RESUMEN
A sample of children treated by phototherapy during the neonatal period has been studied in the population of Penne (South Eastern Italy) in order to confirm the association previously reported in newborns from the population of Rome between neonatal jaundice and phenotypes of adenosine deaminase (ADA) and acid phosphatase (ACP1). The present data confirm that the incidence of clinically relevant jaundice is much greater in newborns of phenotype ACP1 BA carrying ADA2 allele than in other infants. Since ACP1 probably acts as flavin mononucleotide phosphatase and is modulated by purine nucleotides, it is likely that enzymes of purine nucleotide metabolism (including ADA), ACP1 and flavoenzymes (including gluthatione reductase and enzymes of Krebs cycle), may represent a polygenic complex influencing bilirubin levels in the first few days of life.
Asunto(s)
Fosfatasa Ácida/genética , Adenosina Desaminasa/genética , Ictericia Neonatal/enzimología , Nucleósido Desaminasas/genética , Femenino , Humanos , Recién Nacido , Italia , Ictericia Neonatal/genética , Ictericia Neonatal/terapia , Masculino , Fenotipo , Fototerapia , Polimorfismo GenéticoRESUMEN
A statistical assessment was made of the results obtained in a study of the behaviour of the protidogram and serum agglutinins in rabbits subjected to Salmonella typhi murium vaccination and 25 and 50 mg/kg per day gastric mucoprotein. Albumin values were decreased in animals both vaccinated and treated, moderately increased in those that received mucoprotein only. Globulins increased in both groups. Antibody increases were most marked in animals vaccinated and treated with the larger mucoprotein dose.