RESUMEN
The efficacy of erythromycin base (E-Mycin tablets, 333 mg) and the efficacy of tetracycline hydrochloride (Panmycin tablets) were compared in this double-blind, randomized study. Two hundred patients with moderate to moderately severe acne vulgaris were randomly assigned to the study. One hundred patients received 1 gm of erythromycin base by mouth per day for 4 weeks, followed by 333 mg/day for 8 weeks, plus placebo for tetracycline. The second group of patients received 1 gm of tetracycline by mouth per day for 4 weeks, followed by 500 mg/day for 8 weeks, plus placebo for erythromycin. Both drugs reduced acne severity to the same extent. Pustules, papules, and open comedo counts decreased significantly over the 12-week period. Seventy-seven percent of the erythromycin-treated patients and 89% of the tetracycline-treated patients stated that their acne was markedly improved or improved by week 12. Most of the side effects in patients treated with erythromycin were gastrointestinal symptoms. Among the side effects in patients treated with tetracycline were Candida vaginitis in one patient and pseudotumor cerebri in one patient.
Asunto(s)
Acné Vulgar/tratamiento farmacológico , Eritromicina/uso terapéutico , Tetraciclina/uso terapéutico , Administración Oral , Adolescente , Adulto , Ensayos Clínicos como Asunto , Diarrea/inducido químicamente , Método Doble Ciego , Eritromicina/administración & dosificación , Eritromicina/efectos adversos , Femenino , Humanos , Náusea/inducido químicamente , Embarazo , Tetraciclina/administración & dosificación , Tetraciclina/efectos adversosRESUMEN
Giant melanosomes were identified in lentigines and nevi of 4 patients from 3 kindreds with the B-K mole syndrome. They were present in some dysplastic lesions but not in malignant melanomas. In one case examined in the electron microscope, characteristic ultrastructural features were observed.
Asunto(s)
Tumores de Células Gigantes/patología , Nevo/patología , Neoplasias Cutáneas/patología , Adulto , Femenino , Tumores de Células Gigantes/ultraestructura , Humanos , Masculino , Microscopía Electrónica , Persona de Mediana Edad , Nevo/genética , Nevo/ultraestructura , Neoplasias Cutáneas/genética , Neoplasias Cutáneas/ultraestructuraRESUMEN
Many clinical abnormalities in atopic eczema have been attributed to an imbalance in autonomic nervous system control, specifically a partial blockade of beta-adrenergic responsiveness. The lysosomal enzyme beta-glucuronidase is released from granulocytes during in vitro incubation with complement-activated zymosan particles. Isoproterenol will inhibit the release of this lysosomal enzyme from the granulocyte and the isoproterenol effect is associated with increased granulocyte cyclic AMP formation. In atopic eczema and asthma, this granulocyte response to isoproterenol is impaired. Histamine also inhibits in vitro zymosan induced release of beta-glucuronidase and this is an H2 histamine effect. In asthma, this H2 histamine response is diminished. In the following study, we found a similar impairment in histamine inhibition of beta-glucuronidase release and formation of granulocyte cAMP in atopic eczema. This defect was found only in granulocytes from patients with active eczema. Thus in active atopic eczema, defects in the pharmacological response of the granulocyte are not limited to beta-adrenergic agonists but include H2 histamine activity.
Asunto(s)
Eccema/sangre , Granulocitos/metabolismo , Receptores Histamínicos H2/metabolismo , Receptores Histamínicos/metabolismo , Adulto , AMP Cíclico/sangre , Femenino , Glucuronidasa/sangre , Granulocitos/efectos de los fármacos , Granulocitos/enzimología , Histamina/farmacología , Humanos , Técnicas In Vitro , Lisosomas/efectos de los fármacos , Lisosomas/enzimología , Masculino , Metiamida/farmacología , Persona de Mediana Edad , Zimosan/farmacologíaRESUMEN
Woolly hair is very curly hair that is characteristically unruly and will not form naturally into locks. Woolly hair nevus first appears when the scalp hair begins to grow. It is seen as a patch of unruly, very curly hair, arising in a field of otherwise unremarkable scalp hair. Woolly hair can also be seen as a hereditary trait involving the entire scalp and in acquired forms. It may be distinguished from two other types of unruly hair, pili torti and spun glass hair.
Asunto(s)
Cabello/anomalías , Nevo Pigmentado/complicaciones , Neoplasias Cutáneas/complicaciones , Adulto , Dermatitis Seborreica/complicaciones , Femenino , Humanos , Masculino , Dermatosis del Cuero Cabelludo/complicaciones , Verrugas/complicacionesRESUMEN
A new method of sectioning hair specimens has been devised that employs Araldite as an embedding medium. This has greater rigidity than paraffin and eliminates the possibility of compression on sectioning with resultant distortion of the hair shaft. Semithin sections could be sectioned at the perpendicular and examined with phase contrast optics. By correlating the cross section with the longitudinal position of the hair shaft within this translucent medium, exact cross sections of various hair types could be obtained.