RESUMEN
A patient with bleeding from the eroded distal splenic artery secondary to acute pancreatitis is presented. The pancreatic tail was found to be moderately edematous without cyst, abscess or necrosis at splenectomy. The walls of the artery showed no structural changes. The postoperative course was uneventful.
Asunto(s)
Hemorragia/etiología , Pancreatitis/complicaciones , Arteria Esplénica/patología , Enfermedad Aguda , Humanos , Masculino , Persona de Mediana Edad , Pancreatitis/patología , Pancreatitis/cirugía , EsplenectomíaAsunto(s)
Polipéptido Inhibidor Gástrico/sangre , Glucagón/sangre , Insulina/sangre , Islotes Pancreáticos/metabolismo , Trasplante de Páncreas/fisiología , Animales , Duodeno/trasplante , Prueba de Tolerancia a la Glucosa , Rechazo de Injerto , Islotes Pancreáticos/patología , Trasplante de Islotes Pancreáticos , Necrosis , Trasplante de Páncreas/patología , PorcinosRESUMEN
The effect of bilateral orchidectomy in relieving pain in 70 patients with metastatic carcinoma of the prostate was investigated by review of the case reports of a patient material from a urological department. 74% of the patients stated that the intervention was effective. Relief of pain lasting for more than seven months and attributable solely to the orchidectomy occurred in 19%. It did not prove possible to differentiate by means of biochemical or clinical parameters between the patient groups with and without beneficial effects from the intervention. 30% died during the first postoperative year. The five year survival rate was calculated to be 19%.
Asunto(s)
Orquiectomía/métodos , Cuidados Paliativos/métodos , Neoplasias de la Próstata/secundario , Anciano , Humanos , Masculino , Persona de Mediana Edad , Neoplasias de la Próstata/cirugíaRESUMEN
One hundred and seventy-six individuals with various colorectal diseases were investigated simultaneously for increased in vitro tetraploidy in dermal fibroblast cultures and for occult mandibular osteomas. In only 10 of the 176 persons were both presumed markers of colorectal genetic predisposition present in the same individual. No evidence was found that these traits are causally associated. A combination of the two presumed markers showed a tendency towards occurrence in individuals with a positive family history of colorectal cancer among first-degree relatives.
Asunto(s)
Enfermedades del Colon/genética , Neoplasias Mandibulares/genética , Osteoma/genética , Poliploidía , Enfermedades del Recto/genética , Adolescente , Adulto , Anciano , Colitis Ulcerosa/complicaciones , Colitis Ulcerosa/genética , Enfermedades del Colon/complicaciones , Neoplasias del Colon/complicaciones , Neoplasias del Colon/genética , Femenino , Humanos , Masculino , Neoplasias Mandibulares/complicaciones , Persona de Mediana Edad , Osteoma/complicaciones , Enfermedades del Recto/complicacionesRESUMEN
The diagnostic power of combined cholescintigraphy and ultrasonography was tested in 67 patients suspected of having acute cholecystitis; of these, 42 (63%) had acute cholecystitis. The predictive value of a positive scintigraphy (PVpos) was 95% and that of a negative (PVneg) was 91% (n = 67). The PVpos and PVneg of ultrasonography were 89% and 75%, respectively (n = 54), and these values did not achieve statistical significance when compared with those for scintigraphy. Inconclusive tests were 10% and 11%, respectively, but in no patient were both scintigraphy and ultrasonography inconclusive. PVpos and PVneg of combined scintigraphy and ultrasonography were 100% when the two test results were identical (n = 34). In patients with one test inconclusive or discrepancy between scintigraphy and ultrasonography, PVpos and PVneg were 79% and 67%, respectively (n = 20). The results suggest that in patients suspected of having acute cholecystitis cholescintigraphy should be the first diagnostic procedure performed. If the scintigraphy is positive, additional ultrasonographic detection of gallstones makes the diagnosis almost certain. If one diagnostic modality is inconclusive, the other makes a fair basis for diagnostic and therapeutic decision. In case of discrepancy between ultrasonography and scintigraphy the diagnosis should be reevaluated.
Asunto(s)
Colecistitis/diagnóstico , Vesícula Biliar/diagnóstico por imagen , Ultrasonografía , Enfermedad Aguda , Adulto , Anciano , Colecistitis/diagnóstico por imagen , Estudios de Evaluación como Asunto , Femenino , Humanos , Masculino , Persona de Mediana Edad , CintigrafíaRESUMEN
One hundred and seven patients (57 patients with ulcerative colitis and 50 controls) were investigated for in vitro tetraploidy (IVT) in dermal fibroblast monolayer cultures. There was no difference in incidence of IVT between patients with ulcerative colitis and controls. We advance the hypothesis that the genetic background of the colorectal cancer type found in ulcerative colitis differs from that found in the colon cancer syndromes and in non-hereditary colorectal cancers. Colorectal cancer in ulcerative colitis is probably only dependent on the degree of inflammatory lesions of the colonic mucosa.
Asunto(s)
Colitis Ulcerosa/genética , Neoplasias del Colon/genética , Poliploidía , Neoplasias del Recto/genética , Adolescente , Adulto , Anciano , Células Cultivadas , Colitis Ulcerosa/complicaciones , Neoplasias del Colon/etiología , Femenino , Humanos , Masculino , Neoplasias Mandibulares/genética , Persona de Mediana Edad , Osteoma/genética , Neoplasias del Recto/etiología , RiesgoRESUMEN
One hundred and seventy-two patients (76 patients with colorectal cancer, 46 with adenoma of the colon or rectum, and 50 controls) were investigated for in vitro tetraploidy in dermal fibroblast monolayer cultures. The incidence of increased in vitro tetraploidy (IVT) among patients with adenoma or carcinoma was significantly different from that of controls. There was no difference in the incidence of IVT between the adenoma patients and those with colorectal cancer. IVT was investigated among different subgroups of adenoma and colorectal cancer patients and was only found to be related to an inherited tendency to colorectal cancer.
Asunto(s)
Adenoma/genética , Carcinoma/genética , Neoplasias del Colon/genética , Poliploidía , Neoplasias del Recto/genética , Adulto , Anciano , Células Cultivadas , Femenino , Fibroblastos/ultraestructura , Humanos , Masculino , Metafase , Persona de Mediana EdadRESUMEN
Forty-seven patients having dysplasia in biopsies from the gastric mucosa were subjected to re-investigation. Twenty-three patients were alive at follow-up and 14 underwent gastroscopy with removal of random biopsies. The median duration of observation was 39 months, range 10-63 months. Regression of the dysplasia was found in all patients; in nine there was normal mucosa without dysplastic alterations in the control biopsies, mild dysplasia was still present in five of the patients. Our results suggest that the incidental finding of mild or moderate dysplasia does not, per se, indicate the necessity of further control, whereas severe dysplasia indicates repeat gastroscopies with biopsies, as such epithelial changes can occur together with gastric carcinoma.
Asunto(s)
Mucosa Gástrica/patología , Neoplasias Gástricas/mortalidad , Adulto , Anciano , Femenino , Estudios de Seguimiento , Gastroscopía , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Neoplasias Gástricas/patologíaRESUMEN
Orthopantomography of the mandible was carried out on 50 patients with colorectal adenoma(s) without carcinoma or any known familial disposition. Four patients (8%) had osteomas, and we advance the hypothesis that individuals with both osteomas and adenomas represent a separate type of adenoma patient. Further studies are needed to evaluate the prognostic value of the association of adenomas and mandibular osteomas.
Asunto(s)
Adenoma/diagnóstico , Neoplasias del Colon/diagnóstico , Neoplasias Mandibulares/diagnóstico por imagen , Neoplasias Primarias Múltiples/diagnóstico , Osteoma/diagnóstico por imagen , Neoplasias del Recto/diagnóstico , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Radiografía PanorámicaAsunto(s)
Neoplasias del Colon/genética , Pólipos del Colon/genética , Neoplasias Mandibulares/diagnóstico , Neoplasias Primarias Múltiples/diagnóstico , Osteoma/diagnóstico , Neoplasias del Recto/genética , Adolescente , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Primarias Múltiples/genética , RiesgoRESUMEN
In vitro tetraploidy (IVT+) in dermal fibroblast monolayer cultures has been studied in a series of patients with non-syndrome colon cancer and a control group to determine its value in identification of genetic predisposition for all colon cancers and its relevance to colon cancer occurrence on the basis of clinical history and pedigree data. Among 41 patients with colon cancer 18 (44%) had IVT+. In the control group 3 of 34 individuals (9%) showed IVT+. The difference is statistically significant (p less than 0.001). There was no correlation between a positive family cancer history, sex, age, or the presence of IVT+. Further studies using this possible in vitro biomarker may clarify the role of genetics in non-syndrome colorectal cancer.
Asunto(s)
Neoplasias del Colon/genética , Marcadores Genéticos , Poliploidía , Neoplasias del Recto/genética , Adulto , Anciano , Células Cultivadas , Cromosomas Humanos/ultraestructura , Dinamarca , Femenino , Fibroblastos/ultraestructura , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Orthopantomography of the mandible was carried out on 50 patients with colorectal cancer without known familial disposition. Twelve patients (24%) had osteomas, as against 5% in the control group (P less than 0.001). Since an increased occurrence of mandibular osteomas has earlier been demonstrated in cases of familial polyposis coli and the family cancer syndrome, we must conclude that genetic factors are presumably of more importance in the development of colorectal cancer than previously assumed.
Asunto(s)
Neoplasias del Colon/genética , Neoplasias Mandibulares/genética , Neoplasias Primarias Múltiples/genética , Osteoma/genética , Neoplasias del Recto/genética , Adulto , Anciano , Femenino , Humanos , Masculino , Neoplasias Mandibulares/diagnóstico por imagen , Persona de Mediana Edad , Oncogenes , Osteoma/diagnóstico por imagen , RadiografíaRESUMEN
Several studies report that placenta and amniotic fluid (AF) may be a source of many peptide hormones. Although the presence of gastric inhibitory polypeptide (GIP) in amniotic fluid has not been described, it is present in the fetal gut. In this study we report the presence of insulin and GIP in human AF of normal and diabetic pregnancies. GIP concentrations in the AF collected two hours after an arginine tolerance test (ATT), at 34-36 weeks of gestation, were evaluated in 8 normal and 53 diabetic pregnant women. GIP was found in all samples of AF. The mean AF-GIP concentrations were 133 +/- 19 pmol/l in controls and 111 +/- 6 pmol/l in the diabetics, being the GIP values of the diabetics belonging to White Class B significantly lower than those of normals (99 +/- 10 vs 133 +/- 19 pmol/l). The GIP/IRI molar ratio was significantly lower in the diabetics than in controls (1.2 +/- 0.2 vs 2.5 +/- 0.4); moreover the GIP/IRI molar ratio was significantly higher in AF collected from diabetic pregnant women who delivered overweight infants than in AF of normal weight infants or controls. This finding would suggest a negative feedback mechanism between GIP and insulin in fetus.
Asunto(s)
Líquido Amniótico/análisis , Polipéptido Inhibidor Gástrico/análisis , Hormonas Gastrointestinales/análisis , Embarazo en Diabéticas/metabolismo , Adulto , Peso al Nacer , Femenino , Glucosa/análisis , Humanos , Recién Nacido , Insulina/análisis , EmbarazoRESUMEN
A total of 26 patients with familial polyposis coli without extracolonic manifestations were examined by gastroduodenoscopy. Histologically verified polyps were found in 18 patients (69 percent, 95 percent confidence limits 48-86). Gastric adenoma was diagnosed in one patient, fundic gland polyposis in six patients, and duodenal adenomas in 12 patients. It is concluded that the incidence of gastroduodenal polyps is independent of the clinical presence of other extracolonic manifestations. It is advisable that polyposis patients should be followed with gastroduodenoscopy and biopsy of polyps.