RESUMEN

The synthesis of a set of substituted 3-aryl-7-hydroxycoumarins was performed. The study of the relations between their structure and their relative binding affinity (RBA) to human alpha and B estrogen receptors was achieved.

Asunto(s)

Cumarinas/síntesis química , Receptores de Estrógenos/metabolismo , Células Cultivadas , Cumarinas/metabolismo , Receptor alfa de Estrógeno , Receptor beta de Estrógeno , Humanos , Indicadores y Reactivos