RESUMEN
It was shown that hen egg-white lysozyme (LM) in the dose 100 mg/kg under the daily intragastral use slightly inhibited tumor grown or did not influence significantly upon it and did not change antitumor activity of cyclophosphamide. When used at mice C57Bl/6J with the transplanted ascitic or solid T-cell lymphoma EL4 (syngeneic system). On model of the same tumors in ascitic form at mice-hybrids (C57Bl/6J x DBA2)F1 (semisingeneic system) LM significantly potentiates antitumor activity of cyclophosphamide, though it had no effect on the rate of tumor growth. Potentiation of the effect of cyclophosphamide revealed itself in more slow development of ascite, increased mean life-span and the overall survival, appearance of completely cured animals. Our clinic-laboratory studies have revealed a sharp deficit of endogenic lysozyme in the blood serum of leukemic patients and extremely low lysozyme content in lavage liquid, from leukemic patients, with pneumonia. These data suggest that LM can be useful as a food additive in the complex treatment of oncological patients for enhancing antineoplastic chemotherapy efficacy.
Asunto(s)
Antineoplásicos Alquilantes/farmacología , Ciclofosfamida/farmacología , Linfoma/patología , Muramidasa/farmacología , Animales , División Celular/efectos de los fármacos , Ratones , Ratones Endogámicos C57BL , Ratones Endogámicos DBAAsunto(s)
Fenómenos Fisiológicos Nutricionales Infantiles , Industria de Procesamiento de Alimentos/tendencias , Prioridades en Salud/tendencias , Fenómenos Fisiológicos Nutricionales del Lactante , Desarrollo de Programa , Preescolar , Humanos , Lactante , Alimentos Infantiles , Recién Nacido , Federación de RusiaRESUMEN
The ten-cells device for modelling of ferment hydrolysis of food proteins by acid basic proteases of human alimentary canal is described. The new procedure for the calculation of quantitative characteristic of proteins digestion "in vitro" is presented.
Asunto(s)
Biotecnología/instrumentación , Proteínas en la Dieta , Digestión , Proteínas en la Dieta/metabolismo , Endopeptidasas/metabolismo , Humanos , Hidrólisis , Técnicas In Vitro , Modelos BiológicosRESUMEN
Paste "Zdorovie", a product with high content of protein and assimilable iron, developed at the Moscow Institute of Applied Biotechnology, has been proved to be effective in the combined antianemia therapy. Improved hemograms and biochemical parameters were recorded in 60 pregnant women and nursing mothers suffering from iron-deficiency anemia (IDA). The data obtained have permitted the authors to recommend paste "Zdorovie" for combined treatment of IDA in pregnant women and to consider it promising in prevention of IDA in nursing mothers.