RESUMEN
The trial entered 49 patients with epididymitis and 18 age-matched control subjects without this disease. The patients were divided into 3 groups: 21 patients of group 1 were treated surgically (epididymotomy with drainage of the scrotal cavity), 15 patients of group 2 were inoperable, 13 patients of group 3 suffered from exacerbation of chronic epididymitis. Before treatment the patients were examined clinically, bacteriologically and immunologically. Measured were: main populations and subpopulations of lymphocytes using indirect immunofluorescence and monoclonal antibodies; concentration of serum immunoglobulins using radial immunodiffusion; overall content of circulating immune complexes precipitating by polyetilene glycol-6000; phagocytosing neutrophil function by absorption of latex particles. The immunogram of epididymitis patients was indicative of the inflammation stage and activity which is important for choice of treatment. Immunogram of group 1 patients was characteristic of the peak of acute inflammation, of group 2 was typical for attenuation of acute inflammation. Immunogram of group 3 patients corresponded to exacerbation of chronic inflammation and secondary immunodeficiency.
Asunto(s)
Epididimitis/inmunología , Enfermedad Aguda , Adulto , Análisis de Varianza , Formación de Anticuerpos , Enfermedad Crónica , Epididimitis/etiología , Epididimitis/terapia , Humanos , Inmunidad Celular , Masculino , Persona de Mediana EdadRESUMEN
The paper is concerned with the results of studying the concentration of circulating immune complexes and immune system (the number of lymphocyte populations and subpopulations in the peripheral blood, the level of serum immunoglobulins) in 45 patients aged 10 to 72 years with hemorrhagic vasculitis depending on the disease pattern and course before and after the treatment. The patients suffering from hemorrhagic vasculitis manifested appreciable changes in humoral immunity and negligible derangement of cellular immunity associated with dramatic enhancement of complex formation. The intensity of the alterations was discovered to be dependent on the pattern and course of the disease.
Asunto(s)
Complejo Antígeno-Anticuerpo/sangre , Vasculitis por IgA/inmunología , Sistema Inmunológico/inmunología , Adolescente , Adulto , Anciano , Linfocitos B/inmunología , Niño , Femenino , Humanos , Vasculitis por IgA/complicaciones , Inmunoglobulinas/análisis , Masculino , Persona de Mediana Edad , Formación de Roseta , Linfocitos T/inmunologíaAsunto(s)
Anemia Hemolítica Autoinmune/tratamiento farmacológico , Enfermedades Autoinmunes/tratamiento farmacológico , Leucemia Linfocítica Crónica de Células B/inmunología , Levamisol/uso terapéutico , Púrpura Trombocitopénica Trombótica/tratamiento farmacológico , Adyuvantes Inmunológicos , Anemia Hemolítica Autoinmune/etiología , Enfermedades Autoinmunes/etiología , Humanos , Púrpura Trombocitopénica Trombótica/etiologíaRESUMEN
The experiments on guinea pigs and male CBA mice have shown that short-term daily administration of lipidin-2 (3 infusions) in a dose of 2 g/kg induces a decrease in T-lymphocyte proliferative activity. Increased multiplicity of the agent infusions up to 7 and 14 is attended by reversible quantitative and functional changes in the T-lymphocyte population and D-cells.
Asunto(s)
Emulsiones Grasas Intravenosas/farmacología , Inmunidad Celular/efectos de los fármacos , Fosfolípidos/farmacología , Aceites de Plantas/farmacología , Animales , Grasas Insaturadas en la Dieta/administración & dosificación , Grasas Insaturadas en la Dieta/farmacología , Emulsiones , Emulsiones Grasas Intravenosas/administración & dosificación , Glicerol , Cobayas , Recuento de Leucocitos/efectos de los fármacos , Masculino , Ratones , Ratones Endogámicos CBA , Nutrición Parenteral , Fosfolípidos/administración & dosificación , Aceites de Plantas/administración & dosificación , Aceite de Girasol , Linfocitos T/efectos de los fármacos , Linfocitos T/inmunología , Factores de TiempoAsunto(s)
Adyuvantes Inmunológicos , Emulsiones Grasas Intravenosas/farmacología , Animales , Cobayas , Masculino , RatasAsunto(s)
Anemia Hemolítica Congénita/inmunología , Reacciones Antígeno-Anticuerpo , Esferocitosis Hereditaria/inmunología , Adolescente , Adulto , Anemia Hemolítica Congénita/terapia , Colecistectomía , Colelitiasis/inmunología , Colelitiasis/cirugía , Humanos , Inmunidad Celular , Inmunoglobulinas/análisis , Recuento de Leucocitos , Persona de Mediana Edad , Periodo Posoperatorio , Esferocitosis Hereditaria/terapia , EsplenectomíaRESUMEN
Hemophiliac patients develop disorders of the immune status as a result of transfusion therapy: a decrease in the number of T-lymphocytes and the ratio T-helpers/T-suppressors resulting from a decrease in the number of T-helpers, enhancement of immunoglobulinogenesis, and an increase in the level of circulating immune complexes. A degree of the above changes depends on a dose and period of the use of antihemophilic drugs. Hemophiliac patients require immunological monitoring, clinical substantiation of doses and a prolonged period of administration of blood preparations.
Asunto(s)
Hemofilia A/complicaciones , Enfermedades del Sistema Inmune/etiología , Enfermedad Aguda , Adolescente , Adulto , Transfusión Sanguínea , Relación Dosis-Respuesta Inmunológica , Factor VIII/administración & dosificación , Hemofilia A/inmunología , Hemofilia A/terapia , Hemofilia B/complicaciones , Hemofilia B/inmunología , Hemofilia B/terapia , Hemorragia/etiología , Hemorragia/inmunología , Humanos , Enfermedades del Sistema Inmune/inmunología , Enfermedades del Sistema Inmune/terapia , Inmunidad Celular , Inmunoglobulinas/análisis , Factores de TiempoRESUMEN
The populations of lymphocytes and serum immunoglobulins were explored in 20 patients with erythremia, 26 patients with sub-leukemic myelosis, 38 patients with pronounced chronic myeloid leukemia, and 33 patients with the blastic phase of the illness. The patients with chronic myeloproliferative diseases manifested cellular immunodeficiency that was aggravated as the disease progressed. In the pronounced stage, the patients showed relative preservation of humoral immunity whereas in the terminal stage they developed humoral deficiency. Study of the time-course of changes in the immunological characteristics has demonstrated that deterioration of the characteristics starts during blast transformation of myeloproliferative diseases. This may serve as a criterion for predicting exacerbations and early diagnosis of the blastic phase.
Asunto(s)
Trastornos Mieloproliferativos/inmunología , Adolescente , Adulto , Anciano , Formación de Anticuerpos , Linfocitos B/inmunología , Enfermedad Crónica , Humanos , Inmunidad Celular , Inmunoglobulinas/análisis , Recuento de Leucocitos , Linfocitos Nulos/inmunología , Persona de Mediana Edad , Pronóstico , Linfocitos T/inmunologíaAsunto(s)
Leucemia Linfoide/inmunología , Adolescente , Adulto , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Humanos , Inmunoglobulinas/análisis , Leucemia Linfoide/tratamiento farmacológico , Recuento de Leucocitos/efectos de los fármacos , Leucocitos/inmunología , Persona de Mediana Edad , Muramidasa/sangreAsunto(s)
Anemia Hemolítica Congénita/terapia , Inmunidad , Esplenectomía , Adolescente , Adulto , Niño , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
117 patients with breast cancer were subjected to a comparative study for immune complexes by the polyethylene glycol precipitation method, T-lymphocytes by the E-rosette test, serum immunoglobulins by immunodiffusion as well as for lymphocyte blast transformation in response to PHA. The level and incidence of immune complexes were elevated. An increase in the tumour mass with stages is associated with high levels of circulating immune complexes. No relationship was found between morphology of the tumour and the level or incidence of immune complexes. In latest stages (III-IV) the level of immune complexes correlated significantly with depletion of T lymphocytes or their response to PHA, and also with concentration of serum IgM. The results suggest that immune complexes may function as a specific blocking factor in the course of oncological disease.
Asunto(s)
Complejo Antígeno-Anticuerpo/análisis , Neoplasias de la Mama/inmunología , Adulto , Anciano , Formación de Anticuerpos , Femenino , Humanos , Inmunidad Celular , Inmunoglobulina M/análisis , Persona de Mediana Edad , Formación de Roseta , Linfocitos T/inmunologíaRESUMEN
The level and possible pathologic relevance of circulating immune complexes (ICs) were investigated by polyethylene glycol precipitation method in sera of 109 untreated cancer patients (melanoblastoma, lung and breast cancer) and 118 patients with various immune complex diseases (collagenosis, nephropathia, vasculitis and immune hemocytopenia). The highest level of ICs was established in all patients with melanoblastoma. The raised concentration of ICs was registered in patients with malignancies of lung and breast (42 and 44%, respectively). A relationship between increased level of ICs and the rate of its growth in breast cancer patients, on the one hand, and clinical stage of the disease, on the other, was shown. The pathogenic effects of ICs in malignancies and immune complex diseases are compared.