Asunto(s)
Síndrome Antifosfolípido/diagnóstico por imagen , Pielonefritis/diagnóstico por imagen , Obstrucción de la Arteria Renal/diagnóstico por imagen , Trombosis/diagnóstico por imagen , Adulto , Síndrome Antifosfolípido/etiología , Diagnóstico Diferencial , Femenino , Humanos , Pielonefritis/complicaciones , Obstrucción de la Arteria Renal/etiología , Trombosis/etiología , UltrasonografíaRESUMEN
Clinical effects and safety of doxazosine + finasteride combination were studied in patients with obstructive and irritative symptoms due to prostatic adenoma (PA). Lower urinary tract symptoms according to IPSS, size of the prostatic gland, Qmax and Qmid, bladder capacity, residual urine volume, blood pressure, PSA level, sexual function, side effects were assessed before and after combined use of the drugs in 30 patients aged 58 to 83 years (mean age 70.5 years). A significant regression of both obstructive and irritative symptoms by IPSS occurred after the treatment. Quality of life has improved. Combined treatment of PA patients has improved quality of life, urination parameters, reduced volume of residual urine. Good tolerance of the treatment was observed. Combined therapy with doxazosine and finasteride can be recommended as a basic scheme of treatment for patients with risk of PA progression.
Asunto(s)
Antagonistas Adrenérgicos alfa/administración & dosificación , Doxazosina/administración & dosificación , Inhibidores Enzimáticos/administración & dosificación , Finasterida/administración & dosificación , Hiperplasia Prostática/tratamiento farmacológico , Antagonistas Adrenérgicos alfa/efectos adversos , Anciano , Anciano de 80 o más Años , Doxazosina/efectos adversos , Quimioterapia Combinada , Inhibidores Enzimáticos/efectos adversos , Femenino , Finasterida/efectos adversos , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Hiperplasia Prostática/fisiopatología , Hiperplasia Prostática/orina , Calidad de Vida , Vejiga Urinaria/metabolismo , Vejiga Urinaria/fisiopatología , Micción/efectos de los fármacosRESUMEN
Rehabilitation therapy was performed in 5 groups (n=122) of patients operated for prostatic adenoma (TUR of the prostate, transvesical prostatectomy) and having postoperative marked irritative miction disorders. Group 1 received antibacterial therapy (AT); group 2-- AT+alpha-adrenoblockers; group 3-- AT+transrectal laser and magnetic physiotherapy; group 4-- AT+alpha-adrenoblockers+transrectal laser and magnetic physiotherapy; group 5-- AT+prostatotropic phytotherapy (gentos). The worst result was achieved in group 1, the best one--in groups 3 and 4. Thus, adjuvant physiotherapy inclusion in the complex of postoperative rehabilitation of patients operated for prostatic adenoma is justified as it improves treatment efficacy.
Asunto(s)
Hiperplasia Prostática/rehabilitación , Incontinencia Urinaria/terapia , Anciano , Anciano de 80 o más Años , Terapia Combinada/métodos , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Próstata/cirugía , Prostatectomía , Hiperplasia Prostática/complicaciones , Hiperplasia Prostática/cirugía , Resultado del Tratamiento , Incontinencia Urinaria/etiologíaRESUMEN
The study was made in 2005-2006 of efficacy and safety of combined use of doxasosine and finasteride in patients (n = 50, age 53-83) with symptoms of lower urinary tract dysfunction (LUTD) caused by prostatic adenoma. LUTD severity by IPSS, size of the prostate, maximal and mean urinary flow velocity, functional capacity of the urinary bladder, residual urine, blood pressure, a PSA level, sexual function, were assessed at baseline and after the treatment. Side effects were also registered. Combined treatment with doxasosine plus finasteride significantly lowered both obstructive and irritative LUTD symptoms by IPSS, quality of life improved from 3.4 to 2.3 scores (p < 0.01), maximal urinary flow and mean urinary flow velocity increased from 10.2 to 11.6 ml/s and from 5.4 to 6.1 ml/s, respectively, residual urine reduced from 35.2 to 7.7 ml (p < 0.01). The size of the prostate diminished from 55.8 to 46 cm(3) (p < 0.01). PSA decreased from 2.8 to 1.4 ng/ml. Erectile function did not worsen. Thus, the proposed scheme of combined treatment improves quality of life, voiding; lowers residual urine; is well tolerated; can be recommended as a basic scheme of treatment in patients with a risk of prostatic adenoma progression.
Asunto(s)
Antagonistas Adrenérgicos alfa/uso terapéutico , Doxazosina/uso terapéutico , Inhibidores Enzimáticos/uso terapéutico , Finasterida/uso terapéutico , Hiperplasia Prostática/tratamiento farmacológico , Urodinámica/efectos de los fármacos , Inhibidores de 5-alfa-Reductasa , Antagonistas Adrenérgicos alfa/administración & dosificación , Antagonistas Adrenérgicos alfa/efectos adversos , Adulto , Anciano , Doxazosina/administración & dosificación , Doxazosina/efectos adversos , Quimioterapia Combinada , Inhibidores Enzimáticos/administración & dosificación , Inhibidores Enzimáticos/efectos adversos , Finasterida/administración & dosificación , Finasterida/efectos adversos , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Hiperplasia Prostática/complicaciones , Hiperplasia Prostática/fisiopatología , Calidad de Vida , Disfunciones Sexuales Fisiológicas/etiología , Disfunciones Sexuales Fisiológicas/prevención & control , Resultado del TratamientoRESUMEN
The results of operative and rehabilitative treatment of benign prostatic hyperplasia (BPH) was analysed for 69 BPH patients with postoperative irritative disorders of voiding. The patients were divided into four groups by rehabilitative therapy: group 1 received antibacterial therapy; group 2--antibacterial therapy+alpha-adrenoblockers; group 3--antibacterial therapy+transrectal laser and magnetic physiotherapy; group 4--antibacterial therapy+alpha-adrenoblockers+transrectal laser and magnetic physiotherapy. The worst result was obtained in group 1, the best one in groups 3 and 4 (the response was compatible). Thus, the addition of physiotherapy to the complex of postoperative rehabilitation of patients operated for BPH is justified and provides treatment improvement.
Asunto(s)
Complicaciones Posoperatorias/terapia , Hiperplasia Prostática/rehabilitación , Trastornos Urinarios/terapia , Anciano , Terapia Combinada , Humanos , Terapia por Láser , Magnetismo/instrumentación , Magnetismo/uso terapéutico , Masculino , Persona de Mediana Edad , Cuidados Posoperatorios/instrumentación , Periodo Posoperatorio , Hiperplasia Prostática/cirugíaRESUMEN
Content of glycosaminoglycans was increased in pancreas of rats with acute pancreatitis. With development of the disease not only content of glycosaminoglycans but heterogeneity of their molecules were increased. This suggests that carbohydrate chains of glycosaminoglycans were degraded; the rate of degradation correlated with severity of pancreatitis.
Asunto(s)
Glicosaminoglicanos/metabolismo , Páncreas/metabolismo , Pancreatitis/metabolismo , Enfermedad Aguda , Animales , Cromatografía DEAE-Celulosa , Masculino , Ratas , Ratas EndogámicasRESUMEN
Extensive data on clinical and experimental pathology of pancreatic function are reviewed. In literature there is much controversy on the presence of hyperenzymatic secretion on the mechanism of hypersecretion and therapeutic policy for pancreatitis with hypersecretion. Fifty patients with chronic pancreatitis were evaluated functionally. Experimental study of progressing pancreatitis showed enhanced protein biosynthesis in the initial disease. Protein spectra were shifted. It is stated that hypersecretion can be either primary or secondary depending on the cause of pancreatic inflammation which is thought to initiate pancreatic hypersecretion as such.