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Tramal, the drug produced by the "Grunenthal" firm (FRG) was used in the treatment of 478 patients with malignant neoplasms. In 24.46% patients, the side effects were noted, which were characteristic of the majority of analgetics and didn't threaten the life. The authors recommend to use Tramal for cupping off the pain syndrome at the postoperative period, and in incurable patients as well.

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Changes of cytochemical indices and phagocytic activity of neutrophil granulocytes of the peripheral blood were revealed in patients with cancer of the rectum at different stages of combined treatment. These changes evidence an increase of vascular permeability and catabolism, disorders of energy resources, oxidation-reduction processes and functional activity of granulocytes. The dynamics of changes of cytochemical indices of leucocytes reflect the efficacy of different methods of treatment and prophylaxis of postoperative purulent complications.

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The results of ultra-violet irradiation of the blood in 207 patients after performance of thoracoabdominal operation for cancer of the esophagus and stomach were analysed. The method permits to reduce the incidence of postoperative complications, manifestations of endogenous intoxication, contributes to improvement in metabolic processes, and normalization of the state of the patients.

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The study including 414 patients aged over 60 years suffering lung esophageal, gastric and colorectal cancer was carried out to assess the possibility of preventing postoperative complications. Preoperative preparation, anesthesiologic medication and drug treatment in the early postoperative period included vitamins, eleutherococcus, sodium oxybutyrate, retabolil, splenin, curantyl, heparin, panangin, sulfalen and trichopol. In that group, the overall postoperative complication rate was 1.5 times lower and that of purulent complications, cardiovascular disorders, pneumonia and pancreatitis--2 times lower than those in 642 controls. The duration of postoperative stay in the hospital was shorter and the postoperative lethality tended to decrease. Topical treatment with methylsiloxane-immobilized gentamycin and 5-fluorouracil was shown to prevent development of purulent complications and pancreatitis.

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With the aim of diagnosis of postoperative pancreatitis in 88 oncologic patients operated on for malignant tumors of the upper alimentary canal and pancreatoduodenal zone, including those with trauma or resection of the pancreas, the comparative analysis of significance of different biochemical indices was carried out. A high sensitivity and informative value of measuring a content of the middle molecular mass peptides and components of kallikrein-kinin system with calculation of a toxicity coefficient permit to recommend their use as the additional diagnostic criteria.

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Half-body irradiation at a single dose of 400-800 cGy was delivered to patients with disseminated fast-growing types of lymphomas and large aggregates of tumors and vital dysfunction of the body (the compression syndrome). Active detoxification therapy including heparinization, hemodilution with enforced diuresis and hemosorption was performed to prevent the syndrome of acute tumor lysis and postradiation complications. This treatment modality resulted in the elimination of clinical manifestations of the compression syndrome, normalization of the body homeostasis, a considerable reduction of the volume of tumor aggregates on a short-term basis, entering the patients into a curable state; the 5-year follow-up results were evaluated.

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Polychemotherapy supplemented by short-time artificial hyperglycemia was carried out in 54 patients with advanced ovarian cancer. For detoxication drugs were used in 27 patients and hemosorption in 27 patients. It was found that hemosorption produced a more detoxifying effect, reduces the frequency of severe complications and allows to improve long-term results.

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Enterosorption as component of preoperative preparation of patients with cancer-induced mechanical jaundice assured subsidence of intoxication, improvement in hepatic and renal functions, better postoperative course, lower rates of purulent and other postoperative complications and lower postoperative lethality.

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1 day after intensive irradiation of cancer patients chemiluminescent (CL) signal of blood sera is considerably enhanced. Hemoperfusion (HP) decreases it by 62%, with the following slight increase in CL intensity. 42-47% increase in electrokinetic erythrocyte potential registered in patients after HP, as well as a certain decrease in blood viscosity may be considered as an indirect explanation of the mechanism of triboluminescence of human blood during HP.

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The rate and pattern of primary postoperative cardiovascular complications were studied in 7,986 cancer patients who underwent thoracoabdominal surgery. The complication rate was 2.99%. The lethality rate in patients with complications was 10.0%. Such factors as the age over 60 years, concomitant heart pathology, surgical manipulation in thoracic cavity and mediastinum alone or in combination with preoperative radiation appeared to enhance the risk for postoperative cardiovascular complications development.

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The study was concerned with postoperative course and dynamics of biochemical indexes for liver function and degree of intoxication in 47 cancer patients suffering mechanical jaundice. The patients received hemosorption preoperatively. Hemosorption was found to significantly increase the efficacy of detoxifying therapy and to contribute to prevention of postoperative complications and lethality.

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Hemosorption was used in complex treatment of postoperative diffuse peritonitis in 69 cancer patients. A pronounced detoxicating effect manifested itself in removal of toxic metabolites from blood matched by an improvement in liver, kidney and cardiovascular function and blood rheologic properties. As a result, lethality rate fell to as low as 69.6% versus 88% in a group of 73 patients in whom the procedure was not used.

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