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Resumen En el desarrollo histórico de la fiebre tifoidea en Chile, destaca su confusión con otras patologías infecciosas, especialmente con el tifus exantemático, problema que se resolvió mayormente con ocasión de la epidemia de 1918 de dicha enfermedad. Además se resalta la importancia del tratamiento con cloranfenicol, que significó una mejoría extraordinaria de las fiebres tifo-paratíficas, además de las acciones de salud pública y educación sanitaria, que permitieron prácticamente terminar con dichas patologías infecciosas en el país.

During the historical development of typhoid fever in Chile, its confusion with other infectious diseases is particularly noteworthy, especially with murine typhus, a problem that was mainly resolved during the 1918 epidemic. The importance of chloramphenicol treatment is also highlighted, which meant an enormous improvement in typhoid/paratyphoid fevers, in combination with public health and health education actions that allowed to almost eliminate these infectious diseases in our country.

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During the historical development of typhoid fever in Chile, its confusion with other infectious diseases is particularly noteworthy, especially with murine typhus, a problem that was mainly resolved during the 1918 epidemic. The importance of chloramphenicol treatment is also highlighted, which meant an enormous improvement in typhoid/paratyphoid fevers, in combination with public health and health education actions that allowed to almost eliminate these infectious diseases in our country.

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This article outlines the beginning of the medical studies at the Universidad de San Felipe de Santiago de Chile on the second half of the 18th century. Dr Domingo Nevin was the first professor of Prima Medicina and Proto-medico. Dr. Pedro Manuel Chaparro was the first Chilean student who complete his studies and got his degree at the same university. Both of them had remarkable achievements during the colonial Chilean Medicine.

Se reseña el comienzo de los estudios médicos en la Universidad de San Felipe, en Santiago de Chile en la segunda mitad del siglo XVIII. El Dr. Domingo Nevin fue el primer catedrático de Prima Medicina y Protomédico. Su discípulo Dr. Pedro Manuel Chaparro fue el primer alumno chileno que completó sus estudios y se graduó en la misma Universidad. Ambos personajes tuvieron destacada trayectoria en la medicina chilena colonial.

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In June 1929, the medical charity inspectors (Isauro Torres and Enrique Laval M.) submitted to the Direction of the Institution a plan for the normalization of all hospitals, which was approved by the Central Board at its meeting on 19 July of that year. The plan was to phase in the hospital action from the First-aid Posts or "Relief Houses" to the large referral hospitals. The "Relief House" would become the initial phase of hospital organization, located in rural areas. Finally, we emphasize that the Relief Houses were establishments for preventive and curative medicine in rural areas.

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This article outlines the beginning of the medical studies at the Universidad de San Felipe de Santiago de Chile on the second half of the 18th century. Dr Domingo Nevin was the first professor of Prima Medicina and Proto-medico. Dr. Pedro Manuel Chaparro was the first Chilean student who complete his studies and got his degree at the same university. Both of them had remarkable achievements during the colonial Chilean Medicine.

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In chronicles or in the historiography of the Colony in Chile there are few references about epidemics different to smallpox; like typhus, typhoid fever, dysentery, etc. Almost all, fast spreading in the country and some with high lethality, which led to overflowing the capacity of hospitals in the Chilean colonial period.

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Due to the smallpox epidemic in Santiago in 1872, a Commission or Central Board of isolation hospitals was created. These institutions were endowed with the necessary personnel to receive and assist the sick, highlighting the work of medical students, interns at these hospitals. The total number of patients treated in the infirmaries of Santiago reached 6,782, with a fatality rate of 3,073 (45.3%).

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Dr. Juan Marín Rojas, M.D., was the first Professor of History of Medicine at Universidad de Chile, navy doctor, diplomat, writer and literary critic. Member of the International Society of History of Medicine, and Correspondent Member for Chile of the "Office de Documentation de Médecine et Pharmacie Militaire", Liege, Belgium, from which his "Essay about the origin of syphilis" is transcribed with interesting historical facts and little known arguments that affirm the non-american origin of syphilis, but "aspire to leave a doubt, given not a contrary conviction".

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Grajales came to Chile in December 1807, noting that since 1805 smallpox vaccination had been introduced by Fray Pedro Manuel Chaparro, supported by the Councilor Nicholas Matorras. He founded the Vaccination Boards of Valparaiso and Santiago in 1808 and became professor of anatomy and surgery in 1819. In 1823 he received his authorization to practice medicine. He wanted to finish his medical studies at the University of San Marcos in Lima, but the war of Independence made this impossible. He returned to Spain in 1825. In 1848, he became Member of Honor of the Faculty of Medicine, Universidad de Chile.

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The Pope John XXI, named Pedro Rebuli Guiliani, was born in Lisbon, Portugal, around 1215. Known as Petrus Hispanus, Master Jullian, Peter of Spain, among other names. Besides medical studies, he studied Theology , Aristotelic Physics and Metaphysics at the University of Paris. He was named Professor of Medicine and Ophthalmology at the University of Sienna in 1247. In addition to several works about medicine, logic, and phylosophy, he authored the Tesaurus Pauperum ("Treasure of the Poor"), a prescription handbook of home-made, simple and cheap remedies. He was archbishop of Braga and Cardinal in 1272 and 1273, respectively. Elected Pope in 1276, he died tragically on May 20, 1277. Precedes this article a sketch of Medieval Medicine with emphasis on the XII and XIII centuries.

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The Pope John XXI, named Pedro Rebuli Guiliani, was born in Lisbon, Portugal, around 1215. Known as Petrus Hispanus, Master Jullian, Peter of Spain, among other names. Besides medical studies, he studied Theology , Aristotelic Physics and Metaphysics at the University of Paris. He was named Professor of Medicine and Ophthalmology at the University of Sienna in 1247. In addition to several works about medicine, logic, and phylosophy, he authored the Tesaurus Pauperum ("Treasure of the Poor"), a prescription handbook of home-made, simple and cheap remedies. He was archbishop of Braga and Cardinal in 1272 and 1273, respectively. Elected Pope in 1276, he died tragically on May 20, 1277. Precedes this article a sketch of Medieval Medicine with emphasis on the XII and XIII centuries.

El Papa Juan XXI, de nombre Pedro Rebuli Giuliani, nacido en Lisboa, Portugal, alrededor de 1215, conocido como Petrus Hispanus, Maestro Julián, Pedro de España y otros nombres; junto con los estudios médicos, realizó los de teología, física aristotélica y metafísica en la Universidad de París. Nombrado Profesor de Medicina y Oftalmología en la Universidad de Siena en 1247. Además de diversos escritos sobre medicina, lógica y filosofía, fue autor del Tesaurus Pauperum ("El Tesoro de los Pobres"), recetario con medicamentos simples y baratos, de uso casero. Fue arzobispo de Braga y Cardenal en 1272 y 1273, respectivamente. Elegido Papa en 1276, falleció trágicamente el 20 de mayo de 1277. Precede a este escrito un boceto sobre Medicina Medieval, con acento en los siglos XII y XIII.

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After the great epidemic of the exanthematic typhus of 1918-1919 in Chile, there was a gradual decrease in the number of cases , until it became endemic around 1926. Starting in 1932 and until 1939 a new epidemic outbreak occured that prompted researchers to its study supported by the new clinical and technological advances of this period. Subsequently, two important events occured: the erradication of the vector ( human louse) by means of effective insecticides and the discovery of an effective antibiotic treatment.

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The Infectious Diseases Hospital Francisco Javier Muñiz, Buenos Aires, Argentina, is the oldest in Latin America. It is over 100 years old and has a history worthy of pride. It became known as "Hospital of the pests" and was preceded by the old House of Insulation, which served as a quarantine station during epidemics of cholera, yellow fever and smallpox. The new House of Insulation, built in the neighborhood of Parque Patricios ("Barracks Hospital"), was renamed in 1904 in memory of Francisco Javier Muñiz, a former military doctor, naturalist and paleontologist. Its technical name is "Porteño Care Centre and National Reference Regional Infectious-Contagious Disease". It receives numerous national and foreign undergraduate and postgraduate students in its Departments of Infectious Diseases and Respiratory Diseases.

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The Infectious Diseases Hospital Francisco Javier Muñiz, Buenos Aires, Argentina, is the oldest in Latin America. It is over 100 years old and has a history worthy of pride. It became known as "Hospital of the pests" and was preceded by the old House of Insulation, which served as a quarantine station during epidemics of cholera, yellow fever and smallpox. The new House of Insulation, built in the neighborhood of Parque Patricios ("Barracks Hospital"), was renamed in 1904 in memory of Francisco Javier Muñiz, a former military doctor, naturalist and paleontologist. Its technical name is "Porteño Care Centre and National Reference Regional Infectious-Contagious Disease". It receives numerous national and foreign undergraduate and postgraduate students in its Departments of Infectious Diseases and Respiratory Diseases.

El Hospital de Enfermedades Infecciosas Francisco Javier Muñiz, de Buenos Aires, República Argentina, es el más antiguo de América Latina, con más de 100 años de existencia y una historia digna de orgullo; fue conocido como "Hospital de las pestes". Antecedido por la antigua Casa de Aislamiento, que sirvió de lazareto durante epidemias de cólera, fiebre amarilla y viruela. La nueva Casa de Aislamiento, construida en el barrio Parque Patricios ("Hospital de Barracas"), pasó a denominarse en 1904, Hospital Francisco Javier Muñiz, por quien fuera médico militar, naturalista y paleontólogo. Su nombre técnico es "Centro Asistencial Porteño de Referencia Nacional y Regional de Enfermedades Infecto-Contagiosas" y recibe a numerosos alumnos nacionales y extranjeros, en sus Cátedras de Enfermedades Infecciosas y de Tisio-neumología, para docencia de pre y post-grado.

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We transcribe and comment on the report about the smallpox epidemic in Valparaiso in 1865, developed by Dr. Manuel Antonio Carmona. At that time, it was considered as an important contribution to epidemiology and clinical prevention of the disease. It gave rules about the management "of smallpox at home", highlighting mechanisms of transmission of this eruptive infectious disease.

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In this communication the personality and biographical data of Dr. Francisco Julio Lafargue, second Professor of Anatomy and Physiology of the School of Medicine of the University of Chile, as well as Dr. Carlos Buston, a military surgeon are described, transcribing the episode, regarded as "literary anecdote", involving both doctors in 1843.

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Chilean historians of Medicine do not mention significant pertussis epidemics in the country during XVI, XVII and XVIII centuries, and scarce information is available about epidemics occurred during most of the XIX century, emphasizing one that happened in La Serena in 1851 and Valdivia in 1853. In the last third of the XIX century, epidemics that happened in Santiago as in other Chilean regions were described, reporting that, between 1892 and 1895, 8,181 patients died of pertussis, high numbers most likely due to the severity of epidemics observed since 1890. Measles and pertussis epidemics often co-existed, or were antedated or followed by the other.

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This article presents the history of typhoid fever in Chile since its definition as a clinical entity until our days. From this history is evident the long lasting confusion with typhus (rickettsial spotted fever) in Chile although the identity and characteristics of typhoid fever had been established in the first half of nineteenth century in Europe. This confusion could be explained because some clinical features are similar in both diseases (high fever and delirium) and because of its occurrence in poor hygienic conditions. This misconception was resolved only during 1918 on occasion of a major typhus outbreak that allowed physicians to clearly diagnose this rickettsial disease. Once typhoid fever was recognized it was possible to describe its epidemiological pattern with high endemic incidence mainly in urban districts, with summer increases and epidemic cycles. In the contemporary history of typhoid fever it is remarkable a huge outbreak during 1976-1985, associated to abrupt socioeconomical and environment crisis, as well as an abrupt diminution of the disease in 1992, with a marked reduction that persists until now. This last phenomenon was the consequence of a quasi-experimental public health intervention and sanitary education conducted in 1992 to avoid the cholera epidemic that was spreading in Perú, a neighboring country. We conclude that, although the hypothesis of environment contamination as the cornerstone in typhoid persistence was present since the recognition of the disease in 1894, it was faced efficiently only and perhaps in a definitely manner only almost 100 years later.

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