RESUMEN
Proportions and total numbers of thymus-derived (T) and bone marrow-derived (B) peripheral blood lymphocytes were studied in 53 patients with acute rheumatic fever, diagnosed on the basis of modifified Jones criteria. An elevation in both proportions and absolute numbers of cells bearing surface Ig was found in most patients, particularly during the first 7 days after onset. Conversely, T-cell proportions and numbers were often found to be depressed early in the acue phases of rheumatic fever. Proportions of cells bearing surface Ig did not correlate with another B-cell marker, the aggregated gamma globulin receptor, suggesting that such cells bearing surface Ig were not all B lymphocytes. Incuvation for 20 h at 37 per cent C of cells showing high proportions of surface Ig-bearing surface Ig in both normal and rheumatic fever subjects, although there was no appreciable increment in proportions of lymphocytes expressing T-cell markers. Patients with initial attacks showed higher percentages and total numbers of Ig-bearing lymphocytes (P smaller than 0.01) than did those with rneumatic fever recurrences. Elevations in numbers and proportions of peripheral blood lymphocytes bearing Ig appeared to correlate with the relative acute nature of the rheumatic fever attack.
Asunto(s)
Linfocitos B , Fiebre Reumática/sangre , Linfocitos T , Enfermedad Aguda , Adolescente , Adulto , Animales , Linfocitos B/inmunología , Niño , Preescolar , Egipto , Eritrocitos/inmunología , Femenino , Técnica del Anticuerpo Fluorescente , Humanos , Reacción de Inmunoadherencia , Inmunoglobulina A/análisis , Inmunoglobulina G/análisis , Inmunoglobulina M/análisis , Recuento de Leucocitos , Masculino , Ovinos/inmunologíaAsunto(s)
Arritmias Cardíacas/etiología , Sulfato de Bario , Enema/efectos adversos , Adolescente , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Monitoreo FisiológicoAsunto(s)
Electrocardiografía , Defectos del Tabique Interventricular/cirugía , Corazón/fisiopatología , Hemodinámica , Hipertensión Pulmonar/cirugía , Adolescente , Adulto , Presión Sanguínea , Cateterismo Cardíaco , Niño , Preescolar , Femenino , Defectos del Tabique Interventricular/fisiopatología , Humanos , Hipertensión Pulmonar/fisiopatología , Lactante , Rendimiento Pulmonar , Masculino , Resistencia VascularRESUMEN
Eight patients with mild to moderate valvular pulmonary stenosis underwent serial physiological studies before surgical intervention. Average pulmonary valve area at the initial study was 0.59 cm.2 and at the second study (average 7.8 years later) was 1.09 cm.2, resulting in an average increase of 0.49 cm.2 (p greater than 0.05). In normal subjects during early years the pulmonary valve area increases linearly with age and with increasing body surface area. Though patients with valvular pulmonary stenosis have smaller valve orifices, they also show an increase in valve size with increasing age and with increasing body growth. The greatest increase in valve area was observed in 4 patients (all under age 6) in whom body surface area increased more than 70 per cent.