1.
ACS Chem Neurosci
; 1(12): 788-95, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22778815
RESUMEN
A series of 1,5-disubstituted pyridones was identified as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor 2 (mGluR2) via high throughput screening (HTS). Subsequent SAR exploration led to the identification of several compounds with improved in vitro activity. Lead compound 8 was further profiled and found to attenuate the increase in PCP induced locomotor activity in mice.