RESUMEN
The paper describes a clinical and anatomical case of partial trisomy of the long arm of 17 chromosome in a baby aged 1 month and 4 days with the karyotype 46,XY, dup(17)(q21q24) from a dichorionic diamniotic twin born after in vitro fertilization. Intrahepatic bile duct hyperplasia was first detected in the patient with this chromosomal abnormality. Histological and immunohistochemical examinations of the liver were conducted using antibodies to Ki-67, CK-pan, CK8, CK 18, Vim, SMA, CD31, CD34, HER-2/neu.
Asunto(s)
Conductos Biliares Intrahepáticos , Trastornos de los Cromosomas , Conductos Biliares Intrahepáticos/patología , Trastornos de los Cromosomas/genética , Cromosomas , Femenino , Humanos , Hiperplasia/genética , Lactante , Cariotipo , TrisomíaRESUMEN
The paper describes a skin morphological examination using an immunohistochemical study (Ki-67, cytokeratin (CK) 5/6, and CK LMW) in a dead 4-month-old girl with congenital ichthyosis (Harlequin ichthyosis (HI)). There is impaired proliferative activity, abnormalities in epidermal differentiation with abnormal CK LMW synthesis, and those in the differentiation of the skin appendages. There are also pronounced sclerotic changes with a predominance of reticulin fibers, derma, and its vessels. The patient with HI and trichoepithelioma is noted to have the similar immunohistochemical phenotype of hair bulbs.
Asunto(s)
Ictiosis Lamelar/patología , Piel/patología , Resultado Fatal , Femenino , Humanos , Ictiosis Lamelar/metabolismo , Ictiosis Lamelar/terapia , Lactante , Queratinas/biosíntesisRESUMEN
Papillary microcarcinoma (PMC) of the thyroid is its papillary carcinoma (TPC), which measures 1 cm or less (WHO). According to autopsy data, the incidence of PMC that cannot be identified during a patient's life is 1 to 36%. Proliferative activity was analyzed in 75 cases of PMC, by immunohistochemical assays using antibodies to the proliferation markers Ki-67, cycline DI, and MCM2 in paraffin block slides. The proliferative activity of PMC with a size of 1-7 mm is much decreased as compared with that with a size of 8-10 mm and TPC with a larger size. The proliferative activity of PMC with a size of 8-10 mm does not differ from that of PPC of a larger size. The proliferative activity of PMC does not correlate with the presence of tumor metastases or depend on the presence of a tumor capsule, but it is significantly increased in the tumors with some high-grade component PMC more than 50% and in those with invasion.
Asunto(s)
Carcinoma Papilar/patología , Neoplasias de la Tiroides/patología , Carcinoma Papilar/metabolismo , Proliferación Celular , Femenino , Humanos , Antígeno Ki-67/metabolismo , Masculino , Persona de Mediana Edad , Neoplasias de la Tiroides/metabolismoRESUMEN
The WHO classification of thyroid tumors defines papillary microcarcinoma as papillary carcinoma, 1 cm or less in diameter. Many Russian and foreign authors include follicular and medullary types. The limiting size which permits a tumor to be considered microcarcinoma if it measures either 1 cm or 1.5 cm. A number of investigators terminologically use the data of a clinical observation of patients. In this connection, there is a great variety of terms used to define thyroid microcarcinoma. This tumor is a common random finding in the gland removed for various disease or examined at autopsy. According to autopsies, the incidence of thyroid microcarcinoma ranges from 1 to 36%. A great deal of papers and studies are dedicated to the etiology and pathogenesis of thyroid microcarcinoma and the potentialities of its early diagnosis and adequate treatment. However, little attention is given to the histological structure and proliferative activity of this tumor and their impact on prognosis and data are at times slightly contradictory or inadequately complete.