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Objective:To investigate the effects of Jin's three needles combined with neuromuscular electrical stimulation on electromyography (EMG), muscle strength, and lower limb motor function in patients with hemiplegia after stroke.Methods:A total of 102 patients with hemiplegia after ischemic stroke who received treatment in Dongyang People's Hospital from July 2021 to August 2022 were included in this randomized controlled study. They were divided into a treatment group and a control group ( n = 51 per group) using a random number table method. The treatment group was given Jin's three needles combined with neuromuscular electrical stimulation, and the control group was given neuromuscular electrical stimulation alone. The National Institutes of Health Stroke Scale (NIHSS) was used to assess the degree of neurological impairment. The modified Barthel Index (MBI) score was used to assess a patient's self-care ability. EMG was performed to record myoelectric signals. The Fugl-Meyer Assessment Scale was used to evaluate a patient's lower limb motor function. Manual Muscle Testing was performed to measure a patient's muscle strength. The degree of nerve defect, self-care ability, lower limb motor function, hip flexion muscle strength, knee extensor muscle strength, and ankle dorsalis extensor muscle strength were compared before treatment and after 2 weeks of treatment. Results:After treatment, the NIHSS score in the treatment and control groups significantly decreased compared with those before treatment [(10.14 ± 3.45) points vs. (3.80 ± 1.92) points, (10.10 ± 3.17) points vs. (6.18 ± 2.15) points, t = 17.31, 19.08, both P < 0.05]. After treatment, the NIHSS score in the treatment group was lower than that in the control group ( t = -5.87, P < 0.001). After treatment, the integral EMG values of the tibialis anterior muscle, gastrocnemius muscle, and quadriceps femoris in the treatment and control groups were increased compared with those before treatment [(20.43 ± 5.26) points vs. (48.14 ± 10.41) points, (16.20 ± 2.62) points vs. (24.69 ± 4.07) points, (32.62 ± 3.42) points vs. (43.40 ± 4.69) points; (20.40 ± 5.19) points vs. (35.45 ± 7.41) points, (16.32 ± 2.51) points vs. (20.91 ± 3.45) points, (32.59 ± 3.37) points vs. (37.39 ± 4.06) points, t = -23.79, -16.11, -19.89; -21.92, -10.86, -8.71, all P < 0.05]. After treatment, the integral EMG values of the tibialis anterior muscle, gastrocnemius muscle, and quadriceps femoris in the treatment group were significantly higher than those in the control group ( t = 7.09, 5.05, 6.92, all P < 0.001). After treatment, The Fugl-Meyer Assessment scale score in the treatment and control groups were significantly increased compared with that before treatment [(17.61 ± 8.93) points vs. (27.16 ± 5.84) points, (17.53 ± 7.59) points vs. (22.22 ± 6.66) points, t = -14.64, -10.72, both P < 0.05). After treatment, The Fugl-Meyer Assessment scale score in the treatment group was significantly higher than that in the control group ( t = 3.98, P < 0.001). After treatment, hip flexion muscle strength, knee extensor muscle strength, and ankle dorsalis extensor muscle strength in the treatment and control groups increased compared with those before treatment. After treatment, hip flexion muscle strength, knee extensor muscle strength, and ankle dorsalis extensor muscle strength in the treatment group were significantly higher than those in the control group [(3.75 ± 0.63) grades vs. (3.31 ± 0.65) grades, (3.51 ± 0.67) grades vs. (3.08 ± 0.87) grades, (2.98 ± 0.81) grades vs.(2.35 ± 1.06) grades, t = 3.41, 2.80, and 3.36, all P < 0.05]. Conclusion:Jin's three needles combined with neuromuscular electrical stimulation can improve EMG findings, increase muscle strength, and lower limb motor function in patients with hemiplegia after stroke
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To explore the mediating role of psychological resilience to childhood abuse and binge eating. This study assessed the childhood abuse, binge eating and psychological resilience of 3 453 middle school students in Harbin city, Heilongjiang Province. SPSS PROCESS macro program, combined with Bootstrap method, was employed to explore the mediating effect of psychological resilience. The incidence of middle school students experiencing at least one type of abuse in their childhood was 81.3% (2 807/3 453). Childhood abuse, psychological resilience and binge eating were all significantly different in terms of gender, household registration and whether they were only child (all P values<0.05). There was a significant positive correlation between childhood abuse and binge eating. Psychological resilience was negatively associated with childhood abuse and binge eating. Childhood abuse could not only directly predict the binge eating behavior of adolescents, but also could indirectly affect it via psychological resilience.
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Aim Paclitaxel(PTX)has shown an effect against human cancer. However, serious drawbacks hamper PTX clinical use.Overcoming paclitaxel limi-tations is one of the best approaches to enhance water solubility.Methods In this study,water-soluble pa-clitaxel prodrug was prepared,folic acid-polyethylene glycol-glutamic-paclitaxel (FA-PEG-Glu-PTX ) com-posed of folic acid (FA,target),amino acids (Glu, linker),and polyethylene glycol(PEG)in order to im-prove the solubilization and stability. The chemical structure and physicochemical property of prodrug were measured by LC-MS,solubility,drug release rate to e-valuate the antitumor activity and cytotoxicity of FA-PEG-Glu-PTX.MTT assays were conducted on MDA-MB-231,MCF-7,A549 and HELF cell lines.FA-PEG-Glu-PTX prodrugs were labeled with 5 amino flu-orescence visible fluorescent dye (5 AF ) for fluores-cence microscopy.Results The successful conjugation of FA-PEG-Glu-PTX was confirmed by LC-MS,and had better water solubility,release rate curve.In vitro studies indicated that foliate receptor(FR-α)mediated uptake of PTX-conjugated multi-small molecules carri-ers induced highly targeting ability,and antitumor ac-tivity,as well as reduced side toxicity effects of PTX. Conclusion FA-PEG-Glu-PTX has a good antitumor activity.