Asunto(s)
Altitud , Enfermedad Coronaria/mortalidad , Etnicidad , Hispánicos o Latinos , Humanos , Masculino , New MexicoAsunto(s)
Neoplasias de la Mama/epidemiología , Paridad , Factores de Edad , Brasil , Femenino , Humanos , Edad Materna , EmbarazoAsunto(s)
Neoplasias de la Mama/epidemiología , Neoplasias de la Mama/etiología , Paridad , Aborto Espontáneo/epidemiología , Adolescente , Adulto , Factores de Edad , Anciano , Estatura , Peso Corporal , Brasil , Castración , Femenino , Muerte Fetal/epidemiología , Lateralidad Funcional , Humanos , Lactancia , Matrimonio , Menarquia , Menopausia , Menstruación , Persona de Mediana Edad , EmbarazoRESUMEN
An international collaborative study has been carried out to test the hypothesis that prolonged lactation protects women against cancer of the breast. While pregnancy itself seemed to confer some protection against breast cancer in all areas studied, no consistent differences in duration of lactation were found between breast cancer patients and unaffected women, once the fact that breast cancer patients have fewer pregnancies had been allowed for. Even in areas where some women had lactated for a total of 5 years or more, such women occurred proportionately no less frequently among breast cancer patients than among unaffected women. In the light of this and other recent evidence, it is unlikely that lactation has any protective effect against breast cancer in women, and other explanations must be sought for the remarkable international differences in the frequency of this disease.
Asunto(s)
Neoplasias de la Mama/prevención & control , Lactancia , Adulto , Anciano , Boston , Brasil , Neoplasias de la Mama/epidemiología , Neoplasias de la Mama/etiología , Femenino , Grecia , Humanos , Cooperación Internacional , Persona de Mediana Edad , Embarazo , Taiwán , Factores de Tiempo , Tokio , Gales , YugoslaviaRESUMEN
An international collaborative study of breast cancer and reproductive experience has been carried out in 7 areas of the world. In all areas studied, a striking relation between age at first birth and breast cancer risk was observed. It is estimated that women having their first child when aged under 18 years have only about one-third the breast cancer risk of those whose first birth is delayed until the age of 35 years or more. Births after the first, even if they occur at an early age, have no, or very little, protective effect. The reduced risk of breast cancer in women having their first child at an early age explains the previously observed inverse relationship between total parity and breast cancer risk, since women having their first birth early tend to become ultimately of high parity. The association with age at first birth requires different kinds of etiological hypotheses from those that have been invoked in the past to explain the association between breast cancer risk and reproductive experience.