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OBJECTIVES: to evaluate the effect of guided imagery relaxation through virtual reality on anxiety in women with cervical cancer undergoing radiochemotherapy. METHODS: randomized, non-blinded, single-center clinical trial conducted at a cancer reference hospital. 52 women participated, with randomized allocation of 24 in the control group and 28 in the experimental group (12 sessions of guided imagery relaxation through virtual reality, applied three times a week). The outcome was evaluated using the State-Trait Anxiety Inventory and statistical analysis was performed using the Generalized Linear Mixed Model. RESULTS: n the experimental group, women presented significant anxiety traits (p=0.010) before the intervention. Between the 4th and 12th week of follow-up, there was a reduction in anxiety levels, without statistical significance. CONCLUSIONS: guided imagery relaxation through virtual reality provided evidence of anxiety reduction in women with cervical cancer undergoing radiochemotherapy and may contribute to clinical practice. Brazilian Clinical Trial Registry: RBR-7ssvytb.

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ABSTRACT Objectives: to evaluate the effect of guided imagery relaxation through virtual reality on anxiety in women with cervical cancer undergoing radiochemotherapy. Methods: randomized, non-blinded, single-center clinical trial conducted at a cancer reference hospital. 52 women participated, with randomized allocation of 24 in the control group and 28 in the experimental group (12 sessions of guided imagery relaxation through virtual reality, applied three times a week). The outcome was evaluated using the State-Trait Anxiety Inventory and statistical analysis was performed using the Generalized Linear Mixed Model. Results: n the experimental group, women presented significant anxiety traits (p=0.010) before the intervention. Between the 4th and 12th week of follow-up, there was a reduction in anxiety levels, without statistical significance. Conclusions: guided imagery relaxation through virtual reality provided evidence of anxiety reduction in women with cervical cancer undergoing radiochemotherapy and may contribute to clinical practice. Brazilian Clinical Trial Registry: RBR-7ssvytb.

RESUMEN Objetivos: evaluar el efecto de la relajación con imagen guiada por realidad virtual en la ansiedad en mujeres con cáncer cervical sometidas a radioterapia. Métodos: ensayo clínico aleatorizado, no enmascarado, unicéntrico, realizado en un hospital de referencia en cáncer. Participaron 52 mujeres con asignación aleatoria, 24 en el grupo control y 28 en el experimental (12 sesiones de relajación por imagen guiada por realidad virtual, aplicadas 3 veces por semana). El resultado fue evaluado por el Inventario de Ansiedad Rasgo-Estado y el análisis estadístico fue realizado con el Generalized Linear Mixed Model. Resultados: en el grupo experimental, las mujeres presentaban rasgos de ansiedad significativos (p=0,010) antes de la intervención. Entre la 4ª y 12ª semana de seguimiento, hubo reducción en el estado de ansiedad, sin significancia estadística. Conclusiones: la técnica de relajación por imagen guiada por realidad virtual proporcionó evidencias de reducción de la ansiedad en mujeres con cáncer cervical en tratamiento con radioterapia y puede contribuir en la práctica clínica. Registro Brasileño de Ensayo Clínico: RBR-7ssvytb.

RESUMO Objetivos: avaliar o efeito do relaxamento com imagem guiada por realidade virtual na ansiedade em mulheres com câncer cervical submetidas à radioquimioterapia. Métodos: ensaio clínico randomizado, não mascarado, unicêntrico, realizado em um hospital de referência em câncer. Participaram 52 mulheres com alocação randomizada, 24 no grupo controle e 28 no experimental (12 sessões de relaxamento por imagem guiada por realidade virtual, aplicadas 3 vezes por semana). O desfecho foi avaliado pelo Inventário de Ansiedade Traço-Estado e a análise estatística foi realizada com o Generalized Linear Mixed Model. Resultados: no grupo experimental, as mulheres apresentavam traços de ansiedade significativos (p=0,010) antes da intervenção. Entre a 4ª e 12ª semana de seguimento, houve redução no estado de ansiedade, sem significância estatística. Conclusões: a técnica de relaxamento por imagem guiada por realidade virtual forneceu evidências de redução da ansiedade em mulheres com câncer cervical em tratamento com radioquimioterapia e pode contribuir na prática clínica. Registro Brasileiro de Ensaio Clínico: RBR-7ssvytb.

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Recent outbreaks of infectious diseases such as Covid-19 that have fever as one of the symptoms drive the search for systems to track people with fever quickly and non-contact, also known as sanitary barriers. The use of non-contact infrared-based instruments, especially the infrared thermal imager, has widely spread. However, the screening process has presented low performance. This article addresses the choice of regions of interest on the human face for the analysis of the individual's fever, deals with the temperature thresholds used for this analysis, as well as the way to issue the recommendation to screen the person or not. The data collection and statistical analysis of temperatures of 198 volunteers allowed us to study and define the most appropriate face regions as targets for these barriers, as well as the temperature thresholds to be used for screening for each of these regions. Besides, the paper presents a probabilistic method based on the metrological quality of the sanitary barrier to the emission of recommendation for screening potentially febrile people. The developed method was tested in feverish and non-febrile volunteers, showing complete assertiveness in the tested cases.

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Paroxysmal positional vertigo is a frequent cause for consultation. When approaching these patients, we try to differentiate central from peripheral causes, but sometimes we find manifestations that generate diagnostic doubts. In this review, we address atypical paroxysmal positional vertigo, reviewing the literature on the subject and giving a provisional definition of atypical positional vertigo as well as outlining its causes and pathophysiological mechanisms.

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BACKGROUND: Diabetes mellitus is one of the most common todays public health problems. According to a survey by the World Health Organization, this metabolic disorder has reached global epidemic proportions, with a worldwide prevalence of 8.5% in the adult population. OBJECTIVES: The present study aimed to investigate the hypoglycemic effect of aqueous extract of Mangifera indica (EAMI) leaves in streptozotocin-induced diabetic rats. METHODS: Sixty male rats were divided into 2 groups: Normoglycemic and Diabetic. Each group was subdivided into negative control, glibenclamide 3 or 10 mg/kg, EAMI 125, 250, 500, and 1000 mg/kg. Intraperitoneal injection of streptozotocin 100 mg/kg was used to DM induction. The hypoglycemic response was assessed acutely after two and four weeks of treatment. After a 6-hour fasting period, the fasting blood glucose of animals was verified, and 2.5 g/kg glucose solution was orally administered. The insulin tolerance test and plasma insulin levels assessment were performed in the morning after fasting of 12 to 14 hours. RESULTS AND CONCLUSION: The chemical analysis of EAMI showed high levels of phenolic compounds. There was no significant difference in fasting blood glucose between normoglycemic and diabetic groups, and that EAMI did not have an acute effect on diabetes. After two and four weeks of treatment, the extract significantly reduced blood glucose levels, exceeding glibenclamide effects. EAMI was effective in maintaining the long-term hypoglycemic effect, as well as, significantly increased the sensitivity of diabetic animals to insulin and the plasma insulin level.

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There is increasing evidence suggesting involvement of the renin-angiotensin system (RAS) in carbohydrate metabolism and its response to stress. Thus, the aim of the present study was to evaluate the effects of chronic inhibition of the RAS on glucose and insulin levels during acute restraint stress. Male Holtzman rats were treated with 10 mg/kg per day enalapril solution or vehicle for 14 days. After 14 days, rats were divided into three experimental groups: enalapril + restraint (ER), vehicle + restraint (VR) and enalapril + saline (ES). Rats in the restraint groups were subjected to 30 min restraint stress, whereas rats in the ES groups were given saline infusion instead. Blood samples were collected at baseline and after 5, 10, 20 and 30 min restraint stress or saline infusion. After restraint, a hyperglycaemic response was observed in the ER and VR groups that peaked at 20 and 10 min, respectively (P < 0.05 compared with baseline). The area under the glucose curve was markedly increased in the ER and VR groups compared with that in the ES group (P < 0.05 for both). Importantly, restraint induced a marked increase in insulin secretion in the ER group compared with only a mild elevation in the VR group; insulin secretion in both groups peaked at 20 min (P < 0.05 compared with baseline). Analysis of the area under the insulin curve confirmed an increase in insulin secretion in the ER compared with the VR and ES groups (P < 0.05 for both). The results of the present study reinforce that the RAS is involved in modulating responses to stress and suggest that RAS inhibition with enalapril may increase glucose-induced insulin secretion in response to acute restraint.

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Esta dissertação analisa os conteúdos das campanhas de prevenção à Aids produzidas pela emissora de televisão MTV Brasil direcionadas para o público de jovens telespectadores que compõem sua audiência. Através de uma interpretação sócio-antropológica, buscou-se analisar as representações de risco encenadas nos vídeos deste projeto de comunicação preventiva. Identifica-se uma mudança em curso quanto ao aspecto estigmatizante que caracterizava as significações da Aids na mídia, evidenciando a emergência de um discurso de socialização para o risco de contaminação pelo HIV

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Comparação entre a atual Carta Constitucional e as anteriores. Participação popular na elaboração da nova Carta. Análise histórica dos municípios. Análise das Regiões Metropolitanas (RM): criação e evolução. Fortalecimento dos municípios e, consequentemente, do federalismo. Necessidade de tornar efetiva a autonomia municipal

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