RESUMEN
OBJECTIVES: This study was undertaken to characterize the neuroinfection profile in a tertiary neurological ward. INTRODUCTION: Neuroinfection is a worldwide concern and bacterial meningitis, tetanus and cerebral malaria have been reported as the commonest causes in developing countries. METHODS: From 1999 to 2007, all patients admitted to the Neurology Ward of Hospital das Clínicas, São Paulo University School of Medicine because of neuroinfection had their medical records reviewed. Age, gender, immunological status, neurological syndrome at presentation, infectious agent and clinical outcome were recorded. RESULTS: Three hundred and seventy four cases of neuroinfectious diseases accounted for 4.2% of ward admissions and the identification of infectious agent was successful in 81% of cases. Mean age was 40.5 + 13.4 years, 63.8% were male, 19.7% were immunocompromised patients and meningoencephalitis was the most common clinical presentation despite infectious agent. Viruses and bacteria were equally responsible for 29.4% of neuroinfectious diseases; parasitic, fungal and prion infections accounted for 28%, 9.6% and 3.5% respectively. Human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV1), Mycobacterium tuberculosis, Treponema pallidum, Taenia solium, Schistosoma mansoni, Cryptococcus neoformans and Histoplasma capsulatum were the more common infectious pathogens in the patients. Infection mortality rate was 14.2%, of which 62.3% occurred in immunocompetent patients. CONCLUSION: Our institution appeared to share some results with developed and developing countries. Comparison with literature may be considered as quality control to health assistance.
Asunto(s)
Enfermedades del Sistema Nervioso Central/epidemiología , Enfermedades Transmisibles/epidemiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Infecciones Bacterianas/epidemiología , Brasil/epidemiología , Femenino , Hospitales de Enseñanza , Humanos , Masculino , Persona de Mediana Edad , Micosis/epidemiología , Enfermedades Parasitarias , Estudios Retrospectivos , Virosis/epidemiología , Adulto JovenRESUMEN
OBJECTIVES: This study was undertaken to characterize the neuroinfection profile in a tertiary neurological ward. INTRODUCTION: Neuroinfection is a worldwide concern and bacterial meningitis, tetanus and cerebral malaria have been reported as the commonest causes in developing countries. METHODS: From 1999 to 2007, all patients admitted to the Neurology Ward of Hospital das Clínicas, São Paulo University School of Medicine because of neuroinfection had their medical records reviewed. Age, gender, immunological status, neurological syndrome at presentation, infectious agent and clinical outcome were recorded. RESULTS: Three hundred and seventy four cases of neuroinfectious diseases accounted for 4.2 percent of ward admissions and the identification of infectious agent was successful in 81 percent of cases. Mean age was 40.5 + 13.4 years, 63.8 percent were male, 19.7 percent were immunocompromised patients and meningoencephalitis was the most common clinical presentation despite infectious agent. Viruses and bacteria were equally responsible for 29.4 percent of neuroinfectious diseases; parasitic, fungal and prion infections accounted for 28 percent, 9.6 percent and 3.5 percent respectively. Human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV1), Mycobacterium tuberculosis, Treponema pallidum, Taenia solium, Schistosoma mansoni, Cryptococcus neoformans and Histoplasma capsulatum were the more common infectious pathogens in the patients. Infection mortality rate was 14.2 percent, of which 62.3 percent occurred in immunocompetent patients. CONCLUSION: Our institution appeared to share some results with developed and developing countries. Comparison with literature may be considered as quality control to health assistance.
Asunto(s)
Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Adulto Joven , Enfermedades del Sistema Nervioso Central/epidemiología , Enfermedades Transmisibles/epidemiología , Infecciones Bacterianas/epidemiología , Brasil/epidemiología , Hospitales de Enseñanza , Micosis/epidemiología , Enfermedades Parasitarias , Estudios Retrospectivos , Virosis/epidemiologíaRESUMEN
Systemic inflammatory response syndrome (SIRS) is a medical condition in which the all-organ microcirculation is affected including nervous system. We describe neurological findings in 64 patients with SIRS at Hospital das Clínicas of Sao Paulo University School of Medicine; 45.3% were male and 54.7% female; their age ranged from 16 to 95 years old. SIRS was caused by infection in 68.8% of patients, trauma in 10.9%, burns in 7.8%, and elective surgery in 4.7%. The central nervous system involvement occurred in 56.3% of patients and was characterized as encephalopathy in 75%, seizures in 13.9%, non-epileptic myoclonus in 2.8%, and ischemic stroke in 8.3%. The magnetic resonance imaging, cerebrospinal fluid and electroencephalographic changes were unremarkable in encephalopathic patients. Neuromuscular disorders were diagnosed in 43.7%. Critical ill polyneuropathy was characterized in 57.1%, critical ill myopathy in 32.1%, demyelinating neuropathy in 7.2%, and pure motor neuropathy in 3.6%. Nerve and muscle pathological studies dismissed inflammatory abnormalities. The identification of these conditions has important economic implications and may change the critically ill patients' prognosis.
Asunto(s)
Enfermedades del Sistema Nervioso/epidemiología , Sistema Nervioso/fisiopatología , Síndrome de Respuesta Inflamatoria Sistémica/epidemiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Isquemia Encefálica/epidemiología , Isquemia Encefálica/fisiopatología , Sistema Nervioso Central/patología , Sistema Nervioso Central/fisiopatología , Comorbilidad , Encefalitis/epidemiología , Encefalitis/fisiopatología , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Mioclonía/epidemiología , Mioclonía/fisiopatología , Sistema Nervioso/patología , Enfermedades del Sistema Nervioso/fisiopatología , Nervios Periféricos/patología , Nervios Periféricos/fisiopatología , Polineuropatías/epidemiología , Polineuropatías/fisiopatología , Polirradiculoneuropatía/epidemiología , Polirradiculoneuropatía/fisiopatología , Síndrome de Respuesta Inflamatoria Sistémica/fisiopatologíaRESUMEN
We report an autosomal recessive neurodegenerative disorder in 25 white members from a large inbred Brazilian family, 22 of whom were evaluated clinically. This condition is characterized by (1) subnormal vision secondary to apparently nonprogressive congenital optic atrophy; (2) onset of progressive spastic paraplegia in infancy; (3) onset of progressive motor and sensory axonal neuropathy in late childhood/early adolescence; (4) dysarthria starting in the third decade of life; (5) exacerbated acoustic startle response; and (6) progressive joint contractures and spine deformities. Motor handicap was severe, and all patients were wheelchair bound after 15 years old. We performed a genome-wide screen including 25 affected individuals and 49 of their unaffected relatives. Linkage was detected at 11q13 region with a maximum logarithm of odds score of +14.43, obtained with marker D11S1883. The candidate region, which lies between D11S1908 and D11S1889, encompasses approximately 4.8Mb and has more than 100 genes and expressed sequences. We propose the acronym SPOAN (spastic paraplegia, optic atrophy, and neuropathy) for this complex syndrome.
Asunto(s)
Cromosomas Humanos Par 11/genética , Neuropatía Hereditaria Motora y Sensorial/genética , Atrofias Ópticas Hereditarias/genética , Paraplejía/genética , Anomalías Múltiples/genética , Adolescente , Adulto , Edad de Inicio , Brasil , Niño , Mapeo Cromosómico , ADN/genética , Progresión de la Enfermedad , Disartria/genética , Femenino , Ligamiento Genético/genética , Humanos , Articulaciones/anomalías , Masculino , Repeticiones de Microsatélite , Persona de Mediana Edad , Linaje , Reflejo de Sobresalto/fisiología , Columna Vertebral/anomalíasRESUMEN
O comprometimento do sistema nervoso periférico é frequente nas vasculites sistêmicas e contribui decisivamente para o diagnóstico. Oito pacientes foram estudados: sete do sexo feminino e um do sexo masculino; cinco brancos, dois negros, um amarelo; média de idade de 55,9 anos; quatro com poliarterite nodosa, um com lúpus eritematoso sistêmico, um com artrite reumatóide, um com vasculite isolada do sistema nervoso periférico e um com vasculite livedóide. Todos foram submetidos a terapêutica intravenosa com pulsos mensais de metilprednisolona (1 g/dia/3dias) e ciclofosfamida (1 g/dia). Cinco pacientes melhoraram, dois permaneceram inalterados e um faleceu. A melhora neurológica objetiva ocorreu após o terceiro ou quarto pulso e nos pacientes com menor duraçao da doença.