RESUMEN
147318 pregnancy outcomes were analyzed in Zhytomyrska Oblast during 2000-2010; the descriptive analysis was performed. The frequency of birth defects was estimated among newborns, still-born babies and abortions due to genetic disorders of a fetus on "clean" and polluted territories. There was an increase of all birth defects on the polluted territories; among newborns it was (26.10 ± 0.80) per thousand and (24.23 ± 0.47) per thousand, p < 0.05; among newborns and still-born babies it was (26.54 ± 0.81) per thousand and (24.78 ± 0.48) per thousand, p < 0.06. The increase in the birth defects of the nervous system was detected: among newborns it was (1.09 ± 0.17) per thousand and (0.75 ± 0.08) per thousand, p < 0.05; among newborns and still-born babies it was (1.22 ± 0.18) per thousand and (0.81 ± 0.09) per thousand, p. < 0.05; among newborns, still-born babies and genetically caused abortions it was 2.76 ± 0.26) per thousand and (2.34 ? 0.15) per thousand, p = 0.165. Χ2 criteria confirmed the difference between the frequency of birth defects on "clean" and polluted territories. Estimation by Bayes did not confirm the hypothesis about the difference between the frequency of birth defects on "clean" and polluted territories. Endocrine diseases were confirmed to be an important factor of the origin of birth defects, which is important for planning pregnancy on both polluted and "clean" territories.
Asunto(s)
Accidente Nuclear de Chernóbil , Anomalías Congénitas/epidemiología , Glándula Tiroides/efectos de la radiación , Aborto Inducido , Contaminación Radiactiva del Aire , Anomalías Congénitas/genética , Anomalías Congénitas/patología , Femenino , Humanos , Recién Nacido , Embarazo , Resultado del Embarazo , Glándula Tiroides/patologíaRESUMEN
In connection with the drastically changed the human environment, including in connection with pollution by mutagenic and teratogenic factors of different origin, the majority of the population, including in Ukraine, is posed in different living conditions in comparison with previous generations. The recognizance of epigenetic impacts and the possibility of their inheritance significantly increased the role of environmental factors in ensuring human health of both present and future generations. There has been proposed the system of assessment of the status and reproduction of the genofond of the population consisting of assessment of the level of natality, determination of the proportion of persons of optimal reproductive age and children, calculation of the frequency and risk of congenital malformations, spontaneous abortions of the first trimester of gestation, infertile marriages, as well as identification of priority risk factors of formation of pathology, analysis of anthropometric parameters of newborns and comparison them with data characterizing the previous generation. The work of the system is based on existing statistical databases, it requires qualitative level diagnostics and the accounting of congenital malformations, as well as creation registries of congenital malformations, spontaneous abortions and infertile marriages.
Asunto(s)
Contaminantes Ambientales/toxicidad , Pool de Genes , Genética de Población/métodos , Indicadores de Salud , Mutágenos/toxicidad , Reproducción , Aborto Espontáneo/epidemiología , Aborto Espontáneo/genética , Anomalías Congénitas/epidemiología , Anomalías Congénitas/genética , Femenino , Humanos , Recién Nacido , Masculino , Dinámica Poblacional , Reproducción/efectos de los fármacos , Reproducción/genética , Ucrania/epidemiologíaRESUMEN
The cytostatic/cytotoxic effects of the maleimide derivative 1-(4-Cl-Benzyl)-3-Cl-4-(CF3-phenylamino)-1H-pyrrol-2,5-dione (MI-1) have been estimated on epithelial derived human cell cultures (Colo 205, MCF-7, and Hela). The anticancer and toxic effects of MI-1 have been investigated on DMH-induced cancer development and normal colon morphology in rats. The results showed that the compound studied has low cytotoxicity but produces a strong antiproliferative effect on cell cultures and partially suppresses colon cancer development in DMH-induced model. The MI-1 effect on normal colon mucosa is insignificant, and no destructive changes have been detected in the intestine of rats. This maleimide derivate can be considered as a promising anticancer drug.