RESUMEN
OBJECTIVES: To identify differences in the mean vitamin D concentrations in samples obtained from a private laboratory in Quito and to explore their relationship with the pre-pandemic and pandemic periods spanning from 2018 to 2022. DESIGN: A combination of an interrupted time series design and a retrospective cross-sectional approach. SETTING AND PARTICIPANTS: The study involved 9285 participants who had their 25-hydroxyvitamin D (25(OH)D) levels tested at a well-known private laboratory in Quito, Ecuador, from 2018 to 2022. PRIMARY AND SECONDARY OUTCOME MEASURES: The 25(OH)D levels were analysed and assessed for correlations with age, and the year the measurements were taken. RESULTS: The mean 25(OH)D level was 27.53 ng/mL (± 14.11). Approximately 68.8% of participants had serum 25(OH)D levels of less than 30 ng/mL, and 0.6% showed potential harm from excess 25(OH)D, with levels over 100 ng/mL. The analysis indicated a significant monthly increase of 0.133 units in 25(OH)D levels (p=0.006). However, the period after March 2020, compared with before, saw a non-significant decrease of 1.605 units in mean 25(OH)D levels (p=0.477). CONCLUSIONS: The study's findings indicate a significant prevalence of 25(OH)D deficiency, underscoring the necessity for preventative measures. However, the increasing trend in high 25(OH)D levels is concerning, emphasising the importance of prudent vitamin D supplement prescriptions and public education against self-medication. For efficient resource allocation and targeting of those with higher risks, it may be advantageous to concentrate vitamin D testing on specific population groups.
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Análisis de Series de Tiempo Interrumpido , Deficiencia de Vitamina D , Vitamina D , Vitamina D/análogos & derivados , Humanos , Ecuador/epidemiología , Estudios Transversales , Vitamina D/sangre , Femenino , Adulto , Masculino , Deficiencia de Vitamina D/epidemiología , Deficiencia de Vitamina D/sangre , Persona de Mediana Edad , Adulto Joven , Adolescente , Estudios Retrospectivos , Anciano , Niño , Preescolar , Ciudades , COVID-19/epidemiología , COVID-19/sangre , LactanteRESUMEN
entre los jóvenes universitarios se ha observado una tolerancia creciente hacia el consumo de drogas, debido entre otros factores a una reducción en la percepción de riesgo, que puede con-tribuir a la normalización del consumo. El objetivo fue analizar la percepción de los estudiantes de unauniversidad pública mexicana sobre la situación y la gravedad del consumo de drogas en su institución mediante diversos indicadores. Materiales y métodos: se analizó la base de datos derivada de la aplica-ción del Cuestionario sobre Consumo de Drogas en Estudiantes Universitarios (codeu-3), en el que partici-paron 19 815 estudiantes; se realizaron comparaciones según sexo y área académica utilizando pruebas de chi-cuadrado y el análisis post hoc de Bonferroni. Resultados: las mujeres indicaron tener una menor percepción de riesgo que los hombres sobre las variables analizadas (percepción de los participantes sobre el consumo de drogas en su facultad, venta y gravedad del consumo de drogas, según sexo y área académica y conductas de docentes y estudiantes que facilitan el consumo de alcohol y la postura de las autoridades universitarias ante estudiantes consumidores, según sexo y área académica). Conclusión: los resultados muestran diferencias en la percepción de hombres y mujeres, así como las diferencias asociadas con la adscripción de los estudiantes en las distintas áreas académicas, por lo que se sugiere profundizar el estudio de estos aspectos.
There is a growing tolerance toward drug use among university students due to a reduction in the perception of risk, which is considered as those judgments or intuitions held regarding the danger of a situation that can contribute to the normalization of consumption. This study aimed to analyze the perception of the students at a Mexican public university toward the situation and seriousness of drug use in the university using various indicators. Materials and methods: The database derived from the application of the Questionnaire on Drug Use in University Students (codeu-2 by its name in Spanish), in which 19,815 students from a Mexican public university participated, was analyzed, and comparisons were made according to gender and academic area using chi-squared tests and Bonferroni's post hocanalysis. Results: Women were reported to have a lower perception of risk than men on the variables analyzed (participants' perception of drug use in their faculty, sale and severity of drug use, according to gender and academic area, and behaviors of teachers and students that facilitate alcohol use and the position of university authorities towards student consumers, according to gender and academic area). Conclusion: The results indicated the importance of studying in greater depth the differences in the perception of men and women, as well as their affiliation in the different academic areas.
tem-se observado entre os jovens universitários uma crescente tolerância ao uso de dro-gas, devido à redução da percepção de risco, que é considerada como aqueles julgamentos ou intuições que se fazem sobre o perigo de uma situação, o que pode contribuir para a normalização do consumo. O objetivo do estudo foi analisar a percepção dos estudantes de uma universidade pública mexicana sobre a situação e a gravidade do uso de drogas em sua instituição por meio de vários indicadores. Materiais e métodos: analisou-se a base de dados derivada da aplicação do Questionário de Uso de Drogas em Estudantes Universitários (codeu-2), do qual participaram 19,815 estudantes; as comparações foram feitas de acordo com o gênero e a área acadêmica por meio de testes de qui-quadrado e análise post hoc de Bonferroni. Resultados: as mulheres relataram menor percepção de risco do que os homens nas variáveis analisadas (percepção dos participantes sobre o uso de drogas na faculdade, venda e gravidade do uso de drogas, por gênero e área acadêmica, e comportamentos de professores e alunos que facilitam o consumo de álcool e a atitude das autoridades universitárias perante estudantes consumidores, de acordo com o gênero e área acadêmica). Conclusão: os resultados mostram diferenças na percepção de homens e mulheres, bem como as diferenças associadas à inserção dos alunos nas diferentes áreas acadêmicas, para o que se sugere aprofundar o estudo desses aspectos.
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Humanos , Postura , Psicotrópicos , Estudiantes , Universidades , Conducta , Actitud , RiesgoRESUMEN
This article presents the use of generalized additive model for location scale and shape (GAMLSS) in the qualitative and quantitative analysis of the relationships between environmental parameters and cyanotoxins in the tropical reservoirs of Colombia. The physicochemical parameters were evaluated on each of the cyanotoxins detected with levels high by ultra-high-performance liquid chromatography coupled to triple quadrupole mass spectrometry. The models showed a relation between cyanotoxins and the nutrients as soluble total Kjeldahl nitrogen (NTK), soluble phosphorus (soluble P), total phosphorus (total P), and nitrates (NO3-), among other nutrients that are necessary for the growth of organisms that produce toxins. This model confirms that the NTK and soluble P variables favor an increase in the concentration of MC-LR and MC-YR cyanotoxins in the Abreo Malpaso reservoir. The variables NO3- and dissolved O2 contribute to a higher concentration of MC-LR, MC-YR, and MC-ADRR cyanotoxins in the Peñol reservoir. Finally, the variable total P favors the increase in the concentration of MC-LR cyanotoxin and the variable dissolved O2 favors the increase in the concentration of cyanotoxin [D-Asp3, (E)-Dhb7] -MC-RR in the Playas reservoir.
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Monitoreo del Ambiente , Microcistinas , Cromatografía Líquida de Alta Presión , Toxinas de Cianobacterias , Microcistinas/análisis , Modelos EstadísticosRESUMEN
INTRODUCTION: Coronary ectasia has a low prevalence in the general population. Its risk factors may differ from those of coronary artery disease. OBJECTIVE: To identify the prevalence of coronary ectasia in patients with acute myocardial infarction (AMI) and cardiovascular risk factors (CVRFs). METHODS: Retrospective, cross-sectional study. Out of 3,254 cardiac catheterizations for AMI during one year, 2,975 had no coronary ectasia. We included 558 patients with coronary ectasia on coronary angiography and, as controls, subjects with similar characteristics except for coronary ectasia, and CVRFs were recorded. Descriptive statistics, bivariate and multivariate analysis were used; odds ratio (OR) was calculated. RESULTS: 279 patients with and without coronary ectasia were studied. The prevalence of coronary ectasia was 8.5 %. The platelet/lymphocyte ratio (PLR) was higher in patients with ectasia than in those without ectasia (p = 0.003). In the bivariate analysis, associated CVRFs were overweight, obesity and diabetes, and in the multivariate analysis, hypercholesterolemia (OR: 3.90; p = 0.0001) and exposure to herbicides (OR: 6.82; p = 0.020). CONCLUSIONS: A high prevalence of coronary ectasia was found, with the main risk factors being a history of herbicide use and hypercholesterolemia. PLR was found to be elevated in these patients. Early detection is important due to its association with acute coronary events.
INTRODUCCIÓN: La ectasia coronaria tiene baja prevalencia en población general, los factores de riesgo pueden diferir de la enfermedad arterial coronaria. OBJETIVO: Identificar la prevalencia de ectasia coronaria en pacientes con infarto agudo de miocardio (IAM) y factores de riesgo cardiovascular (FRCV). MÉTODOS: Estudio retrospectivo, transversal. De 3,254 cateterismos cardiacos por IAM durante un año, 2,975 no presentaron ectasia coronaria. Se incluyeron 558 pacientes clasificados como portadores de ectasia coronaria en coronariografía y controles aquellos con características similares exceptuando la ectasia coronaria y se registraron los FRCV. Empleamos estadística descriptiva, análisis bivariante, multivariante y calculamos el odds ratio (OR). RESULTADOS: Se estudiaron 279 pacientes con y sin ectasia coronaria. La prevalencia de ectasia coronaria fue del 8.5%. El índice plaqueta/linfocito (IPL) se encontró más elevado en pacientes con ectasia que en aquellos sin ectasia (p = 0.003). En el análisis bivariante los FRCV asociados fueron sobrepeso, obesidad y diabetes, y en el multivariante la hipercolesterolemia (OR: 3.90; p = 0.0001) y exposición a herbicidas (OR: 6.82; p = 0.020). CONCLUSIONES: Encontramos alta prevalencia de ectasia coronaria, los principales factores de riesgo fueron el antecedente de uso de herbicidas e hipercolesterolemia. Identificamos el IPL elevado en estos pacientes. Es importante la detección oportuna debido a su asociación con eventos coronarios agudos.
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Enfermedades Cardiovasculares , Infarto del Miocardio , Estudios Transversales , Dilatación Patológica/epidemiología , Factores de Riesgo de Enfermedad Cardiaca , Humanos , Infarto del Miocardio/epidemiología , Estudios Retrospectivos , Factores de RiesgoRESUMEN
In the present work, the degradation of three cyanotoxins from the hepatotoxins group was investigated under laboratory-controlled experiments in water samples. Surface waters spiked with microcystin-LR (MC-LR), nodularin (NOD) and cylindrospermopsin (CYN) were subjected to hydrolysis, chlorination and photo-degradation, under both sunlight (SL) and ultraviolet (UV) radiation. A total of 12 transformation products (TPs) were detected and tentatively identified by liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (LC-QTOF MS). These comprised: 6 chlorination TPs (3 from CYN and 3 from MC-LR, 2 isomers); 4 UV TPs (all from CYN); and 2 sunlight TPs (one isomer from MC-LR and another from NOD). No TPs were observed under hydrolysis conditions. The chemical structures for all TPs were tentatively proposed based on the accurate-mass QTOF MS full-spectra. Analysis of real-world samples collected from the Peñol reservoir (Antioquia, Colombia) revealed the presence of MC-LR and CYN as well as a sunlight TP identified in the laboratory experiments. Data presented in this article will assist further research on TPs potentially formed in future tertiary degradation processes applied for the removal of organic micro-pollutants in water; as well as improving available knowledge on the toxic implications of cyanobacterial toxins TPs in surface waters.
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Toxinas Bacterianas/química , Microcistinas/química , Péptidos Cíclicos/química , Uracilo/análogos & derivados , Contaminantes Químicos del Agua/química , Alcaloides , Toxinas Bacterianas/análisis , Cromatografía Liquida/métodos , Colombia , Toxinas de Cianobacterias , Halogenación , Hidrólisis , Toxinas Marinas , Espectrometría de Masas , Microcistinas/análisis , Péptidos Cíclicos/análisis , Luz Solar , Rayos Ultravioleta , Uracilo/análisis , Uracilo/química , Contaminantes Químicos del Agua/análisisRESUMEN
Human rhinovirus (HRV) is a leading cause of acute respiratory infection (ARI) in young children and infants worldwide and has a high impact on morbidity and mortality in this population. Initially, HRV was classified into two species: HRV-A and HRV-B. Recently, a species called HRV-C and possibly another species, HRV-D, were identified. In Mexico, there is little information about the role of HRV as a cause of ARI, and the presence and importance of species such as HRV-C are not known. The aim of this study was to determine the clinical characteristics and genetic variability of HRV in Mexican children. Genetic characterization was carried out by phylogenetic analysis of the 5'-nontranslated region (5'-NTR) of the HRV genome. The results show that the newly identified HRV-C is circulating in Mexican children more frequently than HRV-B but not as frequently as HRV-A, which was the most frequent species. Most of the cases of the three species of HRV were in children under 2 years of age, and all species were associated with very mild and moderate ARI.