RESUMEN

Inflammatory cytokines have an important role in the pathogenesis of myocarditis, but still little is known about the importance of interferon gamma (IFNg) in this disease. The aim of the study was to evaluate the prognostic value of the initial transcriptional activity of IFNg and two subunits of its receptor as measured with the use of QRT-PCR and SYBRGreen chemistry in the group of 63 patients with clinically confirmed myocarditis who were treated with statin or immunosupressive therapy. The initial values of IFNg and the ratio of IFNgRb/IFNgRa were statistically different in the analyzed group of patients. The prognostic value of IFNg and IFNgRb/IFNgRa was determined by logistic regression analysis.

Asunto(s)

Interferón gamma/genética , Miocarditis/fisiopatología , Receptores de Interferón/genética , Benzotiazoles , Biomarcadores/metabolismo , Diaminas , Humanos , Inhibidores de Hidroximetilglutaril-CoA Reductasas/uso terapéutico , Inmunosupresores/uso terapéutico , Interferón gamma/metabolismo , Modelos Logísticos , Miocarditis/diagnóstico , Miocarditis/tratamiento farmacológico , Compuestos Orgánicos/metabolismo , Pronóstico , Subunidades de Proteína/genética , Subunidades de Proteína/metabolismo , Quinolinas , Receptores de Interferón/metabolismo , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Transcripción Genética , Receptor de Interferón gamma