Asunto(s)
Reacciones Antígeno-Anticuerpo/efectos de los fármacos , Vacunas Tifoides-Paratifoides/farmacología , Adolescente , Adulto , Aglutininas/análisis , Ensayos Clínicos como Asunto , Humanos , Inmunidad Materno-Adquirida/efectos de los fármacos , Inmunización , Placebos , Factores de Tiempo , Vacunas Tifoides-Paratifoides/efectos adversosRESUMEN
A comparative study of the reactogenicity and immunologial activity of a new chemical sorbed typhoid monovaccine II, reference-vaccine (chemical sorbed monovaccine from tryptic antigens) and placebo-sorbent (hydroxy aluminium gel) was made under conditions of strictly gested monovaccine II, an equal capacity to induce formation of O- and Vi-antibodies, and also an accumulation of H-antibodies not induced by refrence-vaccine.
Asunto(s)
Fiebre Tifoidea/prevención & control , Vacunas Tifoides-Paratifoides , Vacunación , Adolescente , Adulto , Anticuerpos Antibacterianos , Formación de Anticuerpos , Ensayos Clínicos como Asunto , Flagelos/inmunología , Humanos , Vacunas Tifoides-Paratifoides/efectos adversosRESUMEN
The authors present the results of study of physico-chemical properties of the chemical sorbed monovaccines from the antigens of the causative agents of typhoid fever, paratyphoid A and B and Sonne and Flexner dysentery obtained by various methods; the results of investigation of their reactogenic properties and immunological activity of limited groups of volunteers also given. The vaccines from the antigens obtained by sparing methods were less reactogenic than the rest experimental and control vaccines obtained from the tryptic antigens. The majority of the experimental vaccines caused a significant increase of the specific antibody titres in the sera of the vaccinated persons: typhoid vaccines--of the O-, VI- and H-antibodies, paratyphoid B vaccines--of the O- and H-antibodies; the control vaccines from the tryptic antigens failed to induce the H-antibody synteisis in the vaccinated persons. Experimental dysentery monovaccines induced a greater increase in the antibody titres than the control vaccines.
Asunto(s)
Formación de Anticuerpos , Vacunas Bacterianas , Salmonella paratyphi A/inmunología , Salmonella typhi/inmunología , Shigella sonnei/inmunología , Vacunas Tifoides-Paratifoides , Anticuerpos Antibacterianos/análisis , Estudios de Evaluación como Asunto , Humanos , Inmunoquímica , Shigella flexneri/inmunologíaRESUMEN
As a result of comparative study of the immunological properties and antigenic activity of thyphoid, paratyphoid A and B and Sonne and Flexner dysentery antigenic preparations obtained by various methods there was revealed a decreased toxicity of the experimental preparations of the Tashkent and Leningrad Institute of Vaccines and Sera (in comparison with the tryptic antigens) and a considerable advantages of the experimental thyphoid and paratyphoid antigenic preparations by their capacity to induce the H-antibody formation in the presence of the O-antigenic activity. The preparations of the Moscow Institute of Vaccines and Sera had increased toxicity. The detected advantages of the experimental antigenic preparations of the Tashkent and Leningrad Institute of Vaccines and Sera permitted to recommend the method used in their making to obtain new chemical vaccines against the intestinal infections.