Asunto(s)
Hipogonadismo/diagnóstico , Pubertad Tardía/diagnóstico , Maduración Sexual , Adolescente , Niño , Genitales Masculinos/anomalías , Genitales Masculinos/crecimiento & desarrollo , Humanos , Hipogonadismo/etiología , Hipogonadismo/fisiopatología , Masculino , Obesidad , Pubertad Tardía/etiología , Pubertad Tardía/fisiopatología , SíndromeRESUMEN
RIA tests to determine the blood levels of gonadotropins, prolactin and different fractions of androgens have shown that the time course of the endogenous level of gonadotropins and androgens in boys aged 9 to 16 with Il-III degree of obesity without clinical signs of disturbed puberty is of the same type as that in healthy boys. However much lower concentrations of testosterone and FSH with a high level of LH and dehydroepiandrosterone were noted in the former. A single administration of chorionic gonadotropin has shown that in normal puberty first develops a mechanism of rapid excretion of testosterone into blood with its maximum concentration in 24-48 h, followed by the development of a mechanism of long-term activation of androgenesis at later stages of puberty. Obese boys with delayed puberty after the type of adiposogenital dystrophy or the syndrome of wrong puberty, demonstrate a more marked blood level of testosterone and FSH than in normal puberty. The clinical level of delayed puberty is determined by the peculiarities of the hypothalamohypophyseal system: the syndrome of wrong puberty is characterized by a sharp rise of adrenal androgenesis leading to premature pubarche, a decrease in the sensitivity of gonads to LH with a simultaneous rise of its blood concentration. Moderate activation of androgenesis in the adrenal glands was observed in false adiposogenital dystrophy, the prepubertal level of LH secretion being preserved.
Asunto(s)
Obesidad/complicaciones , Pubertad Tardía/etiología , Adolescente , Androstenodiona/sangre , Niño , Deshidroepiandrosterona/sangre , Hormona Folículo Estimulante/sangre , Humanos , Enfermedades Hipotalámicas/sangre , Enfermedades Hipotalámicas/diagnóstico , Enfermedades Hipotalámicas/etiología , Sistema Hipotálamo-Hipofisario/fisiopatología , Hormona Luteinizante/sangre , Masculino , Obesidad/sangre , Prolactina/sangre , Pubertad Tardía/sangre , Pubertad Tardía/diagnóstico , Testículo/fisiopatología , Testosterona/sangreAsunto(s)
Gonadotropina Coriónica/administración & dosificación , Criptorquidismo/tratamiento farmacológico , Hormona Liberadora de Gonadotropina/administración & dosificación , Menotropinas/administración & dosificación , Niño , Preescolar , Criptorquidismo/sangre , Criptorquidismo/etiología , Esquema de Medicación , Hormona Folículo Estimulante/sangre , Hormona Folículo Estimulante/deficiencia , Hormonas/administración & dosificación , Humanos , MasculinoRESUMEN
A total of 46 boys aged 11 to 13 with the abnormal puberty syndrome were examined. The authors assessed various methods of correction of delayed puberty by the time course of anthropometric and genitometric indices and blood testosterone, LH and FSH levels 1 year after the initiation of treatment, at the age of 14 to 16 and 17 to 19. The ejaculate composition of 12 adolescents over 17 was examined. In 3/4 of the adolescents the indices of physical development and pubescence, blood testosterone and gonadotropic hormone levels achieved physiological values by the age of 14-16, but in 1/4 of the patients delayed puberty with lowered FSH and testosterone levels and raised LH in the blood was noted. The normalization of puberty was noted at the age of 17 to 19 with normal spermatogenesis. The necessity and methods of therapeutic correction of delayed puberty in boys and adolescents with the abnormal puberty syndrome were discussed.
Asunto(s)
Pubertad Tardía/terapia , Maduración Sexual , Adolescente , Envejecimiento/fisiología , Antropometría , Niño , Terapia Combinada/métodos , Hormona Folículo Estimulante/sangre , Genitales Masculinos/anomalías , Humanos , Hormona Luteinizante/sangre , Masculino , Pronóstico , Pubertad Tardía/diagnóstico , Recuento de Espermatozoides , Testosterona/sangreRESUMEN
The blood basal testosterone-, LH-, FSH levels, 17-CS and 17-HOCS excretion with the urine, circadian rhythms of testosterone-, LH- and FSH secretion were studied in 21 boys, aged 11 to 13 years, with abnormal puberty, manifesting in pronounced sexual hirsutism in the presence of infantile testicles. Functional tests, using chorionic gonadotropin, clomiphene citrate and spironolactone, were performed, as well. The blood level of testosterone and the change in its circadian secretion were markedly reduced in all the subjects under examination. 17-CS excretion with the urine was within normal, whereas that of 17-HOCS was increased, indicating the intensified adrenal functional activity. The study of the blood gonadotropic hormone basal level and circadian rhythms, as well as of the hypophyseal functional reserves revealed diverse changes in LH and FSH production, i.e. a high activity of the hypophyseal LH function and low FSH secretion were noted. The pathogenetic mechanisms of disturbed maturation in abnormal puberty are discussed.