RESUMEN
Breast cancer continues to be a major health problem for women in the USA and worldwide. There is a need to identify and take steps to alter modifiable breast cancer risks. Conditions of obesity and overweight are risk factors that have reached epidemic proportions. This article reviews the evidence in the literature that test mechanism-based hypotheses which attempt to provide a molecular basis for a causal link between obesity and breast cancer risk, particularly the effects of metabolic syndrome and insulin resistance, peripheral estrogen aromatization in adipose tissue, and direct effect of adipokines. Future areas for study and implications for therapy are discussed.
Asunto(s)
Neoplasias de la Mama/etiología , Estrógenos/metabolismo , Insulina/metabolismo , Obesidad/complicaciones , Adipocitos/metabolismo , Neoplasias de la Mama/metabolismo , Neoplasias de la Mama/terapia , Femenino , Humanos , Resistencia a la Insulina , Obesidad/metabolismo , Obesidad/terapiaRESUMEN
Rattus norvegicus has been considered nonphotoperiodic, but Fischer 344 (F344) rats are inhibited in growth and reproductive development by short photoperiod (SD). We tested photoresponsiveness of the genetically divergent Brown Norway (BN) strain of rats. Peripubertal males were tested in long photoperiod or SD, with or without 30% food reduction. Young males were photoresponsive, with reductions in testis size, body mass, and food intake in SD and with enhanced responses to SD when food restricted. Photoperiods < or =11 h of light inhibited reproductive maturation and somatic growth, whereas photoperiods of 12 h or more produced little or no response. F344/BN hybrids differ from both parent strains in the timing, amplitude, and critical photoperiod of photoperiodic responses, indicating genetic differences in photoperiodism between these strains. This is consistent with the hypothesis that ancestors of laboratory rats were genetically variable for photoperiodism and that different combinations of alleles for photoperiodism have been fixed in different strains of rats.