, com a creatina fosfoquinase (CPK), até distúrbios hidroeletrolíticos graves com ou sem insuficiência renal aguda. As etiologias envolvem desde medicamentos como atividades físicas extenuantes. O diagnóstico é clínico-laboratorial, chamando a atenção para níveis aumentados de enzimas musculares, especialmente a reatinofosfoquinase. A principal complicação clínica é a insuficiência renal aguda e o diagnóstico precoce é fundamental para a instituição de medidas terapêuticas eficazes. Relatamos o caso de um paciente jovem, com rabdomiólisepós exercício físico (musculação), com altos índices de reatinofosfoquinase (239.000U/L), sem evolução para insuficiência renal aguda (IRA), contrariamente ao esperado pelos valores isolados de reatinofosfoquinase.

Rhabdomyolysis is a acute condition with muscle injury and liberation of toxins produced by myocytes. The clinical presentation is wide (from asymptomatic elevations in laboratorial markers of muscle injury, like creatine kinase (CK), to severe electrolyte disturbances with or without acute renal failure). The etiologies involve from medications to strenuous physical activity. The diagnosis is clinical and laboratorial, which have attention to the increased levels of muscle enzymes, especially the CPK. The main clinical complication is acute renal failure and early diagnosis is critical for the establishment of effective therapeutic measures. We report the case of a young patient with rhabdomyolysis after exercise (weightlifting), with high levels of CPK (239.000U/L) without denvelopment to acute renal failure (ARF), contrary to the expected with isolated values of CPK only.

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New strategies for skin regeneration are needed in order to provide effective treatment for cutaneous wounds and disease. Mesenchymal stem cells (MSCs) are an attractive source of cells for tissue engineering because of their prolonged self-renewal capacity, multipotentiality, and ability to release active molecules important for tissue repair. In this paper, we show that human skin-derived mesenchymal stromal cells (SD-MSCs) display similar characteristics to the multipotent MSCs. We also evaluate their growth in a three-dimensional (3D) culture system with dermal substitutes (Integra and Pelnac). When cultured in monolayers, SD-MSCs expressed mesenchymal markers, such as CD105, Fibronectin, and α-SMA; and neural markers, such as Nestin and ßIII-Tubulin; at transcriptional and/or protein level. Integra and Pelnac equally supported the adhesion, spread and growth of human SD-MSCs in 3D culture, maintaining the MSC characteristics and the expression of multilineage markers. Therefore, dermal substitutes support the growth of mesenchymal stromal cells from human skin, promising an effective tool for tissue engineering and regenerative technology.

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Os autores apresentam o caso de uma paciente de 42 anos,portadora de Retocolite Ulcerativa Inespecífica (RCUI) assintomática há 6 anos, sem tratamento adequado. Foi internada após surgirem sintomas da doença em atividade (febre, astenia, diarreia sanguinolenta), realizou tratamento e recebeu alta. Posteriormente, retornou com queixa de edema em panturrilha esquerda, sendo diagnosticada Trombose Venosa Profunda (TVP) e utilizado heparina, que após 24h foi suspensa pelo fato da paciente ter apresentado hematoquezia intensa. Três dias após, a paciente apresentou quadro de desconforto respiratório e dor torácica, recebendo o diagnóstico de Tromboembolismo Pulmonar (TEP). Foi colocado filtro de veia cava inferior e iniciado heparinização com Marevan®, que foi suspenso seis meses depois. Atualmente, encontra-se em acompanhamento no ambulatório de Gastroenterologia do Hospital das Clínicas (HC) ­ UFPE, sem queixas, emuso de Sulfassalazina.

The authors present a case of a 42 year-old patient who developed Inespecifi c Ulcerative Rectocolitis, being asymptomatic for six years, without adequate treatment. She was interned after the appearance of symptoms of the disease in activity (fever, asthenia, bloody diarrhea). She underwent treatement and was discharged. Afterwards, she returned complaining about edema in the left calf, being diagnosed of a Deep Venous Thrombosis and using heparin that was suspended after 24 hours, because the patient developed intense hematochezia. After three days, the patient had respiratory discomfort and thoracic pain, and was diagnosed of a pulmonary thromboembolism, and was initialized a filter to the inferior vena cava and was used heparinezation with Marevan®, which was suspended six months later. Nowadays, the patient is accompanied by the Gastroenterology ambulatory of Hospital das Clinicas-Pernambuco, without complaints, using Sulfassalazin.

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