RESUMEN

Theranostics based on two-photon excitation of therapeutics in the NIR region is an emerging and powerful tool in cancer therapy since this radiation deeply penetrates healthy biological tissues and produces selective cell death. Aggregates of gold nanoparticles coated with glutathione corona functionalized with the dansyl chromophore (a-DG-AuNPs) were synthesized and found efficient nanodevice for applications in photothermal therapy (PTT). Actually the nanoparticle aggregation enhances the quenching of radiative excitation and the consequent conversion into heat. The a-DG-AuNPs are readily internalized in Hep G2 where the chromophore acts as both antenna and transducer of the NIR radiation under two-photons excitation, determining efficient cell ablation via photothermal effect.

Asunto(s)

Terapia por Luz de Baja Intensidad/métodos , Nanopartículas del Metal/administración & dosificación , Neoplasias/terapia , Terapia Fototérmica/métodos , Nanomedicina Teranóstica/métodos , Animales , Línea Celular Tumoral , Terapia Combinada/instrumentación , Terapia Combinada/métodos , Fluorescencia , Glutatión/química , Oro/química , Humanos , Rayos Infrarrojos/uso terapéutico , Rayos Láser , Terapia por Luz de Baja Intensidad/instrumentación , Nanopartículas del Metal/química , Ratones , Neoplasias/patología , Fosfatidilcolinas/química , Fotones/uso terapéutico , Terapia Fototérmica/instrumentación , Nanomedicina Teranóstica/instrumentación