RESUMEN
In this work, a Cs2 CO3 -promoted synthetic approach was identified for (hetero)aryl ether synthesis via the C-O coupling of various (hetero)aryl chlorides and alcohols/phenol. To our delight, the reactions could be carried out under transition-metal-free and solvent-free conditions. Moreover, analytical-grade reagents and air atmosphere were readily tolerated. To showcase the practical usefulness of the present protocol, the assembly of a bioactive molecule was facilely realized and the gram-scale production of selected ether products was also efficiently accomplished. In addition, density functional theory (DFT) studies, along with a few mechanistic experiments, were conducted to elucidate a proposed reaction pathway and rationalize the pivotal role of Cs2 CO3 in promoting this process. Hopefully, this work could provide useful information for researchers who are engaging in C-O cross-coupling reactions.
Asunto(s)
Alcoholes , Elementos de Transición , Atmósfera , Catálisis , ÉteresRESUMEN
The "Xiang" in traditional Chinese medicine (TCM) contains various meanings such as phenomena, image and symbols. When we consider it as a thinking mode, "Xiang" permeates into all TCM aspects from natural phenomena, anatomical structures of human tissues to physiological functions as well as pathological manifestations of zang-fu organs. In addition, it may have profound but different connotations. The authors of this article analyzed the "Xiang" in TCM according to the "Xiang" of nature, "Xiang" of zang-organs, "Xiang" of spirit, "Xiang" of pulse (pulse conditions) and "Xiang" of tongue (tongue conditions).