RESUMEN
We analyse our results in the treatment of the tumors of the parotid gland, diagnosticated from 1981 till end of 2004. We saw 132 patients with tumors of the parotid, being 41 of them malignant. The surgical technique more used was the total parotidectomy with conservation of the facial nerve. The global survival obtained in the malignant tumors was 60% after five years. Surgery is the treatment of election in the tumors of epitelial origin of the parotid gland. The derived of the lymphoid tissue must be treated by other ways and are inheritance of the hematologic oncology.
Asunto(s)
Adenolinfoma/cirugía , Adenoma Pleomórfico/cirugía , Carcinoma Mucoepidermoide/cirugía , Carcinoma de Células Escamosas/cirugía , Neoplasias de la Parótida/cirugía , Adenolinfoma/patología , Adenoma Pleomórfico/patología , Anciano , Carcinoma Mucoepidermoide/patología , Carcinoma de Células Escamosas/patología , Terapia Combinada , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Glándula Parótida/patología , Glándula Parótida/cirugía , Neoplasias de la Parótida/tratamiento farmacológico , Neoplasias de la Parótida/mortalidad , Neoplasias de la Parótida/patología , Neoplasias de la Parótida/radioterapia , Complicaciones Posoperatorias , Estudios Retrospectivos , Factores de Tiempo , Resultado del TratamientoRESUMEN
Analizamos nuestros resultados en el tratamiento de los tumores de la glándula parótida diagnosticados desde 1981 hasta finales del 2004. Vimos 132 pacientes con tumores de la parótida, siendo 41 de ellos malignos. La técnica quirúrgica más usada fue la parotidectomía total con conservación del nervio facial. La supervivencia global que obtuvimos en los tumores malignos fue del 60% a los cinco años. La cirugía es el tratametno de elección de los tumores de estirpe epitelial de la glándula parótida. Los derivados del tejido linfoide deben tratarse por otros medios y son patrimonio de la oncología hematológica
We analyse our results in the treatment of the tumors of the parotid gland, diagnosticated from 1981 till end of 2004. We saw 132 patients with tumors of the parotid, being 41 of them malignant. The surgical technique more used was the total parotidectomy with conservation of the facial nerve. The global survival obtained in the malignant tumors was 60% after five years. Surgery is the treatment of election in the tumors of epitelial origin of the parotid gland. The derived of the lymphoid tissue must be treated by other ways and are inheritance of the hematologic oncology
Asunto(s)
Humanos , Masculino , Femenino , Persona de Mediana Edad , Neoplasias de la Parótida/diagnóstico , Neoplasias de la Parótida/tratamiento farmacológico , Neoplasias de la Parótida/cirugía , Estadificación de Neoplasias/métodos , Estudios de Seguimiento , Resultado del Tratamiento , Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/cirugía , Terapia Combinada/métodos , Neoplasias de la Parótida/mortalidad , Neoplasias de la Parótida/radioterapia , Factores de Tiempo , Estudios Retrospectivos , Complicaciones Posoperatorias , Adenolinfoma/patología , Liposarcoma/patología , Tumor Mucoepidermoide/complicaciones , Tumor Mucoepidermoide/patología , Tumor Mucoepidermoide/cirugíaRESUMEN
P53 protein detects damages in DNA, stopping the cellular cycle to repair it and stimulates "apoptosis" or programmed death cell when it cannot do it. We present an immunohistochemistry study of 58 squamous cell carcinomas of larynx operated between 1991 and 1996 and in which we detected the overexpression of P53 in 31 cases (53.44%). We did not find a statistic relationship between survival and the detection of P53 protein using Log Rank statistic analysis; the survival media for the wild-type protein cases was 64 months (very similar to native cases).
Asunto(s)
Carcinoma de Células Escamosas/metabolismo , Neoplasias Laríngeas/metabolismo , Proteína p53 Supresora de Tumor/metabolismo , Carcinoma de Células Escamosas/mortalidad , Carcinoma de Células Escamosas/patología , Técnicas de Cultivo , Humanos , Inmunohistoquímica , Neoplasias Laríngeas/mortalidad , Neoplasias Laríngeas/patología , Tasa de SupervivenciaRESUMEN
La proteína P53 actúa detectando el ADN celular dañado, deteniendo el ciclo celular para repararlo y estimulando la "apoptosis" o muerte celular programada cuando no lo consigue. Realizamos un estudio mediante inmunohistoquímica de 58 carcinomas epidermoides de laringe intervenidos de su patología entre 1991 y 1996 siendo la proteína mutada positiva en 31 casos (53,44 por ciento). No encontramos una relación estadísticamente significativa mediante el análisis estadístico de Log Rank entre la supervivencia y la positividad para la proteína P53, siendo la supervivencia media para los casos negativos para la proteína de 64 meses de media, muy similar a los casos que presentan la proteína mutada (AU)
P53 protein detects damages in DNA, stopping the cellular cycle to repair it and stimulates «apoptosis» or programmed death cell when it cannot do it. We present an immunohistochemistry study of 58 squamous cell carcinomas of larynx operated between 1991 and 1996 and in which we detected the over expression of P53 in 31 cases (53.44%). We did not find a statistic relationship between survival and the detection of P53 protein using Log Rank statistic analysis; the survival media for the wild-type protein cases was 64 months (very similar to native cases) (AU)
Asunto(s)
Humanos , Carcinoma de Células Escamosas/metabolismo , Inmunohistoquímica , Proteína p53 Supresora de Tumor/metabolismo , Neoplasias Laríngeas/metabolismo , Tasa de Supervivencia , Técnicas de CultivoRESUMEN
In this study was considered 58 patients diagnosed of squamous cell carcinoma of larynx and operated between 1991 and 1996 at the Ear Nose and Throat Service of the University Hospital Complex of Santiago de Compostela. They are all men but one female and the biggest percentage were T2 (39.7%) and T3 (37.9%) tumours. The macroscopic characters such as the average diameter of the pieces was 6.91 cm and 2.66 cm of the tumour. The most usual tumoral shape encounter was exofitic and ulcerous. And between the microscopic characters we valued the histologic grade of differentiation and the most usual were the well (44.8%) and moderated (41.4%) differentiated. The average of mitosis was 20.6 and 31 tumours presented necrosis.
Asunto(s)
Carcinoma de Células Escamosas/patología , Neoplasias Laríngeas/patología , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma de Células Escamosas/cirugía , Femenino , Humanos , Neoplasias Laríngeas/cirugía , Masculino , Persona de Mediana EdadRESUMEN
Previous studies on cell proliferation in salivary gland tumors have shown the utility of immunostain with MIB1 in the differential diagnosis and prognosis of these neoplasms. We have carried out a study of 39 salivary gland tumors (17 benign), from different histological lineages. The immunocytochemical method used was the streptavidin--biotin--peroxidase complex which used the MIB1 monoclonal antibody. Benign tumors showed a low cell proliferation rates, below 5% with an overall average of 1.9%. The malignant tumors presented higher rates, with a middle value of 17.85%. Epidermoid carcinomas had the higher cell proliferation rates, with an average of 43%. In adenoid cystic carcinomas, we have observed that proliferation was greater at the peripheral level of tumor nests and cell surrounding the cystic structures. Neoplasms of low grade of malignancy presented lower cell proliferation rates. The MIB1 immunostain allowed to reach a differential diagnosis between pleomorphic adenoma and adenoid cystic carcinoma, specially in those cases in which there could be any doubt.
Asunto(s)
Neoplasias de las Glándulas Salivales/patología , División Celular , HumanosRESUMEN
Los estudios realizados sobre proliferación celular en los tumores de glándulas salivales han demostrado la utilidad de la inmunotinción con MIB1 en el diagnóstico diferencial y pronóstico de estas neoplasias. Se realizó un estudio sobre 39 tumores de glándulas salivales (17 benignos), de diferentes estirpes histológicas. La técnica inmunohistoquímica empleada fue el complejo estreptavidina-biotina-peroxidasa utilizando el anticuerpo monoclonal MIB1. Los tumores benignos presentaron índices de proliferación celular bajos, menores del 5 por ciento, con una media global del 1,9 por ciento. Los tumores malignos presentaron índices superiores, con un valor medio de 17,85 por ciento. Los carcinomas epide moides presentaron los índices de proliferación celular más elevados, con una media del 43 por ciento. En los carcinomas adenoide quísticos se observó mayor proliferación a nivel de la periferia de los nidos tumorales y de las células que rodean las estructuras quísticas. Las neoplasias consideradas como de bajo grado de malignidad presentaron índices de proliferación celular más bajos. La inmunotinción con MIB1 nos permitió realizar el diagnóstico diferencial entre el adenoma pleomorfo y el carcinoma adenoide quístico, en aquellos casos en que pudiera existir duda (AU)
Previous studies on cell proliferation in salivary gland tumors have shown the utility of immunostain with MIB1 in the differential diagnosis and prognosis of these neoplasms. We have carried out a study of 39 salivary gland tumors (17 benign), from different histological lineages. The immunocytochemical method used was the streptavidin--biotin--peroxidase complex which used the MIB1 monoclonal antibody. Benign tumors showed a low cell proliferation rates, below 5% with an overall average of 1.9%. The malignant tumors presented higher rates, with a middle value of 17.85%. Epidermoid carcinomas had the higher cell proliferation rates, with an average of 43%. In adenoid cystic carcinomas, we have observed that proliferation was greater at the peripheral level of tumor nests and cell surrounding the cystic structures. Neoplasms of low grade of malignancy presented lower cell proliferation rates. The MIB1 immunostain allowed to reach a differential diagnosis between pleomorphic adenoma and adenoid cystic carcinoma, specially in those cases in which there could be any doubt (AU)
Asunto(s)
Humanos , Neoplasias de las Glándulas Salivales/patología , División CelularRESUMEN
Cell proliferation index is one of the most important factors in assessment of growth and progression of tumours. At present, the most suitable method of determining cell proliferation is by means of immunohistochemical techniques which use the monoclonal anti-body MIB-1 which reacts against Ki-67, a protein released only in the proliferation phases of the cell cycle. In this study, 44 patients diagnosed with squamous cell carcinoma of the larynx were analysed retrospectively and different macroscopic and microscopic parameters were assessed, such as MIB-1 in relation to the current status of the patient. A statistically significant relationship was found between the cell proliferation index, the histological grade of differentiation and the clinical evolution of the illness.
Asunto(s)
Carcinoma de Células Escamosas/mortalidad , Carcinoma de Células Escamosas/patología , Neoplasias Laríngeas/mortalidad , Neoplasias Laríngeas/patología , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma de Células Escamosas/metabolismo , División Celular , Femenino , Humanos , Inmunohistoquímica , Neoplasias Laríngeas/metabolismo , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Tasa de SupervivenciaRESUMEN
El granuloma eosinófilo forma parte del grupo de enfermedades de etiología desconocida denominadas clásicamente histiocitosis X, y en la actualidad histiocitosis de células de Langerhans, debido a que se conoce que es causada por la proliferación de esta estirpe celular. Se presenta un caso clínico de granuloma eosinófilo unifocal de hueso temporal en un adulto, y se realiza una revisión bibliográfica acerca del diagnóstico, pronóstico, tratamiento y seguimiento que precisan estos pacientes. Asimismo se resalta la importancia de realizar un análisis completo de todas las estructuras anatómicas en las pruebas por imágenes, para así hacer un diagnóstico lo más precoz y detallado posible. El tratamiento de elección consistirá en la extirpación quirúrgica de la tumoración, reservándose la radioterapia sólo para lesiones no accesibles o no resecables en su totalidad. El pronóstico del granuloma eosinófilo unifocal es muy bueno, obteniéndose control de la enfermedad en el 95 por ciento de los casos (AU)
Eosinophilic granuloma is one of the diseases of unknown etiology traditionally known as histiocytosis X and now called histiocytosis of the Langerhans cells since it has been found to originate by proliferation of this cell line. We report a clinical case of unifocal eosinophilic granuloma of the temporal bone in an adult. We reviewed the literature on the diagnosis, prognosis, treatment, and assessment of these patients. The importance of making a thorough analysis of all the anatomical structures in imaging is emphasized as a way of making a precise early diagnosis. The treatment of choice is surgical removal of the tumor. Irradiation is used for inaccessible or incompletely resected lesions. The prognosis of unifocal eosinophilic granuloma is very good, with successful disease control being achieved in 95% of cases (AU)
Asunto(s)
Adulto , Femenino , Humanos , Hueso Temporal , Histiocitosis de Células de Langerhans/diagnóstico , Enfermedades Óseas/diagnóstico , Enfermedades Óseas/cirugía , Enfermedades Óseas/fisiopatología , Histiocitosis de Células de Langerhans/fisiopatología , Histiocitosis de Células de Langerhans/cirugía , Potenciales Evocados AuditivosRESUMEN
Eosinophilic granuloma is one of the diseases of unknown etiology traditionally known as histiocytosis X and now called histiocytosis of the Langerhans cells since it has been found to originate by proliferation of this cell line. We report a clinical case of unifocal eosinophilic granuloma of the temporal bone in an adult. We reviewed the literature on the diagnosis, prognosis, treatment, and assessment of these patients. The importance of making a thorough analysis of all the anatomical structures in imaging is emphasized as a way of making a precise early diagnosis. The treatment of choice is surgical removal of the tumor. Irradiation is used for inaccessible or incompletely resected lesions. The prognosis of unifocal eosinophilic granuloma is very good, with successful disease control being achieved in 95% of cases.
Asunto(s)
Enfermedades Óseas , Histiocitosis de Células de Langerhans , Hueso Temporal , Adulto , Enfermedades Óseas/diagnóstico , Enfermedades Óseas/fisiopatología , Enfermedades Óseas/cirugía , Potenciales Evocados Auditivos , Femenino , Histiocitosis de Células de Langerhans/diagnóstico , Histiocitosis de Células de Langerhans/fisiopatología , Histiocitosis de Células de Langerhans/cirugía , HumanosRESUMEN
Tumours located in the salivary glands form the most heterogeneous group in all human oncological pathology. They show various epidemiological, clinical and evolutionary characteristics which separate them from other neoplasms of the head and neck. In this paper, we have carried out a study on their epidemiological aspects, collecting 80 cases diagnosed in the ENT Service of the University Hospital Complex of Santiago over 17 years. The incidence was 1.22 cases per 100,000 inhabitants per year. The frequency was higher in males (58.75%) and in the 7th decade of age. A predominance was noticed in females under 40 years of age and in males over this age, but the differences were not statistically significant. The most frequent site was the parotid gland, and we could not find any case in the sublingual gland. In 52.5% of cases the tumour was benign, pleomorphic adenoma being the most prevalent. Among malignant tumours, the epidermoid carcinoma stood out in our series. The prevalence of benign tumours in females and of malignant tumours in males was clear, with significant differences. We compare our results with the data published in the literature.
Asunto(s)
Neoplasias de las Glándulas Salivales/epidemiología , Adulto , Áreas de Influencia de Salud , Femenino , Humanos , Masculino , España/epidemiologíaRESUMEN
Report of 2 chemodectoma cases diagnosed in the ENT-Department (Prof. Labella) at C.H.U.S. The condition could be suspected because a tinnitus aurium and the transtympanic reddish image by otoscopy. And diagnosis settled through imaging techniques (computed tomography, magnetic resonance and selective angiography). Surgical treatment.
Asunto(s)
Neoplasias del Oído/diagnóstico , Paraganglioma Extraadrenal/diagnóstico , Membrana Timpánica/diagnóstico por imagen , Membrana Timpánica/patología , Angiografía Cerebral , Neoplasias del Oído/cirugía , Femenino , Humanos , Imagen por Resonancia Magnética , Persona de Mediana Edad , Paraganglioma Extraadrenal/cirugía , Tomografía Computarizada por Rayos X , Membrana Timpánica/cirugíaRESUMEN
To date, only 45 cases of oat cell carcinoma of the major salivary glands have been reported in the literature, which represents less than 1% of primary malignant tumors of the parotid glands. Two subtypes exist: ductal and neuroendocrine. We report two new cases of neuroendocrine oat cell carcinoma of the parotid gland which were treated by surgery associated with radiation therapy and chemotherapy. The literature review showed a predominance of males (61.7%), age 50-70 years, and location in parotid gland (83%). Treatment consists of radical surgery of the tumor associated with radiation therapy and chemotherapy. The prognosis is poor, with survivals at one, three and five years of 77.7%, 40.7%, and 29.6%, respectively, although this is better than the prognosis for other sites.
Asunto(s)
Carcinoma de Células Pequeñas/patología , Neoplasias de las Glándulas Salivales/patología , Anciano , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Retrospective study about 10 verrucous carcinomas of the larynx surgically treated in a 20-year-term. This variety accounted por the 1.9 percent of the cancers seen in that period of time. Tabagism and alcoholism predominated in 8 and 6 patients respectively. Glottis was the localization and dysphony the paramount symptom. In the paper are emphasized the most important histologic features. Koilocytosis was present in 6 cases. Four patients developed a second tumor of epidermoid carcinoma type. No one exitus due to the verrucous growth. Only in 3 the death was attributed to the second malignancy.
Asunto(s)
Carcinoma Verrugoso/patología , Neoplasias Laríngeas/patología , Laringe/patología , Adulto , Anciano , Carcinoma Verrugoso/radioterapia , Carcinoma Verrugoso/cirugía , Humanos , Neoplasias Laríngeas/radioterapia , Neoplasias Laríngeas/cirugía , Laringe/cirugía , Masculino , Persona de Mediana Edad , Estudios RetrospectivosRESUMEN
Presenting a study about Human Papillomavirus (HPV) determination by immunohistochemistry and "in situ" hybridization, in 25 samples of squamous cell papillomata (15 tonsilar and 10 laryngeal lesions). Five cases resulted positive for HPV: 2 of them for immunohistochemical probes, other 2 for "in situ" hybridization and only 1 cas showed its positivity for both techniques. All these samples belonging to laryngeal cases. No significant differences were found in antecedents, clinical and histological features related with results obtained. Two patients developed a laryngeal carcinoma after papilloma and they had positive "in situ" hybridization. Literature about diagnosis of HPV-infection was revised.
Asunto(s)
Neoplasias Laríngeas/virología , Papiloma/virología , Papillomaviridae/aislamiento & purificación , Neoplasias Tonsilares/virología , Adulto , ADN Viral/análisis , Femenino , Humanos , Inmunohistoquímica , Hibridación in Situ , MasculinoRESUMEN
Waldeyer's ring is a relatively common location for non-Hodgkin's lymphoma. Here, we report an epidemiological study of Waldeyer's ring lymphomas based on data for 55 cases treated over a 19-year period at three centers in northern Spain. In most respects our results confirm those of previous studies. The average delay between first consultation and diagnosis was 3.8 months, and was longer for nasopharyngeal lymphomas than for tonsillar lymphomas.
Asunto(s)
Linfoma no Hodgkin/epidemiología , Neoplasias de la Boca/epidemiología , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , España/epidemiologíaRESUMEN
The incidence of p53 antigen and human papillomavirus (HPV) expression in archival formalin-fixed, paraffin-embedded tissue sections from verrucous carcinoma of the larynx was determined using immunohistochemistry. The p53 oncoprotein was detected in four of 10 tissue samples (40 per cent). The same number of tumours had HPV antigen, and three cases had both p53 oncoprotein and HPV antigen. All positive cases were from heavy smokers and drinkers. After surgical treatment, no tumour recurrence was present in our series. Four patients developed a second head and neck neoplasm and death occurred in three. Three of the patients with second tumour had p53 positive immunoreactivity and two had p53 and HPV expression. Verrucous carcinoma of the larynx presented with overexpression of p53 antigen in a similar percentage to other head and neck cancers. The p53 immunohistochemical determination is well correlated with HPV detection and could have prognostic value in these tumours, but no statistical evidence was present.
Asunto(s)
Antígenos Virales/análisis , Carcinoma Verrugoso/virología , Neoplasias Laríngeas/virología , Papillomaviridae/inmunología , Proteína p53 Supresora de Tumor/análisis , Adulto , Anciano , Consumo de Bebidas Alcohólicas/efectos adversos , Biomarcadores de Tumor/análisis , Carcinoma Verrugoso/química , Carcinoma Verrugoso/etiología , Neoplasias de Cabeza y Cuello/química , Neoplasias de Cabeza y Cuello/etiología , Neoplasias de Cabeza y Cuello/virología , Humanos , Inmunohistoquímica , Neoplasias Laríngeas/química , Neoplasias Laríngeas/etiología , Masculino , Persona de Mediana Edad , Neoplasias Primarias Secundarias/química , Neoplasias Primarias Secundarias/etiología , Neoplasias Primarias Secundarias/virología , Fumar/efectos adversosRESUMEN
The clinical, diagnostic, and therapeutic features of 257 papillomas of the ear, nose and throat were studied. These tumors were found in a population of about 500,000 inhabitants over a 20-year period (1973-1992). The clinical manifestations of papillomas were varied and more dependent on location than on the size or number of lesions. The most frequent symptom was a foreign body sensation. Twenty-four percent of cases were asymptomatic and the diagnosis was made during a general physical examination; such diagnoses were most frequent in the pharynx. The mean duration of symptoms before visiting a physician was 10 months (longer in papilloma of the oral cavity and shorter in the pharynx). The initial clinical diagnosis was correct in 63% of cases. Lesions of the oral cavity presented most diagnostic problems and those of the pharynx the least. A clinical diagnosis of cancer was made most often in the larynx. Treatment was surgical in every case. Twenty percent required more than one operation to remove the papilloma.
Asunto(s)
Neoplasias Laríngeas/diagnóstico , Laringe/patología , Neoplasias de la Boca/diagnóstico , Papiloma/diagnóstico , Neoplasias Faríngeas/diagnóstico , Adolescente , Adulto , Anciano , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Neoplasias Laríngeas/patología , Neoplasias Laríngeas/cirugía , Laringe/cirugía , Masculino , Persona de Mediana Edad , Boca/patología , Boca/cirugía , Neoplasias de la Boca/patología , Neoplasias de la Boca/cirugía , Papiloma/patología , Papiloma/cirugía , Neoplasias Faríngeas/patología , Neoplasias Faríngeas/cirugía , Faringe/patología , Faringe/cirugíaRESUMEN
Tumors of the mastoid portion of the facial nerve are rare and often are misdiagnosed because they have subtle clinical manifestations. We have described three cases of tumor affecting the mastoid portion of the facial nerve seen in our hospital. In all cases, diagnosis proved problematic. Routine and careful use of imaging techniques and a certain amount of intuition are necessary to reach the correct diagnosis. Facial paralysis diagnosis requires histopathological examination following mastoidectomy.
Asunto(s)
Condroma/complicaciones , Neoplasias de los Nervios Craneales/complicaciones , Nervio Facial/patología , Parálisis Facial/etiología , Apófisis Mastoides/fisiopatología , Neuroma/complicaciones , Anciano , Condroma/patología , Neoplasias de los Nervios Craneales/patología , Femenino , Humanos , Masculino , Apófisis Mastoides/cirugía , Persona de Mediana Edad , Neuroma/patologíaRESUMEN
We present a study of the incidence of squamous cell papillomas on the otorhinolaryngological field, in a population of approximately 500,000 inhabitants between 1973 and 1992. We have reviewed 234 papillomas. The overall incidence of ENT papillomas was 2.4737 x 10(5) inhabitants per year. The most frequent location was the pharynx, followed by oral cavity, larynx and sinonasal tract. In the ear these lesions were very rare. No significant increase in incidence rates were found over the four year periods, except for pharyngeal papillomas. The median age at onset of ENT papillomas was 47.11 years (range = 4 to 83 years). Only 7,3% of papillomas were of juvenile type. The male to female ratio was 2,1. Male preponderance occurred in pharyngeal and laryngeal papillomas. Only lesions of the ear were most frequent in the female population. 54,9% of patients were smokers. The highest incidence of smoking habit was found in laryngeal papillomas. Only two patients in our series had HIV infection, and in both cases the papillomas were located in the oral cavity. This study shows that the incidence of ENT papillomas has remained constant and that adult preponderance is more marked in our population than in others reported previously. The pathogenesis of the ENT squamous papillomas in our population is related with an acquired HPV infection without clear relation to genital disease.