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Syphilis is a chronic bacterial sexually transmitted infectious disease caused by Treponema pallidum. Different age groups are affected by heterogeneous clinical forms of the disease. We report a case of atypical secondary syphilis in an elderly patient with diffuse annular erythematous lesions on the chest, back, upper and lower limbs diagnosed by histopathological, immunohistochemical and serological tests.

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Embora várias técnicas tenham sido descritas para a reconstrução do lábio superior, a reconstrução funcional dos defeitos totais do lábio superior permanece um desafio. Neste caso, realizou-se a exérese de um carcinoma espinocelular de tamanho significante, em região labial superior, por meio da técnica de duplo avanço, com resultados funcional e estético positivos.

Although several techniques have been described for upper lip reconstruction, functional reconstruction of total upper lip defects remains a challenge. We report a case of a significant size squamous cell carcinoma excised in the upper lip region using the double-advancement technique, with positive functional and aesthetic results

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O carcinoma epidermoide (carcinoma escamocelular, carcinoma de células escamosas ou CEC) representa o segundo tipo de neoplasia cutânea mais comum. O CEC origina-se da proliferação atípica das células da camada espinhosa da epiderme e é mais frequente em indivíduos do sexo masculino, maiores de 50 anos, de fototipo baixo e com história de exposição solar. Descrevemos o caso de um homem de 61 anos, previamente hígido, apresentando lesão de crescimento rápido e exuberante na face, cujo anatomopatológico e imuno-histoquímica comprovaram tratar-se de CEC moderadamente diferenciado.

Squamous cell carcinoma (SCC) represents the second most common type of skin cancer. SCC originates from the atypical proliferation of the cells of the epidermis's spinous layer and is more frequent in men over 50 years of age, with a low skin phototype and history of sun exposure. We describe the case of a 61-yearold man, previously healthy, with a lesion presenting fast and exuberant growth on the face. The anatomopathological and immunohistochemical exams confirmed the diagnosis of moderately differentiated SCC.

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O xantogranuloma múltiplo do adulto é uma apresentação mais rara e tardia do xantogranuloma juvenil, uma histiocitose de células não Langerhans. No adulto, normalmente, é uma lesão única, sendo a manifestação por múltiplas lesões infrequente e pouco descrita na literatura. Relatamos um caso de xantogranuloma múltiplo do adulto, com falha terapêutica à isotretinoína e ótima resposta ao tratamento com laser CO2 no modo cirúrgico

Multiple adult xanthogranuloma is a rare and late variant of Juvenile xanthogranuloma, a non-Langerhans cell histiocytosis. It usually corresponds to a single lesion in adults, and the manifestation of multiples lesions is uncommon. We report a case of multiple adult xanthogranuloma, with Isotretinoin therapy failure and optimal response to CO2 Laser treatment in the surgical mode.

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We report a case of phaeohyphomycosis that affected the leg of a 45-year-old Brazilian man, car mechanic and renal transplanted. The direct mycological examination evidenced dematiaceous septated hyphae. The pathogenic fungal species was identified as Exophiala xenobiotica. Antifungal activity in vitro revealed terbinafine as the best antifungal. For treatment, it was chosen surgical excision of the entire lesion and used systemic itraconazole. Phaeohyphomycosis caused by Exophiala xenobiotica is extremely rare and is closely related to transplant patients.

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Langerhans cell histiocytosis is a rare clonal proliferative disease, characterized by the infiltration of one or multiple organs by histiocytes. Due to the diversity of signs and symptoms, the diagnosis of this disease is often late. The estimated incidence in adults is one to two cases per million, but the disease is probably underdiagnosed in this population. This report presents a case of disseminated Langerhans cell histiocytosis. The authors highlight the most characteristic aspects of this rare and heterogeneous disease, which usually presents as a challenging clinical diagnosis.

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Abstract Langerhans cell histiocytosis is a rare clonal proliferative disease, characterized by the infiltration of one or multiple organs by histiocytes. Due to the diversity of signs and symptoms, the diagnosis of this disease is often late. The estimated incidence in adults is one to two cases per million, but the disease is probably underdiagnosed in this population. This report presents a case of disseminated Langerhans cell histiocytosis. The authors highlight the most characteristic aspects of this rare and heterogeneous disease, which usually presents as a challenging clinical diagnosis.

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Agminated nevus is a cluster group of melanocytic nevi confined to a localized area of the body. There are many pigmented lesions described in the literature as agminated, such as blue nevi, multiple lentigines and Spitz nevi, but only a few cases of congenital agminated melanocytic nevi have been described. We report a case of a male child who presented with congenital agminated nevi, emphasizing the importance of physical examination, dermoscopy, histopathological evaluation, differential diagnosis and follow up to rule out the possibility of dysplastic or malignant changes.

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Agminated nevus is a cluster group of melanocytic nevi confined to a localized area of the body. There are many pigmented lesions described in the literature as agminated, such as blue nevi, multiple lentigines and Spitz nevi, but only a few cases of congenital agminated melanocytic nevi have been described. We report a case of a male child who presented with congenital agminated nevi, emphasizing the importance of physical examination, dermoscopy, histopathological evaluation, differential diagnosis and follow up to rule out the possibility of dysplastic or malignant changes.

Nevo agminado é um conjunto de lesões melanocíticas confinadas a uma área do corpo. Existem muitas lesões descritas na literatura como agminada s, como nevos azuis, lentigos múltiplos, nevo de Spitz, mas existem poucos casos de nevos melanocíticos agminados congênitos descritos. Relatamos o caso de um paciente do sexo masculino que se apresentou com um nevo agminado congênito, enfatizando a importância do exame físico, dermatoscopia, avaliação histológica, diagnóstico diferencial e seguimento para descartar a possibilidade de alterações displásicas ou malignas.

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Lichen nitidus is a rare dermatosis, characterized by round, skin-colored papules whose size varies between 1-2 mm and are generally asymptomatic. It does not have predilection for gender or race, affecting mainly children and young adults. Its clinical course is unpredictable, but most cases tend to spontaneously regress years after the onset of the disease. Lesions are often localized, but rare reports of disseminated disease exist.

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Líquen nítido é uma dermatose rara, caracterizada por pápulas arredondadas normocrômicas de diâmetro, variando entre 1-2 mm, e geralmente assintomáticas. Sem predileção por sexo ou raça, acomete, principalmente, crianças e adultos jovens, na maioria dos casos, possuindo curso clínico imprevisível e tendendo à regressão espontânea, anos após o início da doença. As lesões são em geral localizadas, mas raros relatos da doença cursando com lesões disseminadas existem.

Lichen nitidus is a rare dermatosis, characterized by round, skin-colored papules whose size varies between 1-2 mm and are generally asymptomatic. It does not have predilection for gender or race, affecting mainly children and young adults. Its clinical course is unpredictable, but most cases tend to spontaneously regress years after the onset of the disease. Lesions are often localized, but rare reports of disseminated disease exist.

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