RESUMEN
Three patients with Mycobacterium simiae infection were seen during a 5-yr period. One patient with chronic infiltrative pulmonary disease had the diagnosis established by open lung biopsy. Two patients with normal chest roentgenograms had disseminated infection, one having had elective surgery for a nonfunctioning kidney. Caseating granulomata were discovered in kidney tissue sections. Both M. kansasii and M. simiae were subsequently recovered from bone marrow and urine cultures. The other patient had vertebral osteomyelitis, and M. simiae was isolated from tissue obtained by needle biopsy. To our knowledge, disseminated M. simiae infection has not been previously described.
Asunto(s)
Infecciones por Mycobacterium no Tuberculosas/diagnóstico , Infecciones por Mycobacterium/diagnóstico , Mycobacterium/aislamiento & purificación , Micobacterias no Tuberculosas/aislamiento & purificación , Anciano , Femenino , Humanos , Enfermedades Renales/etiología , Masculino , Persona de Mediana Edad , Osteomielitis/etiología , Tuberculosis Pulmonar/etiologíaRESUMEN
Four cases of chronic granulomatous skin infections (two due to Sporothrix schenckii and two to Mycobacterium marinum) were treated primarily by the intermittent application of local hyperthermia. This treatment was initiated either because of intolerance to conventional iodide therapy for sporotrichosis or as interim therapy while awaiting diagnosis of the mycobacterial infections. The response indicated that the application of heat is a useful adjunct to the therapy of these infections. Our experience, and that of others, suggests that in some cases heat alone may be curative.
Asunto(s)
Granuloma/terapia , Calor/uso terapéutico , Enfermedades Cutáneas Infecciosas/terapia , Adulto , Anciano , Enfermedad Crónica , Etambutol/uso terapéutico , Femenino , Granuloma/etiología , Humanos , Yoduros/uso terapéutico , Masculino , Persona de Mediana Edad , Infecciones por Mycobacterium no Tuberculosas , Rifampin/uso terapéutico , Enfermedades Cutáneas Infecciosas/etiología , EsporotricosisRESUMEN
The responsiveness of murine lymphocytes and human peripheral blood lymphocytes to phytohemagglutinin, concanavalin A, pokeweed mitogen, and endotoxin was tested in vitro at 32, 35, and 37 degrees C. The responses at 32 degrees C were delayed and often depressed. Mouse cells responded equally well at 35 and 37 degrees C. Human lymphocytes often responded more rapidly at 37 than at 35 degrees C. Since skin temperature, particularly that of the distal extremities, is usually 32 degrees C or less, a relative deficiency in cell-mediated immunity may exist in these sites. This may be part of the reason for the usual localization of certain infections, such as sporotrichosis, to these coller areas.
Asunto(s)
Activación de Linfocitos , Piel/inmunología , Temperatura , Animales , Células Cultivadas , Humanos , Ratones , Ratones Endogámicos , Mitógenos/farmacología , Bazo/inmunologíaRESUMEN
A patient with Legionnaires' disease developed consolidated pneumonia with severe hypoxemia and mental confusion; his condition improved with therapy with positive end-expiratory pressure, steroids, and chloramphenicol. The retrospective diagnosis was made by a fourfold rise in indirect fluorescent antibody titers. The chest x-ray films showed bilateral alveolar infiltrates and air bronchograms.
Asunto(s)
Enfermedad de los Legionarios/diagnóstico , Infecciones del Sistema Respiratorio/diagnóstico , Adulto , Animales , Técnica del Anticuerpo Fluorescente , Cobayas , Humanos , Enfermedad de los Legionarios/diagnóstico por imagen , Enfermedad de los Legionarios/terapia , Masculino , RadiografíaRESUMEN
Attempts by previous investigators have failed to show significant correlation between seasonal pollens and the birth dates of individuals as evidence for the development of tolerance in immunologically immature neonates. Using a large clinic population with adequate controls, significant correlation between ragweed, grass or tree pollen sensitivity and the dates of birth was not obtained.