RESUMEN
Congenital urinary tract obstruction is one of the most frequent malformations in fetuses or neonates, which usually causes profound impairment of renal function including reductions in both glomerular filtration rate (GFR) and tubular handling of water and solutes. Although obstruction can be released by surgical operation, the child will suffer from diuresis for sometime. It has been reported that erythropoietin (EPO) could prevent the down-regulation of aquaporin-2 (AQP2) and urinary-concentrating defects induced by renal ischemia/reperfusion (I/R) injury. However, whether EPO could promote the recovery of renal function and AQP2 expression after releasing of ureteral obstruction has not been reported yet. The purposes of the present study were to investigate the effects of EPO on renal function and AQP2 expression after release of bilateral ureteral obstruction (BUO-R) in rats. The results showed that EPO could promote interleukin (IL) 10 (IL-10) expression; inhibit tumor necrosis factor-α (TNF-α), IL-6, and inducible nitric oxide synthase (iNOS) expressions; reduce the fractional excretion of sodium (FENa) and plasma creatinine (CREA) and urea; and promote the recovery of water and salt handling and AQP2 expression in BUO-R rats, especially in the high dose of EPO-treated group rats. In conclusion, EPO could promote the recovery of renal function and AQP2 expression in BUO-R rats, which may partially associate with its anti-inflammation effect.
Asunto(s)
Modelos Animales de Enfermedad , Eritropoyetina/farmacología , Riñón/efectos de los fármacos , Obstrucción Ureteral/fisiopatología , Animales , Acuaporina 2/genética , Acuaporina 2/metabolismo , Tasa de Filtración Glomerular/efectos de los fármacos , Humanos , Riñón/metabolismo , Riñón/fisiopatología , Masculino , Sustancias Protectoras/farmacología , Ratas Sprague-Dawley , Daño por Reperfusión/metabolismo , Daño por Reperfusión/fisiopatología , Obstrucción Ureteral/genética , Obstrucción Ureteral/metabolismoRESUMEN
A variety of conditions exists in adults and children in which functional or anatomical urinary tract obstructions cause bladder fibrosis, which reduces the bladder's ability to store and empty urine. Current surgical procedures include removal of the obstructions to facilitate bladder emptying or prompt prenatal or postnatal spinal closure to prevent further neurogenic damage. Bladder fibrosis may occur, and it can get worse if a flow hindrance persists or deteriorates. Anti-fibrotic therapeutic strategies that target a variety of factors have been developed in animal models, but currently there are no anti-fibrotic therapies available for clinical use. This review examines the pathogenesis of bladder fibrosis that is caused by congenital obstructions of the lower urinary tract, and it focuses on the principal signalling factors and potential treatment modalities.
Asunto(s)
Obstrucción Ureteral/complicaciones , Obstrucción Ureteral/terapia , Obstrucción Uretral/complicaciones , Obstrucción Uretral/terapia , Enfermedades de la Vejiga Urinaria/etiología , Vejiga Urinaria/patología , Niño , Fibrosis , HumanosRESUMEN
AIMS: To understand the function development of bladder and its evaluation in neonates and infants less than 2 years old. METHODS: Literature on neonatal and infant bladder function development and urodynamic evaluation were collected and reviewed. RESULTS: Normal range of bladder volume, pressure during voiding and other parameters in neonates and infants less than 2 years old is far from set up, making interpretation of UDS findings difficult. This review provides insight into the bladder development process and problems of the lower urinary tract in this age group with special emphasis on the urodynamic evaluation. CONCLUSIONS: Further animal and human studies will increase our understanding of bladder development leading toward mature function. UDS are still important in providing information for early bladder dysfunction in newborns and infants.
Asunto(s)
Vejiga Urinaria/crecimiento & desarrollo , Vejiga Urinaria/fisiología , Urodinámica/fisiología , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Valores de Referencia , Caracteres Sexuales , Uretra/inervación , Vejiga Urinaria/embriología , Micción/fisiologíaRESUMEN
AIM: The neonatal period is critical in bladder development, encompassing the transition from foetal bladder contractions to voluntary infant urination. The aim of this study was to investigate different voiding parameters between male and female newborn infants. METHODS: We studied 102 healthy, single birth newborn infants - 54 preterm and 48 full-term - without lower urinary tract diseases, hospitalised in the neonatal intensive care unit from March 2011 to March 2012. Free voiding was observed from 9 a.m. to 9 p.m., and the free voiding parameters and fluid intake were recorded and compared between male and female newborn infants using the Student's t-test and chi-square test. RESULTS: Male preterm newborns demonstrated larger mean postvoid residual volumes and lower bladder emptying rates than female preterm newborns (p < 0.05), and male full-term newborns had lower bladder emptying rates than female full-term newborns (p < 0.05). The bladder emptying rates of newborns defecating simultaneously with voiding were not statistically different between males and females of the same gestational age (p > 0.05). CONCLUSION: Male newborns were more likely to have larger postvoid residual volumes than females, and defecating simultaneously with voiding may promote bladder emptying in male newborns.