RESUMEN

A new benzylated alkamide, N-(3,4-dimethoxybenzyl)-9Z-oleamide (1), along with two known ones (2 and 3) were isolated from the roots of Lepidium meyenii collected from Lijiang, Yunnan Province of China. Their structures were elucidated by extensive spectroscopic analyses and the new compound further confirmed by a one-step synthesis. All the isolated alkamides were evaluated for their cytotoxicity against five human cancer cell lines. However, no significant activities were detected at concentrations up to 40 µM.

Asunto(s)

Compuestos de Bencilo/aislamiento & purificación , Lepidium/química , Alcamidas Poliinsaturadas/aislamiento & purificación , Antineoplásicos Fitogénicos/síntesis química , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Compuestos de Bencilo/química , Compuestos de Bencilo/farmacología , Línea Celular Tumoral , China , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Espectroscopía de Resonancia Magnética , Estructura Molecular , Raíces de Plantas/química , Alcamidas Poliinsaturadas/química , Alcamidas Poliinsaturadas/farmacología