RESUMEN
OBJECTIVE: Our purpose was to compare the findings of CT pulmonary densitovolumetry and pulmonary function in patients with active acromegaly and controlled acromegaly and, secondarily, to correlate these findings. METHODS: 11 patients with active acromegaly, 18 patients with controlled acromegaly and 17 control subjects, all non-smokers, underwent quantification of lung volume using multidetector CT (Q-MDCT) and pulmonary function tests. RESULTS: Patients with active acromegaly had larger total lung mass (TLM) values than the controls and larger amounts of non-aerated compartments than the other two groups. Patients with active acromegaly also had larger amounts of poorly aerated compartments than the other two groups, a difference that was observed in both total lung volume (TLV) and TLM. TLV as measured by inspiratory Q-MDCT correlated significantly with total lung capacity, whereas TLV measured using expiratory Q-MDCT correlated significantly with functional residual capacity. CONCLUSION: Patients with active acromegaly have more lung mass and larger amounts of non-aerated and poorly aerated compartments. There is a relationship between the findings of CT pulmonary densitovolumetry and pulmonary function test parameters. ADVANCES IN KNOWLEDGE: Although the nature of our results demands further investigation, our data suggest that both CT pulmonary densitovolumetry and pulmonary function tests can be used as useful tools for patients with acromegaly by assisting in the prediction of disease activity.
Asunto(s)
Acromegalia/diagnóstico por imagen , Acromegalia/fisiopatología , Pulmón/diagnóstico por imagen , Pulmón/fisiopatología , Tomografía Computarizada Multidetector , Adulto , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pruebas de Función Respiratoria/estadística & datos numéricosRESUMEN
O conhecimento da DPOC ganhou extrema relevância na sociedade moderna, visto que essa é a quarta causa de morte nos EUA, afetando 14 milhões de pessoas. No Brasil, a DPOC é a quinta maior causa de internação de adultos no sistema público de saúde, com cerca de 200.000 internações ao ano. Achados de imagem classicamente são manifestações tardias na história natural dessa doença e nem sempre se associam a alterações funcionais. Porém, os avanços na área de TCAR tornaram-na o método de escolha para a quantificação in vivo do enfisema, sendo mais sensível que a espirometria para esse fim. Além disso, os métodos de imagem são capazes de auxiliar o diagnóstico das principais complicações associadas à DPOC, sendo uma arma fundamental para o clínico no manejo desses pacientes.Devido à alta prevalência e gravidade da doença, o diagnóstico precoce e a adequada avaliação das complicações associadas são fundamentais para o estabelecimento da terapêutica apropriada e consequente melhoria da qualidade de vida dospacientes
Knowledge of COPD has become extremely relevant in modern society because COPD is the fourth leading cause of death in the United States, affecting 14 million people. In Brazil, COPD is the fifth leading cause of hospitalization of adults within thepublic health care system, accounting for approximately 200,000 hospitalizations per year.Imaging findings are classically observed late in the natural history of COPD and do not always correlate with functional changes. However, advances in HRCT techniques have made it more sensitive than is spirometry for quantifying emphysema and therefore the method of choice for that purpose. In addition, imaging studies can facilitate the diagnosis of majorcomplications associated with COPD, making them a fundamental tool for clinicians who are involved in the management of patients with COPD.Due to the high prevalence and severity of COPD, the early diagnosis and proper evaluation of associated complications are fundamental to establishing the appropriate therapy and consequently improving patient quality of life.