RESUMEN
BACKGROUND: Although the concordance between cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers and amyloid-PET findings is well known, there are no data regarding the concordance of amyloid-PET with inconclusive CSF values of amyloid-ß (Aß)1 - 42 and p-tau for the diagnosis of AD. OBJECTIVE: To investigate the relationship between the amyloid-PET results with discordant AD biomarkers values in CSF (Aß1 - 42+/p-tau-or Aß1 - 42-/p-tau+). METHODS: An observational retrospective study, including 62 patients with mild cognitive impairment (32/62) or dementia (30/62), suspicious of AD who had undergone a lumbar puncture to determine CSF AD biomarkers, and presented discordant values in CSF between Aß1 - 42 and p-tau (Aß1 - 42+/p-tau-or Aß1 - 42-/p-tau+). All of them, underwent an amyloid-PET with 18F-Florbetaben. An extensive neuropsychological testing as part of their diagnostic process (MMSE and TMA-93), was performed, and it was also obtained the Global Deterioration Scale. RESULTS: Comparing the discordant CSF results of each patient with the cerebral amyloid-PET results, we found that in the group with Aß1 - 42+ and p-tau-CSF values, the amyloid-PET was positive in 51.2% and negative in 48.8% of patients, while in the group with Aß1 - 42-and p-Tau+ CSF values, the amyloid-PET was positive in 52.6% of patients and negative in 47.4% of them. No significant association was found (pâ=â0.951) between the results of amyloid-PET and the two divergent groups in CSF. CONCLUSIONS: No significant relationship was observed between the results of discordant AD biomarkers in CSF and the result of amyloid-PET. No trend in amyloid-PET results was observed in relation to CSF biomarker values.
Asunto(s)
Enfermedad de Alzheimer , Disfunción Cognitiva , Humanos , Enfermedad de Alzheimer/diagnóstico , Proteínas tau/líquido cefalorraquídeo , Estudios Retrospectivos , Péptidos beta-Amiloides/líquido cefalorraquídeo , Disfunción Cognitiva/diagnóstico por imagen , Disfunción Cognitiva/líquido cefalorraquídeo , Tomografía de Emisión de Positrones , Biomarcadores/líquido cefalorraquídeo , Fragmentos de Péptidos/líquido cefalorraquídeoRESUMEN
â¢HaNDL syndrome may be a condition probably underdiagnosed in pediatric age.â¢A differential diagnosis with viral, vascular or autoimmune etiology is necessary.â¢Epileptiform alterations in EEG could be possible in this infrequent syndrome.â¢99mTc-HMPAO SPECT provides a potential role in the differential diagnostic and management.
RESUMEN
No disponible
Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Vasculitis/diagnóstico por imagen , Vasculitis/tratamiento farmacológico , Fluorodesoxiglucosa F18/administración & dosificación , Fiebre de Origen Desconocido/complicaciones , Tomografía Computarizada por Tomografía de Emisión de Positrones , Fiebre de Origen Desconocido/etiología , Astenia/etiología , Corticoesteroides/administración & dosificaciónAsunto(s)
Fiebre de Origen Desconocido/etiología , Tomografía Computarizada por Tomografía de Emisión de Positrones , Vasculitis/diagnóstico por imagen , Corticoesteroides/uso terapéutico , Radioisótopos de Flúor , Fluorodesoxiglucosa F18 , Humanos , Masculino , Persona de Mediana Edad , Radiofármacos , Sensibilidad y Especificidad , Vasculitis/complicaciones , Vasculitis/tratamiento farmacológicoRESUMEN
No disponible