RESUMEN
Introducción: Los resultados del lupus eritematoso sistémico (LES) en el trasplante renal (TR) a largo plazo son variables. El objetivo de este estudio fue analizar la supervivencia del injerto y del paciente comparándola con la relativa a las glomerulonefritis primarias (GNP). Materiales y métodos: Se compararon 43 pacientes a los que se les había realizado TR con diagnóstico de nefritis lúpica (NL) y 367 con GNP entre enero de 1980 y diciembre de 2014. Se analizó la supervivencia y las causas de pérdida y muerte del injerto y del paciente. Resultados: No hubo diferencias significativas entre las variables analizadas en ambos grupos. La supervivencia del injerto a los 5 años (80% LES vs. 70% GNP) y 10 años (63% LES vs. 55% GNP) y del paciente a los 5 años (90% LES vs. 90% GN) y 10 años (76% LES vs. 79% GN) fueron similares. Ningún injerto se perdió por recidiva de la NL. Conclusiones: Los enfermos con LES son unos candidatos a trasplante similares a los de otras enfermedades renales de etiología inmunológica. No se observó recidiva de la enfermedad en ningún paciente
Introduction: The outcome and prognosis of systemic lupus erythematosus (SLE) in long-term kidney transplantation (KT) is variable. The objective of this study was to analyse the survival of the graft and the patient, comparing rates with a control group (primary glomerulonephritis [PGN]). Materials and methods: Forty-three patients receiving a KT with diagnosis of lupus nephritis (LN) and 367 patients with PGN were compared between January 1980 and December 2014. The survival causes of loss and death of the graft and the patient were analysed. Results: There were no significant differences between the variables analysed. The graft survival at five years (80% SLE vs. 70% PGN) and 10 years (63% SLE vs. 55% PGN) and the patient at 5 years (90% SLE vs. 90% PGN) and 10 years (76% LES vs. 79% PGN) were similar. Not recurrence of LN was observed in any patient. Conclusions: Patients with SLE are similar candidates to KT than that with other immunological kidney diseases. There was no recurrence of the disease in any patient
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Trasplante de Riñón/métodos , Lupus Eritematoso Sistémico/diagnóstico , Pronóstico , Supervivencia de Injerto , Trasplante de Riñón/tendencias , Glomerulonefritis/diagnóstico , Lupus Eritematoso Sistémico/epidemiología , Análisis de Varianza , Terapia de Inmunosupresión , Inhibidores de la CalcineurinaRESUMEN
INTRODUCTION: The outcome and prognosis of systemic lupus erythematosus (SLE) in long-term kidney transplantation (KT) is variable. The objective of this study was to analyse the survival of the graft and the patient, comparing rates with a control group (primary glomerulonephritis [PGN]). MATERIALS AND METHODS: Forty-three patients receiving a KT with diagnosis of lupus nephritis (LN) and 367 patients with PGN were compared between January 1980 and December 2014. The survival causes of loss and death of the graft and the patient were analysed. RESULTS: There were no significant differences between the variables analysed. The graft survival at five years (80% SLE vs. 70% PGN) and 10 years (63% SLE vs. 55% PGN) and the patient at 5 years (90% SLE vs. 90% PGN) and 10 years (76% LES vs. 79% PGN) were similar. Not recurrence of LN was observed in any patient. CONCLUSIONS: Patients with SLE are similar candidates to KT than that with other immunological kidney diseases. There was no recurrence of the disease in any patient.
Asunto(s)
Trasplante de Riñón , Nefritis Lúpica/cirugía , Adulto , Femenino , Glomerulonefritis/mortalidad , Glomerulonefritis/cirugía , Supervivencia de Injerto , Humanos , Nefritis Lúpica/mortalidad , Masculino , Persona de Mediana Edad , Pronóstico , Estudios Retrospectivos , Tasa de Supervivencia , Resultado del TratamientoRESUMEN
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Asunto(s)
Humanos , Masculino , Andrógenos/deficiencia , Testosterona/administración & dosificación , Diálisis Renal/efectos adversos , Insuficiencia Renal Crónica/terapia , Resultado del TratamientoAsunto(s)
Terapia de Reemplazo de Hormonas , Diálisis Renal/efectos adversos , Testosterona/deficiencia , Testosterona/uso terapéutico , Administración Cutánea , Anciano , Anciano de 80 o más Años , Geles , Terapia de Reemplazo de Hormonas/métodos , Humanos , Datos Preliminares , Testosterona/administración & dosificación , Testosterona/sangreRESUMEN
Objetivos: Conocer el estado actual del seguimiento de la función renal realizada a los pacientes tratados con antiinflamatorios no esteroideos (AINE). Material y métodos: Se seleccionaron los pacientes adultos atendidos en un centro de Atención Primaria de la Comunidad de Madrid que recibieron algún AINE por primera vez. Se analizó si durante los 2 meses previos y los 6 posteriores a la prescripción del AINE se conocía la función renal. Resultados: Durante el período de estudio se registraron 42.822 prescripciones. Un total de 8611 figuran como nuevas prescripciones, 482 de las cuales (5,6 %) fueron prescripción de AINE y se realizaron en pacientes mayores de 14 años. Recibieron algún AINE 450 pacientes (64 % mujeres). Ibuprofeno (66,0 %) fue el más frecuentemente prescrito. El grupo de edad con más prescripciones de AINE fue el de 14-45 años. Solo 168 (37,1 %) cuentan con alguna analítica solicitada durante el estudio (68 % mujeres). Antes de recibir AINE, solo en el 14 % (63 pacientes) se conocía el valor de creatinina sérica. Dos pacientes recibieron AINE pese a tener cifras elevadas de creatinina. Tras la prescripción se solicitó creatinina sérica en 129 pacientes (28,7 %). Conclusiones: Se prescribe un número importante de AINE. El más utilizado es el ibuprofeno. Las prescripciones son más frecuentes en mujeres y en personas de entre 14-45 años de edad. El dolor musculoesquelético es la causa principal de esta indicación. Solo en el 14 % de los pacientes a los que se les trató con AINE se conocía el valor de creatinina, que no siempre se tuvo en cuenta a la hora de la prescripción. El control de la función renal tras prescribir AINE fue porcentualmente bajo (AU)
Objectives: To determine the current state of renal function monitoring carried out on patients treated with NSAIDs. Material and Method: We selected patients from a Primary Care Centre who had received NSAIDs for the first time. We checked if renal function was measured and/or controlled 2 months pre/6 months post-NSAID administration in order to assess if patient renal function was known at the time of prescription and afterwards. Results: During the study period, there were 42 822 prescriptions made. Of these, 8611 were new drug prescriptions, of which 482 (5.6%) were NSAIDs in patients older than 14 years of age. A total of 450 patients (64% female) were treated with NSAIDs. Ibuprofen (66.0%) was the most commonly prescribed. NSAIDs were more frequently used in patients between 14-45 years of age. Only 168 (37.1%) patients underwent any analytical tests over the course of the study (68% female). Before prescription, renal function was measured in only 14% of cases (63 patients). Two patients received NSAIDs despite having high serum creatinine levels. During the follow-up, serum creatinine was measured in 129 patients (28.7%). Conclusions: In primary care, NSAIDs represent a substantial percentage of the drugs prescribed (5.6%). Ibuprofen is the most commonly prescribed. NSAIDs are more frequently used in women between 14-45 years. Musculo-skeletal pain is the main indication for prescription. Only 14% of patients receiving these drugs had previously measured levels of serum creatinine. These values are rarely taken into account when prescribing NSAIDs. Control of renal function after NSAID prescription was unusual (AU)
Asunto(s)
Humanos , Antiinflamatorios no Esteroideos/uso terapéutico , Monitoreo de Drogas/métodos , Pruebas de Función Renal/métodos , Atención Primaria de Salud , Prescripciones de Medicamentos/estadística & datos numéricosRESUMEN
OBJECTIVES: To determine the current state of renal function monitoring carried out on patients treated with NSAIDs. MATERIAL AND METHOD: We selected patients from a Primary Care Centre who had received NSAIDs for the first time. We checked if renal function was measured and/or controlled 2 months pre/6 months post-NSAID administration in order to assess if patient renal function was known at the time of prescription and afterwards. RESULTS: During the study period, there were 42 822 prescriptions made. Of these, 8611 were new drug prescriptions, of which 482 (5.6%) were NSAIDs in patients older than 14 years of age. A total of 450 patients (64% female) were treated with NSAIDs. Ibuprofen (66.0%) was the most commonly prescribed. NSAIDs were more frequently used in patients between 14-45 years of age. Only 168 (37.1%) patients underwent any analytical tests over the course of the study (68% female). Before prescription, renal function was measured in only 14% of cases (63 patients). Two patients received NSAIDs despite having high serum creatinine levels. During the follow-up, serum creatinine was measured in 129 patients (28.7%). CONCLUSIONS: In primary care, NSAIDs represent a substantial percentage of the drugs prescribed (5.6%). Ibuprofen is the most commonly prescribed. NSAIDs are more frequently used in women between 14-45 years. Musculo-skeletal pain is the main indication for prescription. Only 14% of patients receiving these drugs had previously measured levels of serum creatinine. These values are rarely taken into account when prescribing NSAIDs. Control of renal function after NSAID prescription was unusual.