RESUMEN
The management of complex uveitis is often based around the use of oral corticosteroids. To spare the side effects of corticosteroids, second-line oral immunosuppressant drugs are used. Newer systemic immunosuppressive drugs, including biologics, and locally delivered treatments are being evaluated. This article reviews current conventional treatments, discusses their limitations and evaluates newer treatment strategies. Current theories about the pathogenesis of uveitis and potential targets for treatment are discussed in this context. We are still in search of a low-risk, where possible, locally delivered and targeted treatment for uveitis.
Asunto(s)
Descubrimiento de Drogas/tendencias , Uveítis/tratamiento farmacológico , Corticoesteroides/uso terapéutico , Animales , Descubrimiento de Drogas/métodos , Humanos , Inmunosupresores/uso terapéutico , Resultado del Tratamiento , Uveítis/fisiopatologíaRESUMEN
Talc from surgical gloves has been known to be a cause of granulomas within the surgical cavity. We report a case in which recurrent conjuntival inflammation was found to be caused by talc.
Asunto(s)
Conjuntivitis/etiología , Guantes Quirúrgicos/efectos adversos , Granuloma de Cuerpo Extraño/etiología , Complicaciones Posoperatorias/etiología , Talco/efectos adversos , Biopsia , Conjuntivitis/patología , Femenino , Granuloma de Cuerpo Extraño/patología , Humanos , Persona de Mediana Edad , Complicaciones Posoperatorias/patologíaRESUMEN
OBJECTIVE: To test the convergent validity of the Manchester pain scale when compared to the current 'gold standard' in children's pain assessment, the Oucher pain scale. METHOD: One hundred and fifty two children presenting to the emergency department had pain scale assessments using both the Manchester and Oucher pain scales. The order of presentation of the scales was randomised. The degree of convergence between the scales was assessed using Spearman's rank correlation as well as Bland and Altman plots. RESULTS: One hundred and thirteen children used numerical scales; the correlation coefficient for these was 0.802. Thirty nine children used pictorial scales; the correlation coefficient was 0.820. CONCLUSION: There is strong convergent validity between the scales as demonstrated by a high degree of correlation between the numerical and pictorial scores generated by the Manchester and Oucher pain scales. The Manchester pain scale can be used to assess pain in children presenting to emergency departments.
Asunto(s)
Enfermería de Urgencia/métodos , Dimensión del Dolor/instrumentación , Dimensión del Dolor/métodos , Dolor/clasificación , Dolor/diagnóstico , Enfermería Pediátrica/métodos , Adolescente , Niño , Preescolar , Femenino , Humanos , Masculino , Dimensión del Dolor/normas , Reproducibilidad de los Resultados , Sensibilidad y Especificidad , Estadística como AsuntoRESUMEN
A short cut review was carried out to establish which of the Oucher or CHEOPS pain assessments were best for assessing pain in children. Altogether 12 papers were found using the reported search, of which three presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. A clinical bottom line is stated.