Asunto(s)
Anafilaxia/inducido químicamente , Excipientes/efectos adversos , Polisorbatos/efectos adversos , Corticoesteroides/administración & dosificación , Anafilaxia/diagnóstico , Anafilaxia/tratamiento farmacológico , Anafilaxia/inmunología , Antialérgicos/uso terapéutico , Composición de Medicamentos , Femenino , Humanos , Inyecciones Intramusculares , Pruebas Intradérmicas , Dolor de la Región Lumbar/tratamiento farmacológico , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Resultado del TratamientoRESUMEN
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Asunto(s)
Humanos , Masculino , Femenino , Persona de Mediana Edad , Polisorbatos/efectos adversos , Polisorbatos/análisis , Excipientes/efectos adversos , Excipientes/uso terapéutico , Anafilaxia/inducido químicamente , Anafilaxia/diagnóstico , Corticoesteroides/efectos adversos , Corticoesteroides/uso terapéutico , Pruebas Cutáneas/métodos , Pruebas Cutáneas , Hipersensibilidad a las Drogas/complicaciones , Hipersensibilidad a las Drogas/diagnósticoRESUMEN
The Drug Allergy Committee of the Spanish Society of Allergology and Clinical Immunology reviewed the allergenic potential of several substances of food origin that are found in the composition of some drugs. Despite recent legislation on labeling, many labels do not clearly state whether the drug contains raw material (active ingredients, excipient, or other manufacturing intermediate) with an origin in any of the substances in the list of the 14 groups of food allergens that are subject to mandatory declaration. The objective of legislation is that the drug package, the Summary of Product Characteristics, and the patient information leaflet clearly state the food content in order to improve the safety of allergic patients. Therefore, any food or allergen derivative that must be declared should be clearly stated on the drug label. Of all the evaluated products, egg and milk derivatives are the most frequently discussed in literature reviews. The natural or synthetic origin of potentially allergenic substances such as lysozyme, casein, lactose, albumin, phosphatide, and aromatic essences should be clearly stated. Providing this information has 2 clear advantages. First, allergic reactions to drugs in patients with food allergy could be avoided (if the substances have a natural origin). Second, prescription would improve by not restricting drugs containing synthetic substances (which do not usually induce allergic reactions).
Asunto(s)
Hipersensibilidad a las Drogas/etiología , Aditivos Alimentarios/efectos adversos , Hipersensibilidad a los Alimentos/etiología , Glucosamina/efectos adversos , Humanos , Lactosa/efectos adversos , Muramidasa/efectos adversos , Ovalbúmina/efectos adversos , Propofol/efectos adversos , EspañaRESUMEN
BACKGROUND AND OBJECTIVE: Contradictory reports of the sensitivity of skin tests in quinolone allergy have been reported. Our objectives were to describe the outcome of quinolone skin and challenge tests in patients consulting because of a history of adverse reaction to quinolone and to compare the outcome of quinolone skin tests and challenge tests in the subsample of patients who had undergone both tests. METHODS: We reviewed skin and challenge test results of all patients who consulted at our allergy service over the last 5 years because of a history of quinolone adverse reaction in the form of urticaria or anaphylaxis within 1 hour of drug intake (group 1), urticaria or maculopapular eruption between 1 and 24 hours after intake (group 2) or after 24 hours had passed (group 3), or atypical symptoms (group 4). RESULTS: A total of 71 cases were identified: 27, 8, 24 and 12 in groups 1 through 4, respectively. Skin tests were performed in all patients, with positive results in 31 patients. In group 1, 62.9 % of these patients showed positive skin tests and 22.2% showed positive challenge tests, whereas in the other 3 groups, about 30% of patients had positive skin tests and a variable percentage (from 0% to 4.1% depending on the group) had positive challenge tests. Quinolone challenge tests were performed in 10 patients with positive skin tests (5 of them with positive results) and in 34 patients with negative skin tests (2 of them with positive results). CONCLUSIONS: A highly suggestive history of quinolone allergy is more frequently associated with positive skin tests and positive challenge tests. Therefore, skin tests help to predict the result of the challenge test.
Asunto(s)
Antiinfecciosos/efectos adversos , Hipersensibilidad a las Drogas/diagnóstico , Quinolonas/efectos adversos , Adulto , Anciano , Anciano de 80 o más Años , Reacciones Cruzadas , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Pruebas CutáneasRESUMEN
Anisakis simplex is a nematode which parasitizes mainly fish and cephalopods and accidentally human beings after ingestion. Apart from the different digestive syndromes, this organism has recently been involved as cause of IgE-mediated allergic reactions of variable degree (urticaria to severe angioedema). In this report three patients with the diagnosis of allergy to Anisakis simplex are reported and a review of the literature is made.
Asunto(s)
Anisakis/inmunología , Urticaria/parasitología , Adulto , Animales , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
We present two cases of cutaneous erythroderma induced by carbamazepine therapy, both cases with just cutaneous affection and only one suspicious drug. A cutaneous patch study, with standard battery from the Spanish Contact Dermatitis Research Group, vaseline with carbamazepine at 10% and lectures at 48 and 96 hours, was conducted. The result was positive for carbamazepine and negative for all other patches in both cases. All controls were negative. This is a very simple test, easy to perform, specific and with low side effects, allowing the diagnosis of this pathology.