RESUMEN
Overall 30 patients with multiple myeloma (MM) were examined for immunological and rheological parameters. MM was shown to be marked by imbalance of immunobiological reactivity, with the greatest changes being seen in the B cell immunity system. MM is also characterized by marked rheological shifts related to the immunological alterations and underlying the hyperviscosity syndrome and heart failure. Administration of polychemotherapy resulted in a decrease of the count of B lymphocytes, circulating immune complexes; a tendency toward normalization of the rheological blood properties was observed. Introduction of plasmapheresis into the treatment program of the patients noticeably raised the treatment efficacy.
Asunto(s)
Viscosidad Sanguínea , Mieloma Múltiple/inmunología , Adulto , Anciano , Antineoplásicos/administración & dosificación , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Viscosidad Sanguínea/efectos de los fármacos , Enfermedad Crónica , Ciclofosfamida/administración & dosificación , Daunorrubicina/administración & dosificación , Femenino , Insuficiencia Cardíaca/etiología , Humanos , Inmunidad Celular/efectos de los fármacos , Inmunidad Celular/inmunología , Fallo Renal Crónico/etiología , Masculino , Melfalán/administración & dosificación , Persona de Mediana Edad , Mieloma Múltiple/sangre , Mieloma Múltiple/complicaciones , Mieloma Múltiple/tratamiento farmacológico , Compuestos de Mostaza Nitrogenada/administración & dosificación , Prednisolona/administración & dosificación , Vincristina/administración & dosificaciónRESUMEN
In patients with purulent peritonitis, the severe immunodepression and suppression of proliferative activity of stem elements of hemopoietic tissue stroma were revealed. The effectiveness of the use as an immunomodulator of the preparation "Antilympholin" which has the marked immunostimulating properties is shown.