RESUMEN
The aim of the paper is to present a case of self-poisoning with paracetamol, overdosed just before a delivery. A 21-year-old woman was admitted to Obstetric and Gynecology Ward of local hospital in the second stage of physiological delivery, more than 6 hours after she had ingested 19 g of acetaminophen for self-poisoning. She delivered a normal infant weighing 3520 g who had Apgar scores of 10, and then both infant and mother were sent in an emergency ambulance to the nearest poison centre. Blood samples for toxicological examination were taken on admission to toxicological intensive care unit i.e. 11 hours post maternal ingestion. Acetaminophen levels of both patients were above the acetaminophen overdose nomogram line and the antidote treatment, i.v. N-acetylcysteine was administered according to the protocol: the mother within 11 hours post-ingestion and approximately 4 hours after a delivery; the neonate within 11 hours post maternal ingestion and 4 hours of life. Higher paracetamol concentration in the blood of infant compared to the mother's was noted in the first and then control toxicological examination performed within 35 hours post maternal ingestion. Peak maternal aspartate aminotransferase (AST) activity was 326 U/L within 35 hours and alanine aminotransferase (ALT) activity was 262 U/L within 56 hours post-ingestion. The highest neonatal enzyme activity was noted within 11 hours post maternal ingestion of paracetamol, and the elevation was not high. Except moderate anaemia in the mother, no clinical or biochemical symptoms of renal, cardiovascular or CNS injury were stated in the mother or infant. Normalisation in the maternal enzymes activity was stated within 226 hours, while in the neonatal within 58 hours post maternal ingestion. The woman recovered without sequelae and was discharged from hospital on the 11th day following paracetamol overdosing. No evidence of the liver injury was found in the infant either.
Asunto(s)
Acetaminofén/envenenamiento , Enfermedades del Recién Nacido/terapia , Complicaciones del Embarazo/terapia , Efectos Tardíos de la Exposición Prenatal , Acetaminofén/sangre , Adulto , Aspartato Aminotransferasas/sangre , Sobredosis de Droga , Femenino , Humanos , Recién Nacido , Enfermedades del Recién Nacido/sangre , Enfermedades del Recién Nacido/diagnóstico , Embarazo , Complicaciones del Embarazo/sangre , Complicaciones del Embarazo/diagnóstico , Tercer Trimestre del Embarazo , Intento de SuicidioAsunto(s)
Médula Ósea/fisiología , Eritropoyesis/efectos de la radiación , Rayos Ultravioleta , Vías Visuales/fisiología , Animales , Ceguera/sangre , Recuento de Eritrocitos/efectos de la radiación , Cobayas , Masculino , Conejos , Ratas , Transmisión Sináptica/efectos de la radiación , Vías Visuales/efectos de la radiaciónAsunto(s)
Bradiquinina/administración & dosificación , Epinefrina/metabolismo , Histamina/metabolismo , Calicreínas/administración & dosificación , Norepinefrina/metabolismo , Animales , Infusiones Parenterales , Corteza Renal/metabolismo , Pulmón/metabolismo , Masculino , Conejos , Factores de TiempoRESUMEN
The experiments were carried out on 85 rabbits in 15 groups of 5-8 animals in each. The different groups received: 1) ultraviolet radiation once during 45 minutes or daily during 10 minutes for 6 weeks, 2) bradykinin intravenously 10 microgram/kg, 3) kallikrein 5 B.U./kg intramuscularly during 3 weeks. The levels of kinins and kininogen, and the activity of kallikrein and kininases were determined in the blood several times during 24 hours after radiation exposure, and at intervals of two weeks during long-term exposure to radiation. In the same time periods after exposure the basal metabolism and the uptake of oxygen by slices of the kidneys, liver, heart and skin in vitro were determined. Determinations of aerobic metabolism were carried out also after bradykinin injection and at weekly intervals during kallikrein administration. It was found that: 1) after exposure to ultraviolet radiation there was a high rise in the level of kinins and a fall of kininogen, the activity of kininogenases was raised and that of kininases was decreased, while oxygen uptake was reduced moderately; 2) exogenous bradykinin and endogenous kinins reduced oxygen uptake in vivo and in vitro.
Asunto(s)
Metabolismo Basal , Bradiquinina/farmacología , Calicreínas/farmacología , Consumo de Oxígeno , Rayos Ultravioleta , Animales , Metabolismo Basal/efectos de los fármacos , Metabolismo Basal/efectos de la radiación , Depresión Química , Técnicas In Vitro , Consumo de Oxígeno/efectos de los fármacos , Consumo de Oxígeno/efectos de la radiación , ConejosRESUMEN
The experiments were carried out on 54 rabbits in 9 groups of 6 animals each: group I -- controls, groups II, III, IV -- bradykinin i.v., groups V, VI, VII -- Depot-Kallikrein i.m. every other day for 3 weeks, groups VIII and IX -- Traskolan (trasylol) i.v. four times at intervals of 1 or 12 hours. The determined indices of cell-mediated and humoral immunity included: phagocytic activity of the reticuloendothelial system and peripheral blood leucocytes and their leukergic adhesiveness, haemagglutinin and haemolysin levels, serum complement titre, and the number of cells forming rosettes (RFC) or plaques (PFC) in the blood and spleen. These indices were determined 15 minutes, 3 and 24 hours after bradykinin administration, after 1, 2 and 3 weeks of kallikrein administration, and 1 or 12 hours after the last dose of Traskolan. Most determined indices showed always some fall. Only the phagocytic activity of the reticuloendothelial system was moderately increased in all groups, and in the bradykinin group leucocyte phagocytosis was increased slightly while their leukergic reaction was increased very strongly.