RESUMEN
Experiments in guinea-pigs have indicated that combined immunization with the mixture of live plague and smallpox vaccines introduced subcutaneously by means of a jet injector are safe and faintly reactogenic. Highly intense immunity, as revealed by serological shifts and by the degree of protection of the vaccinated animals challenge with the virulent cultures of the corresponding infective agents, allows the recommendation that combined subcutaneous immunization against plague and smallpox by means of a jet injector be further studied on humans.
Asunto(s)
Vacuna contra la Peste/administración & dosificación , Peste/prevención & control , Vacuna contra Viruela/administración & dosificación , Viruela/prevención & control , Animales , Cobayas , Inyecciones a Chorro , Inyecciones Subcutáneas , ConejosRESUMEN
Reactogenic properties and survival of the smallpox vaccine virus in the organism of the vaccinated rabbits were studied for the purpose of experimental substantiation of the subcutaneous-jet method of smallpox vaccination; serological shifts were determined, and also the intensity of the immunity created to the intracerebral and intranasal infection with the pathogenic strain of the causative agent was assessed. The results of experiment were confirmed in revaccination of humans pointing to weak reactogenic properties and high immunological efficacy of the subcutaneous-jet method of smallpox vaccination.