RESUMEN
Central nervous system toxicity of 5-FU could show various manifestations, such as decreased alertness, disorientation, and agitation. It is generally accepted that lesions of 5-FU encephalopathy are mainly in the deep cerebral white matter and corpus callosum on MR imaging. Here we describe a case of 5-FU encephalopathy in gastric cancer with an atypical reversible diffusion-restricted lesion on MR imaging, showing bilateral basal ganglia, thalami, and parasagittal frontal cortex involvement on diffusion and T2-weighted imaging.
Asunto(s)
Encefalopatías/inducido químicamente , Encefalopatías/patología , Encéfalo/efectos de los fármacos , Encéfalo/patología , Imagen de Difusión por Resonancia Magnética/métodos , Fluorouracilo/efectos adversos , Antimetabolitos Antineoplásicos/efectos adversos , Humanos , Inmunosupresores/efectos adversos , Masculino , Persona de Mediana EdadAsunto(s)
Ataxia/diagnóstico , Ataxia/epidemiología , Corea/diagnóstico , Corea/epidemiología , Ataxias Espinocerebelosas/diagnóstico , Ataxias Espinocerebelosas/epidemiología , Adulto , Ataxia/genética , Corea/genética , Diagnóstico Diferencial , Humanos , Corea (Geográfico)/epidemiología , Masculino , Prevalencia , Análisis de Secuencia de ADN , Ataxias Espinocerebelosas/genética , Proteína de Unión a TATA-Box/genética , Expansión de Repetición de Trinucleótido , Adulto JovenRESUMEN
Three-dimensional gyrokinetic simulations of microturbulence in magnetically confined toroidal plasmas with massively parallel computers showed that, with linear flow damping, an asymptotic residual flow develops in agreement with analytic calculations. Nonlinear global simulations of instabilities driven by temperature gradients in the ion component of the plasma support the view that turbulence-driven fluctuating zonal flows can substantially reduce turbulent transport. Finally, the outstanding differences in the flow dynamics observed in global and local simulations are found to be due to profile variations.