RESUMEN
BACKGROUND: Binge drinking (the consumption of large quantities (>5 units) of alcohol in a short period) is associated with increased cardiovascular mortality. Wine polyphenols are considered to be protective against cardiovascular diseases. We conducted an experimental study to evaluate the acute effects of alcohol consumption on flow-mediated vasodilation and general cardiovascular parameters, using beverages with high polyphenolic content (HPC) and low polyphenolic content (LPC). METHODS: Two groups of ten volunteers were asked to drink two different kinds of beverages. in 45 minutes, three units of red wine or an alcoholic beverage with a low polyphenolic count were consumed. Then 45 minutes were allowed for complete uptake of the alcohol or polyphenolic compounds. Next, all volunteers underwent blood pressure readings, ECG and flow-mediated vasodilation. Blood samples were taken at the same time for routine chemistry, inflammation parameters and lipids. Then the entire cycle was repeated once (in total six units of alcohol in 180 minutes). RESULTS: No differences were found between the two drinks. Alcohol itself dose-dependently increased forearm blood flow by vasodilation of both arterioles and distribution arteries. However, flow-mediated vasodilation (FMD) for the LPC group (n=10) decreased from 7.31 +/- 4.78 (% +/- sd) to 2.82 +/- 2.9 after three drinks and 1.21 +/- 3.25 after six drinks. The FMD values for the HPC group (n=10) decreased from 8.61 +/- 1.78 to 1.78 +/- 3.71 and 1.19 +/- 2.6. There were no significant changes between the LPC and the LPC group at the three time points. CONCLUSION: Although ethanol produces vasodilation at the level of the distribution artery as well as at an arteriolar level, it causes a decrease in flow-mediated vasodilation. This endothelial dysfunction is not corrected by the polyphenols present in wine.
Asunto(s)
Consumo de Bebidas Alcohólicas/fisiopatología , Endotelio Vascular/fisiopatología , Etanol/envenenamiento , Flavonoides/farmacología , Fenoles/farmacología , Vino/análisis , Adulto , Presión Sanguínea/efectos de los fármacos , Relación Dosis-Respuesta a Droga , Electrocardiografía , Femenino , Flavonoides/análisis , Humanos , Masculino , Fenoles/análisis , Polifenoles , Vasodilatación/efectos de los fármacosRESUMEN
BACKGROUND: Acute, excessive alcohol intake has been associated with an increased cardiovascular mortality in otherwise healthy individuals. It predisposes to accelerated atherosclerosis resulting in acute coronary events but also arrhythmias have been described, such as atrial fibrillation and life-threatening re-entrant ventricular arrhythmias. QTc prolongation is associated with an increased risk of ventricular tachyarrhythmias and an independent risk factor for sudden cardiac death. The aim of the study is to investigate the effect of binge drinking on the conduction intervals in healthy individuals. METHODS: Ten of the volunteers drank red wine while the other ten volunteers drank a sweet designer drink. A follow-up of blood pressure, heart rate, ECG and laboratory findings was performed at an ethanol level of 0, 0.4 and 0.8%, respectively. RESULTS: Fifteen volunteers showed a prolongation of the PR interval, 13 of the QRS complex, 9 of the QT interval and 13 of the QTc interval. PR interval increased from 149 +/- 16 ms to 163 +/- 11 ms (p < 0.05). The heart rate-adjusted QT interval increased from 400 +/- 24 ms to 426 +/- 52 ms (p < 0.05). Heart rate and systolic blood pressure did not significantly change due to the ingestion. CONCLUSION: Acute ingestion of alcohol in a healthy population can induce prolongation of PR and QTc interval.
Asunto(s)
Intoxicación Alcohólica/complicaciones , Electrocardiografía , Sistema de Conducción Cardíaco/fisiopatología , Síndrome de QT Prolongado/inducido químicamente , Adulto , Etanol/sangre , Femenino , Humanos , Síndrome de QT Prolongado/diagnóstico , Masculino , Persona de Mediana Edad , Probabilidad , Estudios Prospectivos , Medición de Riesgo , Muestreo , Sensibilidad y EspecificidadRESUMEN
The purpose of this study was to determine the value of the ECG in subarachnoid hemorrhage (SAH) in predicting poor outcome, and to define if specific ECG changes are related to the location of the aneurysm in SAH. A retrospective cohort study was performed on 97 patients with symptoms of SAH. An ECG and an initial computer tomograph (CT) scan were the two major inclusion criteria. The primary endpoint was in hospital mortality. ECG changes were correlated with mortality and severity of hemorrhage expressed as the Hijdra score. A prolonged QTc interval occurred more frequently in patients who had experienced a severe hemorrhage (RR = 3.18; 95% CI = 1.07-10.22; P < 0.05). LV hypertrophy criteria were strongly related to an aneurysm in the anterior communicating artery. U wave presence showed a statistically significant relationship with the posterior communicating artery and the middle cerebral artery. A prolonged QTc interval is observed more frequently in patients with severe hemorrhage. Specific ECG abnormalities were seen to be associated with the location of the aneurysm in the circle of Willis in SAH.