RESUMEN
This article reviews the progress made by Chinese scientists in the field of natural products chemistry in 2011. Selected compounds with unique structural features and/or promising bioactivities are described herein on the basis of structural types.
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Productos Biológicos/análisis , Extractos Vegetales/química , Plantas Medicinales/química , China , Estructura MolecularRESUMEN
This article reviews the progresses made by Chinese scientists in the field of natural products chemistry in 2010. Selected compounds with unique structural features and/or promising bioactivities were described herein on the basis of structural types.
Asunto(s)
Productos Biológicos/química , Productos Biológicos/farmacología , China , Humanos , Estructura Molecular , InvestigaciónRESUMEN
Two unprecedented dimeric diterpenoids, with a 2,3-dihydrofuran ring fusing an abietane and a 4,5-seco-abietane diterpene, were isolated from Cunninghamia lanceolata. Their structures were elucidated by spectroscopic measurements, and their absolute configurations were determined by quantum chemical TDDFT ECD calculations, chemical transformations, and Mosher's method. The Mosher method carried out with MPA and MTPA esters of the sterically hindered sec-hydroxyl group gave contradictory results, while MPA afforded the correct absolute configuration.
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Cunninghamia/química , Diterpenos/química , Dimerización , Diterpenos/aislamiento & purificación , Modelos Moleculares , Conformación MolecularRESUMEN
Fifteen limonoids, meliatoosenins E-S (1-15), and 10 known compounds were isolated from the fruits of Melia toosendan. Their structures were elucidated on the basis of extensive spectroscopic methods including DEPT, HSQC, HMBC, (1)H-(1)H COSY, and ROESY experiments. All the compounds were evaluated for antiproliferative activity using A-549 and HL-60 cell lines.
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Antineoplásicos Fitogénicos/aislamiento & purificación , Medicamentos Herbarios Chinos/aislamiento & purificación , Limoninas/aislamiento & purificación , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Medicamentos Herbarios Chinos/química , Medicamentos Herbarios Chinos/farmacología , Frutas/química , Células HL-60 , Humanos , Limoninas/química , Limoninas/farmacología , Melia/química , Estructura Molecular , Resonancia Magnética Nuclear BiomolecularRESUMEN
Pueraria lobata flower is a medicinal herb for treating intoxication, hepatic, and gastrointestinal tract lesions induced by alcohol. This study aims to investigate the isoflavonoid glycosides in P. lobata flowers. Two new isoflavone compounds were isolated from the extract of P. lobata flowers. Their structures were determined to be 5,6,7,4'-tetrahydroxyisoflavone-6,7-di-O-ß-D-glucopyranoside and 5,6,7-trihydroxy-4'-methoxyisoflavone-6,7-di-O-ß-D-glucopyranoside on the basis of spectroscopic means including HR-ESI-MS, UV, IR, ¹H, and ¹³C NMR.
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Medicamentos Herbarios Chinos/química , Glicósidos/aislamiento & purificación , Isoflavonas/aislamiento & purificación , Pueraria/química , Flores/química , Glicósidos/química , Isoflavonas/química , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , EstereoisomerismoRESUMEN
Two new alkaloids, 4'-O-demethylhamatine (1) and ancistrotectoriline C (2), were isolated from the stems and leaves of Ancistrocladus tectorius. These two compounds represent one 5,1'-coupled and one 7,6'-coupled naphthylisoquinoline alkaloid, respectively. Their structures were elucidated by 1D- and 2D-NMR spectra and other spectroscopic studies.
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Alcaloides/química , Isoquinolinas/química , Magnoliopsida/química , Hojas de la Planta/química , Tallos de la Planta/química , Espectroscopía de Resonancia Magnética , Estructura MolecularRESUMEN
Phytochemical investigation on the stem bark and wood of Trigonostemon chinensis led to the isolation of four new dinorditerpenoids, trigonostemons A-D (1, 3, 5, 6), a new phenanthrenone, trigonostemon E (7), and a new bisindole alkaloid, trigonostemon F (8). The structures were established by extensive spectroscopic methods. The absolute configurations of 1-6 were determined by X-ray crystallography, circular dichroism, quantum chemical TDDFT calculations, and chemical transformations. The relative configuration of 8 was confirmed by X-ray diffraction analysis.