RESUMEN

The effect of sulfated polysaccharide fucoidan from the brown alga Laminaria japonica on morphological characteristics of mouse lymphoid organs, subpopulations of spleen mononuclear leukocytes, cytokine production and cytotoxic activity of splenocytes has been investigated. Fucoidan promoted activation and proliferation of lymphoid hematopoietic cells in primary and secondary immunogenesis bodies, increased expression of markers CD19, NK, NKT, CD25, MHC II, TCR, TLR2 and TLR4, the cytotoxic activity of splenocytes and production of immunoregulatory and proinflammatory cytokines (IL- 2, IL-12, IFN-g, TNF-a, IL-6). This suggests activation of effector mechanisms of innate immunity and adaptive immune responses via the Th-1 type.

Asunto(s)

Laminaria/química , Leucocitos Mononucleares/efectos de los fármacos , Ganglios Linfáticos/efectos de los fármacos , Extractos Vegetales/farmacología , Polisacáridos/farmacología , Bazo/efectos de los fármacos , Timo/efectos de los fármacos , Animales , Antígenos CD19/genética , Antígenos CD19/metabolismo , Médula Ósea/anatomía & histología , Médula Ósea/efectos de los fármacos , Citocinas/genética , Citocinas/metabolismo , Leucocitos Mononucleares/metabolismo , Ganglios Linfáticos/anatomía & histología , Ratones , Extractos Vegetales/química , Polisacáridos/química , Bazo/anatomía & histología , Timo/anatomía & histología , Receptores Toll-Like/genética , Receptores Toll-Like/metabolismo