RESUMEN
This study evaluated, by cross-sectional hardness (CSH), enamel maturation at different depths in sound human teeth at different posteruptive ages (12 per age group): unerupted (molars; control), 2-3 years (premolars), 4-10 years (premolars) and >10 years (molars). Cross-sectional Knoop hardness was measured at 10, 30, 50, 70, 90, 110, 220 and 330 mm depth from the surface. The data were subjected to two-way ANOVA followed by Bonferroni's pairwise tests (a = 0.05). The CSH significantly increased with posteruptive age, indicating that the time of exposure in the oral cavity might result in deep enamel maturation.
Asunto(s)
Esmalte Dental/anatomía & histología , Erupción Dental/fisiología , Factores de Edad , Anatomía Transversal , Diente Premolar/anatomía & histología , Niño , Preescolar , Esmalte Dental/crecimiento & desarrollo , Dureza , Humanos , Diente Molar/anatomía & histología , Proyectos Piloto , Diente no Erupcionado/anatomía & histologíaRESUMEN
Determinou-se a taxa de filtração glomerular por meio do EDTA, marcado com 51Cr e com 113mIn, pela técnica de injeção única, em nove equinos, seis machos e três fêmeas com idades de dois a 12 anos. A taxa de filtração glomerular foi calculada a partir da curva de desaparecimento no plasma e do volume de distribuição do radiotraçador, 51Cr-EDTA ou 113mIn-EDTA. O resultado (média±desvio-padrão) foi de 148,80±26,42mL.min-1.100kg. Conclui-se que a medida da taxa de filtração glomerular pelo 51Cr-EDTA ou 113mIn-EDTA, pela técnica de injeção única, elimina o cateterismo vesical e, por sua simplicidade, comodidade, precisão e baixa dose de radiação, pode ser empregada em cavalos como método de escolha em rotina clínica.
The glomerular filtration rate was determined in nine healthy horses, six male and three female, aged two to 12-year-old, by means of 51Cr and 113mIn labeled EDTA single injection technique. The glomerular filtration rate was calculated from the plasma disappearance curve and the volume of distribution of the radiotracer, 51Cr-EDTA or 113mIn-EDTA. The result (mean±standard deviation) was 148.80±26.42mL.min-1.100kg. It is concluded that the measurement of glomerular filtration rate by 51Cr-EDTA or 113mIn-EDTA by single injection technique eliminates the bladder catheterization, and for its simplicity, convenience, accuracy, and low dose of radiation, can be used in horses as a method of choice in clinical routine.
Asunto(s)
Animales , Masculino , Femenino , Cromo , Ácido Edético , Equidae , Tasa de Filtración GlomerularRESUMEN
Determinou-se a taxa de filtração glomerular por meio do EDTA, marcado com 51Cr e com 113mIn, pela técnica de injeção única, em nove equinos, seis machos e três fêmeas com idades de dois a 12 anos. A taxa de filtração glomerular foi calculada a partir da curva de desaparecimento no plasma e do volume de distribuição do radiotraçador, 51Cr-EDTA ou 113mIn-EDTA. O resultado (média±desvio-padrão) foi de 148,80±26,42mL.min-1.100kg. Conclui-se que a medida da taxa de filtração glomerular pelo 51Cr-EDTA ou 113mIn-EDTA, pela técnica de injeção única, elimina o cateterismo vesical e, por sua simplicidade, comodidade, precisão e baixa dose de radiação, pode ser empregada em cavalos como método de escolha em rotina clínica.(AU)
The glomerular filtration rate was determined in nine healthy horses, six male and three female, aged two to 12-year-old, by means of 51Cr and 113mIn labeled EDTA single injection technique. The glomerular filtration rate was calculated from the plasma disappearance curve and the volume of distribution of the radiotracer, 51Cr-EDTA or 113mIn-EDTA. The result (mean±standard deviation) was 148.80±26.42mL.min-1.100kg. It is concluded that the measurement of glomerular filtration rate by 51Cr-EDTA or 113mIn-EDTA by single injection technique eliminates the bladder catheterization, and for its simplicity, convenience, accuracy, and low dose of radiation, can be used in horses as a method of choice in clinical routine.(AU)
Asunto(s)
Animales , Masculino , Femenino , Tasa de Filtración Glomerular , Ácido Edético , Cromo , EquidaeRESUMEN
The clinical manifestations of neurocysticercosis (NC) are varied and depend on the number and location of cysts, as well as on the host immune response. Symptoms usually occur in NC when cysticerci enter a degenerative course associated with an inflammatory response. The expression of brain damage markers may be expected to increase during this phase. S100B is a calcium-binding protein produced and released predominantly by astrocytes that has been used as a marker of reactive gliosis and astrocytic death in many pathological conditions. The aim of the present study was to investigate the levels of S100B in patients in different phases of NC evolution. Cerebrospinal fluid and serum S100B concentrations were measured in 25 patients with NC: 14 patients with degenerative cysts (D), 8 patients with viable cysts (V) and 3 patients with inactive cysts. All NC patients, except 1, had five or less cysts. In most of them, symptoms had been present for at least 1 month before sample collection. Samples from 8 normal controls (C) were also assayed. The albumin quotient was used to estimate the blood-brain barrier permeability. There were no significant differences in serum (P = 0.5) or cerebrospinal fluid (P = 0.91) S100B levels among the V, D, and C groups. These findings suggest that parenchymal changes associated with a relatively small number of degenerating cysts probably have a negligible impact on glial tissue.
Asunto(s)
Factores de Crecimiento Nervioso/sangre , Factores de Crecimiento Nervioso/líquido cefalorraquídeo , Neurocisticercosis/sangre , Neurocisticercosis/líquido cefalorraquídeo , Proteínas S100/sangre , Proteínas S100/líquido cefalorraquídeo , Adolescente , Adulto , Anciano , Animales , Biomarcadores/sangre , Biomarcadores/líquido cefalorraquídeo , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Persona de Mediana Edad , Subunidad beta de la Proteína de Unión al Calcio S100RESUMEN
The clinical manifestations of neurocysticercosis (NC) are varied and depend on the number and location of cysts, as well as on the host immune response. Symptoms usually occur in NC when cysticerci enter a degenerative course associated with an inflammatory response. The expression of brain damage markers may be expected to increase during this phase. S100B is a calcium-binding protein produced and released predominantly by astrocytes that has been used as a marker of reactive gliosis and astrocytic death in many pathological conditions. The aim of the present study was to investigate the levels of S100B in patients in different phases of NC evolution. Cerebrospinal fluid and serum S100B concentrations were measured in 25 patients with NC: 14 patients with degenerative cysts (D), 8 patients with viable cysts (V) and 3 patients with inactive cysts. All NC patients, except 1, had five or less cysts. In most of them, symptoms had been present for at least 1 month before sample collection. Samples from 8 normal controls (C) were also assayed. The albumin quotient was used to estimate the blood-brain barrier permeability. There were no significant differences in serum (P = 0.5) or cerebrospinal fluid (P = 0.91) S100B levels among the V, D, and C groups. These findings suggest that parenchymal changes associated with a relatively small number of degenerating cysts probably have a negligible impact on glial tissue.
Asunto(s)
Humanos , Animales , Masculino , Femenino , Adolescente , Adulto , Persona de Mediana Edad , Factores de Crecimiento Nervioso/sangre , Factores de Crecimiento Nervioso/clasificación , Neurocisticercosis/inmunología , /sangre , /clasificación , Biomarcadores/sangre , Biomarcadores/líquido cefalorraquídeo , Estudios de Casos y Controles , Neurocisticercosis/sangre , Neurocisticercosis/clasificaciónRESUMEN
Neuron-specific enolase (NSE) is a glycolytic enzyme present almost exclusively in neurons and neuroendocrine cells. NSE levels in cerebrospinal fluid (CSF) are assumed to be useful to estimate neuronal injury and clinical outcome of patients with serious clinical manifestations such as those observed in stroke, head injury, anoxic encephalopathy, encephalitis, brain metastasis, and status epilepticus. We compared levels of NSE in serum (sNSE) and in CSF (cNSE) among four groups: patients with meningitis (N = 11), patients with encephalic injuries associated with impairment of consciousness (ENC, N = 7), patients with neurocysticercosis (N = 25), and normal subjects (N = 8). Albumin was determined in serum and CSF samples, and the albumin quotient was used to estimate blood-brain barrier permeability. The Glasgow Coma Scale score was calculated at the time of lumbar puncture and the Glasgow Outcome Scale (GOS) score was calculated at the time of patient discharge or death. The ENC group had significantly higher cNSE (P = 0.01) and albumin quotient (P = 0.005), but not sNSE (P = 0.14), levels than the other groups (Kruskal-Wallis test). Patients with lower GOS scores had higher cNSE levels (P = 0.035) than patients with favorable outcomes. Our findings indicate that sNSE is not sensitive enough to detect neuronal damage, but cNSE seems to be reliable for assessing patients with considerable neurological insult and cases with adverse outcome. However, one should be cautious about estimating the severity of neurological status as well as outcome based exclusively on cNSE in a single patient.
Asunto(s)
Persona de Mediana Edad , Humanos , Masculino , Femenino , Adulto , Lesiones Encefálicas , Meningitis , Neurocisticercosis , Fosfopiruvato Hidratasa , Anciano de 80 o más Años , Biomarcadores , Lesiones Encefálicas , Estudios de Casos y Controles , Escala de Coma de Glasgow , Meningitis , Neurocisticercosis , Fosfopiruvato Hidratasa , Estudios Prospectivos , Índice de Severidad de la EnfermedadRESUMEN
Neuron-specific enolase (NSE) is a glycolytic enzyme present almost exclusively in neurons and neuroendocrine cells. NSE levels in cerebrospinal fluid (CSF) are assumed to be useful to estimate neuronal injury and clinical outcome of patients with serious clinical manifestations such as those observed in stroke, head injury, anoxic encephalopathy, encephalitis, brain metastasis, and status epilepticus. We compared levels of NSE in serum (sNSE) and in CSF (cNSE) among four groups: patients with meningitis (N=11), patients with encephalic injuries associated with impairment of consciousness (ENC, N=7), patients with neurocysticercosis (N=25), and normal subjects (N=8). Albumin was determined in serum and CSF samples, and the albumin quotient was used to estimate blood-brain barrier permeability. The Glasgow Coma Scale score was calculated at the time of lumbar puncture and the Glasgow Outcome Scale (GOS) score was calculated at the time of patient discharge or death. The ENC group had significantly higher cNSE (P=0.01) and albumin quotient (P=0.005), but not sNSE (P=0.14), levels than the other groups (Kruskal-Wallis test). Patients with lower GOS scores had higher cNSE levels (P=0.035) than patients with favorable outcomes. Our findings indicate that sNSE is not sensitive enough to detect neuronal damage, but cNSE seems to be reliable for assessing patients with considerable neurological insult and cases with adverse outcome. However, one should be cautious about estimating the severity of neurological status as well as outcome based exclusively on cNSE in a single patient.
Asunto(s)
Lesiones Encefálicas/enzimología , Meningitis/enzimología , Neurocisticercosis/enzimología , Fosfopiruvato Hidratasa/sangre , Fosfopiruvato Hidratasa/líquido cefalorraquídeo , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Biomarcadores/sangre , Biomarcadores/líquido cefalorraquídeo , Lesiones Encefálicas/sangre , Lesiones Encefálicas/líquido cefalorraquídeo , Estudios de Casos y Controles , Femenino , Escala de Coma de Glasgow , Escala de Consecuencias de Glasgow , Humanos , Masculino , Meningitis/sangre , Meningitis/líquido cefalorraquídeo , Persona de Mediana Edad , Neurocisticercosis/sangre , Neurocisticercosis/líquido cefalorraquídeo , Fosfopiruvato Hidratasa/metabolismo , Estudios Prospectivos , Índice de Severidad de la Enfermedad , Estadísticas no ParamétricasRESUMEN
The aim of this study was to evaluate, through histologic examination, the effect of surgical repositioning of intruded dog teeth upon the pulpal and surrounding tissues. Thirty teeth in 10 adult dogs, aged 2-3 years, were used. Fifteen teeth were intruded, surgically repositioned and fixed using orthodontics wire, composite resin, and enamel acid conditioning. All these teeth served as the experimental group. The remaining intruded teeth were not treated (control group). The animals were sacrificed to allow observations at 7, 15, and 30 post-operative days. The maxillary and mandibular arches were removed and processed for histologic exam. Based on the methodology and observed results, we concluded that: pulpal necrosis, external root resorption and ankylosis were common sequelae to severe traumatic intrusion; a careful immediate surgical repositioning of severed intruded permanent tooth with complete root formation has many advantages with few disadvantages.
Asunto(s)
Necrosis de la Pulpa Dental/prevención & control , Resorción Radicular/prevención & control , Anquilosis del Diente/prevención & control , Avulsión de Diente/cirugía , Animales , Necrosis de la Pulpa Dental/etiología , Perros , Ferulas Periodontales , Resorción Radicular/etiología , Anquilosis del Diente/etiología , Avulsión de Diente/complicaciones , Avulsión de Diente/patología , Cicatrización de HeridasRESUMEN
Mice spleen cells were incubated in vitro for 24 h with Pisum sativum agglutinin (PSA). The addition of these supernatants (SN) to macrophage cultures induced the production of nitric oxide (NO) by these cells in a dose-dependent manner. NO release was blocked in the presence of IFN gamma antibodies and partially inhibited by TNF alpha antibodies. The ability of PSA in inducing the production of IFN gamma and TNF alpha by spleen lymphocytes was confirmed assaying these cytokine levels in the SN. Spleen cells stimulated in vitro with PSA were highly activated showing an increased expression of the earlier activation marker, CD69, and a great proliferative response. On the other hand, spleen cells obtained from mice treated with PSA 24 h earlier, did not produce significant levels of IFN gamma or TNF alpha when incubated in vitro and showed a significantly lower proliferation rate when pulsed in vitro with PSA or Concanavalin A (ConA). The lower responsiveness to mitogens was also evident after 48 and 72 h after the treatment in vivo with the lectin. Nevertheless, the flow cytometric analysis of spleen lymphocytes obtained from PSA-treated animals showed a high degree of activation in cells CD3+. There was a decrease in the expression of L-selectin and VLA-4, when compared to controls, in parallel with a significant increase in the expression of CD69 and CD122 (IL-2R) in lymphocytes recovered from PSA-injected animals. The data point to evidence that PSA induces immunomodulatory effects, activating spleen lymphocytes in vivo, which become unresponsive to a second stimulation in vitro.
Asunto(s)
Interferón gamma/biosíntesis , Lectinas/farmacología , Activación de Linfocitos/efectos de los fármacos , Lectinas de Plantas , Factor de Necrosis Tumoral alfa/biosíntesis , Animales , Subgrupos Linfocitarios/efectos de los fármacos , Subgrupos Linfocitarios/inmunología , Activación de Macrófagos/efectos de los fármacos , Activación de Macrófagos/fisiología , Macrófagos Peritoneales/efectos de los fármacos , Macrófagos Peritoneales/metabolismo , Masculino , Ratones , Ratones Endogámicos C57BL , Óxido Nítrico/biosíntesis , Bazo/citología , Bazo/efectos de los fármacos , Bazo/inmunologíaRESUMEN
The effects of two nor-diterpenes, trans-dehydrocrotonin (DCTN) and trans-crotonin (CTN) from Croton cajucara (Euphorbiaceae), on the survival of mice bearing Sarcoma 180 and Ehrlich carcinoma ascitic tumours, on the proliferation of cultured Ehrlich cells and TNF alpha activity were determined. When the mice were treated with 80 and 120 mg/kg of DCTN or 38 mg/kg of 5-FU a significant anti-tumour activity was obtained (%T/C of 128-140). The cytotoxicity against Ehrlich carcinoma was 16 microM for DCTN and CTN whereas the flavonoid quercetin was cytotoxic at 44 microM in 48 h cell culture. No apoptosis was seen on in vitro electrophoresis of DNA extracted from the tumour cells treated with DCTN and CTN. A significant TNF alpha activity was detected in Ehrlich tumour-bearing mice treated with DCTN suggesting an enhanced immune function.
Asunto(s)
Antineoplásicos Fitogénicos/farmacología , Diterpenos de Tipo Clerodano , Diterpenos/farmacología , Euphorbiaceae/química , Plantas Medicinales/química , Animales , Antineoplásicos Fitogénicos/aislamiento & purificación , Carcinoma de Ehrlich/metabolismo , Carcinoma de Ehrlich/patología , Diterpenos/aislamiento & purificación , Ensayos de Selección de Medicamentos Antitumorales , Femenino , Ratones , Células Tumorales Cultivadas , Factor de Necrosis Tumoral alfa/biosíntesisRESUMEN
Symptoms of coffee leaf scorch (CLS) appear on young flushes of field plants as large marginal and apical scorched areas on recently mature leaves. Affected leaves drop, shoot growth is stunted, and apical leaves are small and chlorotic. Symptoms may progress to shoot dieback. Only scorched leaves which could not be related to other known agents consistently contained bacteria and bacterial agglomerates when observed with light microscopy. Only plants with these symptoms were positive in enzyme-linked immunosorbent assay (ELISA) tests using antiserum to Xylella fastidiosa Wells et al. The bacterium Xylella fastidiosa Wells et al. was isolated in November 1995 from coffee (Coffea arabica) leaves with scorch symptoms on supplemented periwinkle wilt medium. Colonies were circular, dome-shaped, white, and 0.5 to 1.5 mm in diameter. Two of 10 young coffee seedlings stem-inoculated with a suspension of the isolated X. fastidiosa in January 1996 showed leaf scorch symptoms 3 to 5 months later, contained bacteria in xylem extracts, and reacted positively in ELISA using antiserum to the citrus variegated chlorosis (CVC) strain of X. fastidiosa. ELISA-positive bacteria were reisolated from this plant. None of the symptomless plants, including controls, revealed bacteria on microscopic examinations, ELISA, or isolation attempts. Antisera developed against cultured bacteria from both CLS and CVC plants reacted positively against plant extracts of both diseases in dot immunobinding assays (DIBA). The level of detection was about 5 × 105 bacteria ml-1 for both homologous and heterologous reactions. The polymerase chain reaction amplification products produced by CLS and CVC strains of X. fastidiosa were indistinguishable. Geographical distribution of these strains is not the same. CLS is widespread and usually occurs if coffee is adjacent to CVC-affected citrus. However, CVC does not always occur when citrus is grown adjacent to CLS-affected coffee. The bacteria are closely related, if not identical.
RESUMEN
INTRODUCTION: Moyamoya disease was first believed to be confined to Japan, but over the years it has been reported all over the world. We report seven cases from the University Hospital of the Faculty of Medicine of Ribeirão Preto, University of São Paulo with a review of the previously described cases in Brazil. MATERIAL AND METHODS: The diagnosis was based on the diagnostic criteria of the Research Committee on Spontaneous Occlusion of the Circle of Willis. RESULTS: Five patients presented ischemic and two hemorrhagic events. The meta-analysis of the six cases previously described in Brazil showed that only two were true moyamoya disease according to the diagnostic criteria. CONCLUSION: We can assume that the real frequency of moyamoya disease has been underestimated in Brazil.
Asunto(s)
Angiografía Cerebral , Círculo Arterial Cerebral , Enfermedad de Moyamoya/epidemiología , Adolescente , Adulto , Brasil/epidemiología , Niño , Femenino , Estudios de Seguimiento , Humanos , Lactante , Masculino , Persona de Mediana Edad , Enfermedad de Moyamoya/diagnóstico , Estudios ProspectivosRESUMEN
Pulpal and periodontal tissues of immature incisors of 10 dogs were radiographically and histopathologically evaluated immediately, 7, 15, 30 and 60 days after experimental intrusion induced by mechanical blows. Forty upper central and mesial lateral incisors showing incomplete root formation on radiographs were submitted to intrusive force. After the observation periods, the dogs were killed, two at a time. The hemi-maxilas were removed and processed for histopathologic examination. The traumatized teeth showed accelerated apical formation with reduced radicular length. Pulpal vitality was maintained and the subjacent tissues did not present irreversible changes. All traumatized teeth re-erupted spontaneously.
Asunto(s)
Pulpa Dental/fisiopatología , Incisivo/lesiones , Periodoncio/fisiopatología , Avulsión de Diente/fisiopatología , Raíz del Diente/crecimiento & desarrollo , Animales , Pulpa Dental/lesiones , Perros , Periodoncio/lesiones , Avulsión de Diente/complicaciones , Erupción Dental , Fracturas de los Dientes/etiología , Fracturas de los Dientes/fisiopatología , Raíz del Diente/lesionesRESUMEN
Este estudo avalia a evoluçäo da sensibilidade in vitro do Plasmodium falciparum em uma área de prospecçäo de ouro no Estado do Amapá no período de 1983 a 1990. Foram efetuados 75 testes para cloroquina e quinino, 74 para amodiaquina e 76 para nefloquina. Os resultados revelaram 81 por cento de resistência à cloroquina e 27 por cento para a amodiaquina, enquanto que para quinino e mefloquina näo foram evidenciadas cepas resistentes. Contudo, para estas duas últimas drogas identificou-se uma crescente perda da sensibilidade ao longo do tempo. Aparentemente observa-se uma associaçäo entre resistência à cloroquina e a diminuiçäo da sensibilidade ao quinino
Asunto(s)
Animales , Antimaláricos/antagonistas & inhibidores , Oro , Minería , Plasmodium falciparum/efectos de los fármacos , Brasil , Distribución de Chi-Cuadrado , Relación Dosis-Respuesta a Droga , Resistencia a MedicamentosRESUMEN
This study evaluates the sensitivity of P. falciparum in vitro to antimalarial drugs in an area of gold mining exploration in Amapá State during the period of 1983 to 1990. The following tests were done, 75 in vitro studies with chloroquine and quinine, 74 with amodiaquine and 76 with mefloquine. The results showed 81% of resistance to chloroquine and 27% to amodiaquine while resistant strains to quinine and mefloquine were found. Also for these two quinolinomethanols a loss of sensitivity was noticed in the period of study. An association between resistance to chloroquine and decrease of sensitivity to quinine was also evident with the same strains.
Asunto(s)
Antimaláricos/antagonistas & inhibidores , Oro , Minería , Plasmodium falciparum/efectos de los fármacos , Animales , Brasil , Distribución de Chi-Cuadrado , Relación Dosis-Respuesta a Droga , Resistencia a MedicamentosRESUMEN
O virus da hepatite B é de distribuiçäo universal. Calcula-se que 300 milhöes de indivíduos, em escala mundial, estao cronicamente contaminados pelo mesmo. A transmissäo mae-filho do vírus da hepatite B, que ocorre durante o parto, a chamada transmissäo perinatal, representa fonte muito importante de disseminaçao da infecçäo, principalmente naquelas regiöes em que é alta a endemicidade do HVB. Também é bem sabido que quanto mais precoce for a contaminaçäo com o vírus B, maiores seräo as chances de cronificaçäo do processo. Conseqüentemente, a identificaçäo de mäes AgHBs positivas e administraçäo de HBIG e vacina aos seus recém-nascidos säo altamente recomendadas.
Asunto(s)
Humanos , Femenino , Embarazo , Recién Nacido , Lactante , Hepatitis B/transmisión , Transmisión Vertical de Enfermedad Infecciosa , Vacunas contra Hepatitis B , Hepatitis B/epidemiología , PrevalenciaRESUMEN
Nas complicaçöes da diabetes mellitus pode estar incluido o comprometimento da inervaçäo esofagiana, levando a distúrbios motores do esôfago, mesmo em fases näo sintomáticas. Tendo em vista a simplicidade e a sensibilidade do método cintilográfico no estudo da motilidade esofagiana, os autores propuseram a comparar o tempo de trânsito esofagiano com radionuclídeo em pacientes portadores de diabetes mellitus e em individuos normais. Foram estudados 33 pacientes diabéticos e 26 controles, sendo divididos em grupo A (dependente de insulina) e B (näo dependentes). O estudo mostrou que as alteraçöes no tempo de trânsito esofagiano predominam nos grupos diabéticos näo dependentes de insulina, näo havendo relaçäo com o tempo de duraçäo da doença. No grupo dependente, as anormalidades encontradas tiveram relaçäo com o tempo de doença
Asunto(s)
Humanos , Femenino , Masculino , Adulto , Diabetes Mellitus/complicaciones , Esófago , Trastornos del Movimiento/diagnóstico , Radioisótopos , BrasilAsunto(s)
Inserción Epitelial/efectos de los fármacos , Ligamento Periodontal/efectos de los fármacos , Periodoncio/efectos de los fármacos , Reimplante Dental/métodos , Cicatrización de Heridas , Animales , Citratos/farmacología , Ácido Cítrico , Perros , Tratamiento del Conducto Radicular , Hipoclorito de Sodio/farmacologíaRESUMEN
The authors describe by the first time in the literature a patient with congenital hepatic fibrosis and Caroli's disease complicated by spontaneous bacterial peritonitis. The possible routes of ascitic infection are discussed.